Prognostic value of sorting nexin 10 weak expression in stomach adenocarcinoma revealed by weighted gene co-expression network analysis

Table 1 Patient characteristics and univariate analysis, n = 362

Characteristic	n (%)	DFS			OS
		Time (mo)	P value	F value	Time (mo)	P value	F value
Age (median, yr)			0.138	2.209		0.373	0.795
≥ 60	192 (53.0)	37.25			44.18
< 60	170 (47.0)	41.26			46.29
Gender			0.194	1.695		0.463	0.540
Male	248 (68.5)	37.94			44.58
Female	114 (31.5)	41.72			46.46
Bormann type			0.000	27.349		0.000	23.230
I	28 (7.7)	64.04			64.04
II	161 (44.5)	45.96			51.32
III	167 (46.1)	22.80			36.72
IV	6 (1.7)	16.03			27.33
Tumor size			0.000	31.865		0.000	25.094
≥ 5 cm	153 (42.3)	30.59			38.46
< 5 cm	209 (57.7)	45.38			50.09
Location			0.212	1.558		0.403	0.912
Up	76 (21.0)	34.55			42.11
Middle	102 (28.2)	40.75			46.36
Low	184 (50.8)	40.13			45.78
Lauren type			0.241	1.428		0.214	1.549
Intestinal	166 (45.9)	41.87			47.77
Mixed carcinoma	84 (23.2)	39.07			44.99
Diffuse	112 (30.9)	35.62			42.07
Tumor differentiation			0.000	17.711		0.000	15.214
Moderate and high	176 (48.6)	44.84			49.83
Poor	186 (51.4)	33.74			40.76
Vessel invasion			0.000	21.849		0.000	20.983
Yes	107 (29.6)	29.67			37.02
No	255 (70.4)	43.10			48.59
Perineural invasion			0.000	17.726		0.000	15.346
Yes	88 (24.3)	28.14			36.38
No	274 (75.7)	42.66			48.00
T category			0.000	70.121		0.000	49.574
T1	68 (18.8)	65.72			65.75
T2	24 (6.6)	60.25			62.00
T3	12 (3.3)	59.04			61.33
T4	258 (71.3)	29.29			37.46
N category			0.000	248.092		0.000	223.946
N0	152 (42.0)	61.93			63.47
N1	62 (17.1)	36.73			48.52
N2	68 (18.8)	24.07			33.05
N3	80 (22.1)	10.49			17.52
TNM stage			0.000	386.623		0.000	231.577
I	77 (21.3)	64.47			65.69
II	87 (24.0)	62.99			64.49
III	194 (53.6)	19.07			29.04
IV	4 (1.1)	5.50			9.50
SNX10			0.000	21.849		0.000	18.278
Over- expression	172 (47.5)	44.97			49.95
Weak-expression	190 (52.5)	33.85			40.84

DFS: Disease-free survival; OS: Overall survival; SNX10: Sorting nexin 10.

Table 2 Sorting nexin 10 expression and clinicopathologic characteristics, n (%)

Characteristic	SNX10
	High	Low	P value	χ2 value
	172 (47.5)	190 (52.5)
Age (median, yr)			0.599	0.342
≥ 60	94 (49.0)	98 (51.0)
< 60	78 (45.9)	92 (54.1)
Gender			0.385	0.755
Male	114 (46.0)	134 (54.0)
Female	58 (50.9)	56 (49.1)
Tumor size			0.566	0.330
≥ 5 cm	70 (45.8)	83 (54.2)
< 5 cm	102 (48.8)	107 (51.2)
Location			0.490	1.426
Up	33 (43.4)	43 (56.6)
Middle	46 (45.1)	56 (54.9)
Low	93 (50.5)	91 (49.5)
Bormann type			0.167	5.071
I	13 (46.4)	15 (53.6)
II	85 (52.8)	76 (47.2)
III	73 (43.7)	94 (56.3)
IV	1 (16.7)	5 (83.3)
Lauren type			0.172	3.521
Intestinal	76 (45.8)	90 (54.2)
Mixed carcinoma	35 (41.7)	49 (58.3)
Diffuse	61 (54.5)	51 (45.5)
Tumor differentiation			0.000	251.93
Moderate and high	159 (90.3)	17 (9.7)
Poor	13 (7.0)	173 (93.0)
Vessel invasion			0.264	1.246
Yes	46 (43.0)	61 (57.0)
No	126 (49.4)	129 (50.6)
Perineural invasion			0.657	0.198
Yes	40 (45.5)	48 (54.5)
No	132 (48.2)	142 (51.8)
T category			0.042	8.708
T1	40 (58.8)	28 (41.2)
T2	11 (45.8)	13 (54.2)
T3	8 (66.7)	4 (33.3)
T4	113 (43.8)	145 (56.2)
N category			0.000	18.778
N0	92 (60.5)	60 (39.5)
N1	25 (40.3)	37 (59.7)
N2	28 (41.2)	40 (58.8)
N3	27 (33.8)	53 (66.3)
TNM stage			0.001	16.744
I	44 (57.1)	33 (42.9)
II	53 (60.9)	34 (39.1)
III	73 (37.6)	121 (62.4)
IV	2 (50.0)	2 (50.0)

SNX10: Sorting nexin 10.

Table 3 Multivariate analysis of significant prognostic factors for survival in stomach adenocarcinoma patients

Variable	DFS			OS
	P value	HR	95%CI	P value	HR	95%CI
Bormann	0.418	1.109	0.864-1.424	0.531	1.083	0.844-1.388
Tumor size	0.395	0.884	0.665-1.175	0.625	0.931	0.701-1.238
Tumor differentiation	0.686	0.874	0.455-1.678	0.658	0.859	0.440-1.679
Vessel invasion	0.292	1.424	0.738-2.746	0.419	1.320	0.674-2.586
Perineural invasion	0.171	0.815	0.607-1.093	0.269	0.864	0.628-1.139
TNM stage	0.000	78.873	36.367-171.057	0.000	76.703	35.600-165.262
SNX10 expression	0.014	0.698	0.524-0.930	0.017	0.704	0.528-0.940

DFS: Disease-free survival; OS: Overall survival; SNX10: Sorting nexin 10; HR: Hazard ratio; CI: Confidence interval.