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©The Author(s) 2018.
World J Gastroenterol. Oct 21, 2018; 24(39): 4472-4481
Published online Oct 21, 2018. doi: 10.3748/wjg.v24.i39.4472
Published online Oct 21, 2018. doi: 10.3748/wjg.v24.i39.4472
Table 1 Demographic, endoscopic and histologic characteristics of the study population
Patient data | All sample (n = 386) | HGD (n = 12) | Non-HGD (n = 367) |
Age at study inclusion | 60.0 (13.1) [61.1, 18.4-89.6] | 66.3 (12.8) [66.6, 42.4-85.8] | 59.8 (13.2) [60.6, 18.4-89.6] |
Gender - male | 268 (69.43) | 9 (75) | 253 (68.94) |
Number of endoscopies per patient | 2.5 (2.0) [2, 1-17] | 6.6 (2.6) [7, 3-11] | 2.4 (1.7) [2, 1-10]b |
Patients with multiple endoscopies | 245 (63.47%) | 12 (100) | 227 (61.9)a |
Circumferential extent of BE (cm) | 3.3 (3.3) [2, 0-19] | 4.5 (2.92) [4.5, 1-11] | 3.2 (3.23) [2, 0-19] |
Maximal extent of BE (cm) | 4.4 (3.2) [3, 0.2-20] | 6.0 (3.22) [6, 2-14] | 4.25 (3.17) [3, 0.2-20]a |
Presence of endoscopic abnormalities | 56 (14.51) | 8 (66.67) | 44 (11.99)b |
Ultra-short BE segment (BE < 1 cm) | 28 (7.43) | 0 (0) | 28 (7.8) |
Short BE segment (1 cm ≤ BE < 3 cm) | 124 (32.89) | 2 (18.18) | 122 (33.98) |
Long BE segment (BE ≥ 3 cm) | 225 (59.68) | 9 (81.82) | 209 (58.22) |
Worst degree of dysplasia | |||
Esophageal adenocarcinoma | 6 (1.6) | ||
Intramucosal carcinoma | 1 (0.3) | ||
High grade dysplasia | 12 (3.1) | ||
Low grade dysplasia | 19 (4.9) |
Table 2 Overall cancer cases, stratified to pre-study and incident cases n (%)
Pre-study cancers | Incident cancers | Lifetime cancers | |
Esophagus | 2 (0.5)2 | 4 (1) | 6 (1.6) |
Cardia | 2 (0.5) | 3 (0.8) | 5 (1.3) |
Stomach | 3 (0.8) | 0 (0) | 3 (0.8) |
Colorectal cancer | 9 (2.3) | 1 (0.3) | 10 (2.6) |
Small intestine | 1 (0.3) | 0 (0) | 1 (0.3) |
Cholangiocarcinoma | 1 (0.3) | 0 (0) | 1 (0.3) |
Pancreas | 0 (0) | 2 (0.5) | 2 (0.5) |
Bladder | 5 (1.3) | 4 (1) | 9 (2.3) |
Prostate | 11 (2.8) | 0 (0) | 11 (2.8) |
Kidney | 2 (0.5) | 2 (0.5) | 4 (1) |
Hematologic cancer | 8 (2.07) | 4 (1) | 12 (3.1) |
Skin | 4 (1) | 2 (0.5) | 6 (1.6) |
Breast | 4 (1) | 2 (0.5) | 6 (1.6) |
Thyroid | 3 (0.8) | 0 (0) | 3 (0.8) |
Lung | 0 (0) | 2 (0.5) | 2 (0.5) |
Kaposi | 0 (0) | 1 (0.3) | 1 (0.3) |
Laryngeal | 3 (0.8) | 0 (0) | 3 (0.8) |
Cervical | 1 (0.3) | 0 (0) | 1 (0.3) |
Any type of cancer | 59 (15.3) | 27 (7) | 86 in 75 (19.4) patients1 |
BE cancer | 3 (0.8) | 7 (1.8) | 10 in 10 (2.6) patients |
Non-BE cancers | 56 (14.5) | 20 (5.2) | 76 in 65 (16.8) patients |
Table 3 Univariate and multivariable Cox regression for the prediction of non- Barrett’s esophagus cancers
n = 379 (excluding EAC and IMC) | HR (95%CI) | Adjusted HR (95%CI) |
Age at study inclusion1 | 1.11 (0.99-1.24) | 1.07 (0.95-1.21) |
Gender - male | 2.19 (0.63-7.55) | |
Number of endoscopies per patient | 0.82 (0.59-1.12) | 0.72 (0.50-1.03) |
Presence of endoscopic abnormalities | 1.19 (0.34-4.09) | |
Circumferential extent of BE (cm) | 0.99 (0.79-1.26) | |
Maximal extent of BE (cm) | 1.06 (0.92-1.23) | |
Ultra-short segment (BE < 1 cm) | 1 | |
Short segment (1 cm ≤ BE < 3 cm) | 0.96 (0.11-8.24) | |
Long segment (BE ≥ 3 cm) | 0.99 (0.13-7.85) | |
Pre-study cancer history | 2.58 (0.92-7.25) | 2.12 (0.73-6.17) |
HGD vs non-HGD | 3.40 (0.78-14.84) | 8.32 (1.35-51.33)a |
Table 4 Univariate and multivariable Cox regression for the prediction of any cancer
n = 386 (including EAC and IMC) | HR (95%CI) | Adjusted HR (95%CI) |
Age at study inclusion1 | 1.09 (0.99-1.20) | 1.08 (0.97-1.21) |
Gender - male | 2.29 (0.79-6.67) | |
Number of endoscopies per patient | 1.11 (0.96-1.29) | 0.99 (0.82-1.21) |
Presence of endoscopic abnormalities | 2.27 (0.95-5.44) | |
Circumferential extent of BE (cm) | 1.10 (0.96-1.26) | |
Maximal extent of BE (cm) | 1.12 (1.008-1.24)a | 1.13 (1.000-1.27) |
Ultra-short segment (BE < 1cm) | 1 | |
Short segment (1 cm ≤ BE < 3 cm) | 0.97 (0.11-8.30) | |
Long segment (BE ≥ 3 cm) | 1.77 (0.23-13.34) | |
Pre-study cancer history | 2.15 (0.86-5.39) | |
HGD vs non-HGD | 6.33 (2.37-16.91)b | 4.28 (1.17-15.76)a |
- Citation: Bar N, Schwartz N, Nissim M, Fliss-Isacov N, Zelber-Sagi S, Kariv R. Barrett’s esophagus with high grade dysplasia is associated with non-esophageal cancer. World J Gastroenterol 2018; 24(39): 4472-4481
- URL: https://www.wjgnet.com/1007-9327/full/v24/i39/4472.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i39.4472