Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis

Table 1 Characteristics of patients with cirrhosis

	Wilson disease-associated cirrhosis (n = 60)	Hepatitis B-associated cirrhosis (n = 56)	P value
Age (yr)	22.00 (16.25-29.75)	52.00 (45.25-62.00)	< 0.001
Male gender	27 (45.00)	46 (82.14)	< 0.001
Disease duration (years)	3.00 (1.13-7.00)	17.50 (3.25-38.25)	< 0.001
Diabetes	1 (1.67)	11 (19.64)	0.001
Hypertension	0 (0)	13 (23.21)	< 0.001
Alcohol drinking	0 (0)	12 (21.42)	< 0.001
Smoking	2 (3.33)	13 (23.21)	0.001
TC (mmol/L)	4.22 (3.67-4.67) (n = 39)	4.10 (2.71-4.67) (n = 39)	0.327
TG (mmol/L)	0.94 (0.70-1.37) (n = 39)	0.99 (0.65-1.60) (n = 39)	0.853
HDL (mmol/L)	1.40 ± 0.30 (n = 39)	1.16 ± 0.32 (n = 39)	0.786
LDL (mmol/L)	2.17 ± 0.61 (n = 39)	2.28 ± 0.91 (n = 39)	0.014

Data are presented as medians (interquartile ranges) or n (%). HDL: High-density lipoprotein; LDL: Low-density lipoprotein; TC: Total cholesterol; TG: Triacylglycerol.

Table 2 Relationship between cirrhotic etiology and liver fibrosis markers

	Wilson disease-associated cirrhosis (n = 60)	Hepatitis B-associated cirrhosis (n = 53)	P value
Type IV collagen (ng/mL)	61.55 (52.18-72.11)	79.48 (63.16-107.56)	< 0.001
PIIINP (μg/mL)	79.92(54.68-122.65)	109.16 (70.24-155.30)	0.019
Laminin (ng/mL)	104.09 (92.80-118.21)	96.27 (70.08-116.02)	0.013
Hyaluronic acid (ng/mL)	75.12 (39.27-131.98)	193.16 (74.77-625.90)	< 0.001

Data are presented as medians (interquartile ranges). PIIINP: Procollagen type III N-terminal propeptide.

Table 3 Relationship between cirrhotic etiology and liver function indices

	Wilson disease-associated cirrhosis (n = 60)	Hepatitis B-associated cirrhosis (n = 56)	P value
ALT (U/L)	23.00 (17.00-34.75)	33.50 (19.33-81.25)	0.002
AST (U/L)	25.00 (19.00-40.00)	41.50 (27.25-96.50)	< 0.001
Albumin (g/L)	40.00 (37.00-43.00)	33.00 (29.25-39.75)	< 0.001
PT (s)	14.05 (13.43-14.78)	15.50 (13.93-18.18)	0.003
Bilirubin (μmol/L)	12.40 (8.55-18.38)	21.70 (12.73-41.08)	< 0.001
Hepatic encephalopathy	0 (0)	3 (5.36)	0.109
Child-Pugh classification			< 0.001
A	54 (90.00)	24 (42.86)
B	4 (6.67)	24 (42.86)
C	2 (3.33)	8 (14.29)

Data are presented as medians (interquartile ranges) or N (%). ALT: Alanine transferase; AST: Aspartate transaminase; PT: Prothrombin time.

Table 4 Logistic regression analysis of Child-Pugh classification in patients with Wilson disease-associated cirrhosis vs patients with hepatitis B-associated cirrhosis

	OR	95%CI	P value
Child-Pugh classification
A	Ref.	-	-
B	0.046	0.006-0.387	0.005
C	0.164	0.013-2.063	0.162

Data were adjusted for age, gender, disease duration, diabetes, hypertension, alcohol drinking, and smoking. CI: Confidence interval; OR: Odds ratio; Ref: Reference.

Table 5 Relationship between cirrhotic etiology and features of portal hypertension

	Wilson disease-associated cirrhosis (n = 60)	Hepatitis B-associated cirrhosis (n = 56)	P value
Portal vein diameter (mm)	10.00 (8.00-10.00)	14.00 (12.00-16.00)	< 0.001
Ascites	2 (3.33)	24 (42.86)	< 0.001
Splenomegaly/splenectomy	53 (88.33)	42 (75.00)	0.062

Data are presented as medians (interquartile ranges) or n (%).

Table 6 Logistic regression analysis of risk of hematocytopenia due to splenomegaly

	OR	95%CI	P value
Leucopenia	4.41	1.29-15.12	0.018
Erythropenia	-	-	-
Thrombocytopenia	23.08	2.86-186.11	0.003

Data were adjusted for age, gender, disease duration, diabetes, hypertension, alcohol drinking, smoking, and Child-Pugh classification. CI: Confidence interval; OR: Odds ratio.