Surgical techniques and postoperative management to prevent postoperative pancreatic fistula after pancreatic surgery

Table 1 Characteristics and intraoperative data of 7 randomized controlled trials included studies comparing pancreatogastrostomy vs pancreatojejunostomy

				Sample	Pancreatic parenchyma (soft/hard)		Technique
First author	Country	Pubrication year	Setting	n (PG/PJ)	PG group	PJ group	PG group	PJ group
Fernandez-Cruz et al[30]	Spain	2008	Single center	108 (53/55)	24/29	25/30	Double layer with stent	Double layer with stent
Wellner et al[31]	Germany	2012	Single center	116 (59/57)	36/23	29/28	Invagination	Double layer with stent
Topal et al[32]	Belgium	2013	Multiple canters	329 (162/167)	N/A	N/A	Double or single layer	Double or single layer
Figueras et al[33]	Spain	2013	Multiple canters	123 (65/58)	34/31	33/58	Double or single layer	Double layer with stent
El Nakeeb et al[34]	Egypt	2014	Single center	90 (45/45)	26/19	22/23	Double layer	Double layer without stent
Grendar et al[35]	Canada	2015	Single center	98 (48/50)	25/23	18/32	Double layer	Double layer with or without stent
Keck et al[5]	Germany	2016	Multiple canters	320 (171/149)	95/66	83/62	Invagination	Duct-to-mucosa

PG: Pancreatogastrostomy; PJ: Pancreatojejunostomy; N/A: Not applicable.

Table 2 Characteristics and intraoperative data of 7 randomized controlled trials included studies comparing invagination vs duct-to-mucosa

		Pubricat-ion	Sample		Pancreatic parenchyma (soft/ hard)		stents		Use of smatostatin analogs
First author	Country	year	D to M	Inv	D to M	Inv	D to M	Inv	D to M	Inv	Result
Peng et al[56]	China	2007	111	106	39/72	37/69	NA	No	No	No	Invagina-tion significan-tly reduced POPF
Berger et al[57]	United States	2008	97	100	50/47	51/49	Intraoper-ative temporary	No	No	No	Invaginat-ion significan-tly reduced POPF
Senda et al[58]	Japan	2018	61	59	31/30	30/29	Yes	Yes	NA	NA	NS
Bai et al[59]	China	2016	64	68	36/28	44/24	47 used	52 used	2 used	12 used	D to M significan-tly reduced POPF
El Nakeeb et al[60]	Egypt	2018	53	54	25/28	27/27	Intraoper-ative temporary	Intraoper-ative temporary	NA	NA	NS
Singh et al[61]	India	2017	97	96	42/55	48/48	15 used	26 used	38 used	31 used	NS
Maggiori et al[62]	France	2010	25	22	11/14	10/12	NA	NA	11 used	10 used	NS

D to M: Duct to mucosa; Inv: Invagination; NA: Not available; NS: Not significant.