Copyright ©The Author(s) 2019.
World J Gastroenterol. Jun 21, 2019; 25(23): 2863-2877
Published online Jun 21, 2019. doi: 10.3748/wjg.v25.i23.2863
Table 1 MicroRNAs regulate inflammation and occurrence of colorectal cancer
MicroRNAsTarget genesFunctions in CRC
MiR-105, miR-19a,NF-κBPromoted CRC progression
MiR-21, miR-181b-1, miR-572STAT3Promoted CRC progression
MiR-21, miR-200b, miR-1246TGF-βPromoted proliferation
MiR-34aIL-6R/PAI1Promoted CRC progression
MiR-24IFN-γ/TNF-αInhibited the cytotoxic effect of NK cells
MiR-34aTGF-β/Smad4Inhibited autophagy
MiR-196b-5pSTAT3Promoted chemical resistance
MiR-148a, miR-6869-5p, miR-139-5pNF-κBInhibited CRC occurrence
MiR-1299, miR-149, miR-214STAT3Inhibited tumor formation
MiR-329TGF-β1Inhibited CRC occurrence
Table 2 LncRNAs regulate the inflammation-cancer transformation
LncRNATarget genesFunctions in CRC
PRINSmiR-491-5p/PMAIP1/TFF3Inhibited apoptosis
FEZF1-AS1PKM2/STAT3Accelerated CRC occurrence
AB073614JAK/STAT3Induced EMT
HOTAIRMiR-218/EZH2/NF-kBChemotherapeutic resistance