Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease

doi:10.3748/wjg.v24.i8.941

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Feb 28, 2018 (publication date) through Aug 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Trials Study

World J Gastroenterol. Feb 28, 2018; 24(8): 941-948
Published online Feb 28, 2018. doi: 10.3748/wjg.v24.i8.941

Table 1 Characteristics of patients

	UC	CD	UIBD	Total
No. of patients (n)	39 (17.8)	176 (80.4)	4 (1.8)	219
Age in yr	42.74 ± 13.60	30.51 ± 11.84	45.25 ± 16.62	33.44 ± 13.08
Sex, M/F	27/12	132/44	1/3	161/59
TPMT genotype
A/A	38 (97.4)	174 (98.9)	4 (100)	216 (98.6)
A/G^a	1 (2.6)	2 (1.1)	0	3 (1.4)
NUDT15 genotype
C/C	31 (79.5)	140 (79.5)	4 (100)	175 (79.9)
C/T	8 (20.5)	36 (20.5)	0	44 (20.1)
AZA therapy	3 (7.7)	77 (43.8)	0	80 (36.5)

Data are presented as n (%) or mean ± SD.

^aP < 0.05 vs NUDT15 C/T. CD: Crohn’s disease; UC: Ulcerative colitis; UIBD: Undetermined inflammatory bowel disease, AZA: Azathioprine.

Table 2 Association analysis of azathioprine and NUDT15 polymorphism

Genotype of *NUDT15*	C/C	C/T	Total	P value
No. of patients (gene frequencies)	64 (90.0)	16 (10.0)	80	-
Age in yr	33.69 ± 11.31	31.13 ± 12.40	33.18 ± 11.50	0.429
Sex, M/F	48/16	11/5	59/21	0.611
Disease stages
Remission	6 (9.4)	3 (18.8)	9 (11.3)	0.253
Mild activity	10 (15.6)	2 (12.5)	12 (15.0)
Moderate activity	35 (54.7)	5 (31.3)	40 (50.0)
Severe activity	13 (20.3)	6 (37.5)	19 (23.8)
Initial dosage of AZA in mg/kg daily	1.044 ± 0.318	1.241 ± 0.252	1.082 ± 0.441	0.596
Duration of AZA in mo	8.1 ± 11.19	9.3 ± 9.95	8.4 ± 10.90	0.686
Combined with corticosteroids	28 (43.8)	5 (31.3)	33 (41.3)	0.071
Combined with IFX	14 (21.9)	7 (43.8)	21 (26.3)
Combined with IFX and corticosteroid	0	1 (6.3)	1 (1.3)
Leukopenia	11 (17.2)	8 (50.0)^a	19 (23.8)	0.006

Data are presented as n (%) or mean ± SD.

^aP < 0.05 vs NUDT15 C/C developed leukopenia. AZA: Azathioprine; IFX: Infliximab.

Table 3 Multivariate association analyses of azathioprine-induced leukopenia

Factor	P value	OR (95%CI)	RR	EF/PF
Age	0.714	-	-	-
Sex, female	0.039	0.146 (0.023-0.909)	0.527	0.124
Disease stages	0.509	-		-
Duration of AZA	0.438	-		-
Combined with corticosteroids	0.023	0.201 (0.050-0.798)	0.437	0.253
Combined with IFX	0.339	-	-	-
Combined with IFX and corticosteroid	1.000	-	-	-
TPMT	1.000	-	-	-
NUDT15	0.004	7.663 (1.893-31.023)	2.909	0.276

Citation: Wang HH, He Y, Wang HX, Liao CL, Peng Y, Tao LJ, Zhang W, Yang HX. Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease. World J Gastroenterol 2018; 24(8): 941-948
URL: https://www.wjgnet.com/1007-9327/full/v24/i8/941.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i8.941