Immunotherapy with dendritic cells and cytokine-induced killer cells for hepatocellular carcinoma: A meta-analysis

doi:10.3748/wjg.v25.i27.3649

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World Journal of Gastroenterology

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1007-9327

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Meta-Analysis

World J Gastroenterol. Jul 21, 2019; 25(27): 3649-3663
Published online Jul 21, 2019. doi: 10.3748/wjg.v25.i27.3649

Table 1 Clinical information and characteristics of included studies

Author (year)	Country	Control	Immuno-therapy interven-tions	Patients		Child-Pugh score A/B/C		Immune cell regimens	Course
Author (year)	Country	Control	Immuno-therapy interven-tions	Control	Trial	Control	Trial	Immune cell regimens	Course
Nakamoto (2007)[19]	Japan	TACE	TACE + DC	11	10	4/7/0	8/2/0	5 × 10⁶	1
Nakamoto (2011)[20]	Japan	TACE	TACE + DC	22	13	NR	5/8/0	5 × 10⁶	1
El Ansary (2013)[21]	Egypt	Supportive treatment	DC	15	15	0/14/1	0/15/0	20 × 10⁶	1
Sun (2015)[22]	China	Resection + FOLFOX6	Resection + DC	80	80	NR	NR	8.9 × 10⁹	6
Lee (2017)[23]	South Korea	Resection/RFA/PEI	Resection/RFA/PEI + DC	75	69	NR	NR	3 × 10⁷	6
Weng (2007)[24]	China	TACE + RFA	TACE + RFA + CIK	40	45	33/7/0	36/9/0	1.0-1.5 × 10¹⁰	8/9
Dong (2008)[25]	China	Resection	Resection + CIK	43	84	34/9/0	68/16/0	1.0-2.0 × 10¹⁰	3/5
Hao (2010)[26]	China	TACE	TACE + RFA + CIK	74	72	66/8/0	65/7/0	1.0-5.0 × 10¹⁰	4
Pan (2010)[27]	China	TACE + RFA	TACE + RFA + CIK	39	42	NR	NR	1.0 × 10¹⁰	4
Pan (2013)[28]	China	Resection	Resection + CIK	206	204	206/0/0	204/0/0	1.0-1.5 × 10¹⁰	4
Lee (2015)[29]	South Korea	Resection/RFA/PEI	Resection/RFA/PEI + CIK	112	114	112/0/0	114/0/0	NR	16
Pan (2015)[30]	China	Resection	Resection + CIK	520	511	NR	NR	1.0-1.5 × 10¹⁰	4
Chen (2016)[31]	China	Resection	Resection + CIK	118	231	205/12/0	222/9/0	1.0-1.5 × 10¹⁰	4
Li (2016)[32]	China	Oxaliplatin + Capecitabine	CIK	37	37	33(A + B)/4(C)	27(A + B)/10(C)	NR	NR
Chang (2018)[33]	China	Resection	Resection + CIK	145	145	145/0/0	145/0/0	NR	NR
Lee (2018)[34]	South Korea	Resection/RFA/PEI	Resection/RFA/PEI + CIK	112	114	112/0/0	114/0/0	6.4 × 10⁹	16
Cui (2014)[35]	China	RFA	RFA + NK/γδT/CIK	32	30	14/18/0	18/12/0	1.2-2.0 × 10⁹	8
Qian (2016)[36]	China	RFA	RFA + NK/γδT/CIK	31	73	NR	NR	1.0-2.0 × 10⁹	8
Qiu (2011)[37]	China	Resection	Resection + DC/CIK	9	9	NR	NR	2.0-20.0 × 10⁹	NR
Niu (2013)[38]	China	Cryoablation	Cytotherapy + DC/CIK	12	21	NR	NR	6.0-10.0 × 10⁹	NR
Shimizu (2014)[39]	Japan	Resection	Resection + DC/CIK	40	35	44/8/0	34/8/0	NR	NR
Yu (2015)[40]	China	Microwave ablation	Microwave ablation + DC/CIK	15	14	15/0/0	13/1/0	NR	NR

TACE: Transcatheter arterial chemoembolization; RFA: Radiofrequency ablation; PEI: Percutaneous ethanol injection; DC: Dendritic cell; CIK: Cytokine-induced killer cell; NK: Nature killer cell; NR: Not reported.

Table 2 Quality assessment of randomized controlled trials with Cochrane Collaboration’s tool

Author (year)	Selection	Performance	Detection	Attrition	Reporting	Other
Author (year)	Bias	Bias	Bias	Bias	Bias	Bias
El Ansary (2013)	Unclear	High	Unclear	Low	Low	Low
Sun (2015)	Unclear	High	Unclear	Low	Low	Low
Dong (2008)	Unclear	High	Unclear	Low	Low	Low
Lee (2015)	Unclear	High	Unclear	Low	Low	Low
Lee (2018)	Unclear	High	Unclear	Low	Low	Low
Qiu (2011)	Unclear	High	Unclear	Low	Low	Low
Yu (2015)	Unclear	High	Unclear	Low	Low	Low

Table 3 Quality assessment of non-randomized controlled trials with MINORS

Author (year)	1	2	3	4	5	6	7	8	9	10	11	12
Nakamoto (2007)	2	2	2	0	0	1	2	0	2	2	2	2
Nakamoto (2011)	2	2	2	2	0	1	2	0	2	2	2	2
Lee (2017)	2	2	2	2	0	2	0	2	2	2	2	2
Weng (2007)	2	2	2	2	0	2	2	0	2	2	2	2
Hao (2010)	2	2	2	2	0	2	2	2	2	2	2	2
Pan (2010)	2	2	2	2	0	1	2	0	2	2	2	2
Pan (2013)	2	2	2	2	0	1	2	0	2	2	2	2
Pan (2015)	2	2	2	2	0	2	2	0	2	2	2	2
Chen (2016)	2	2	2	2	0	2	2	0	2	2	2	2
Li (2016)	2	2	2	2	0	1	2	2	2	2	2	2
Chang (2018)	2	2	2	2	0	2	2	2	2	2	2	2
Cui (2014)	2	2	2	0	0	1	2	0	2	2	2	2
Qian (2016)	2	2	2	1	0	2	0	0	2	2	2	2
Niu (2013)	2	2	2	0	0	2	2	0	2	2	2	2
Shimizu (2014)	2	2	2	0	0	2	2	2	2	2	2	2

Citation: Cao J, Kong FH, Liu X, Wang XB. Immunotherapy with dendritic cells and cytokine-induced killer cells for hepatocellular carcinoma: A meta-analysis. World J Gastroenterol 2019; 25(27): 3649-3663
URL: https://www.wjgnet.com/1007-9327/full/v25/i27/3649.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i27.3649