Practical fecal calprotectin cut-off value for Japanese patients with ulcerative colitis

Table 1 Baseline characteristics of the 131 study patients n (%)

Parameter	n
Age, yr, median (IQR)	41 (28-52)
Man/female	67/64
Disease duration, yr, median (IQR)	3.6 (2.0-10.1)
Actual disease extent
Proctitis	29 (22.2)
Left-sided colitis	24 (18.3)
Total colitis	76 (58.0)
Segmental colitis	2 (1.5)
Partial Mayo score
< 2	93 (71.0)
2-4	28 (21.4)
5-7	8 (6.1)
> 7	2 (1.5)
Laboratory data
WBC, /μL, median (IQR)	6525 (4838-8140)
CRP, mg/dL, median (IQR)	0.1 (0.04-0.20)
ESR, mm/h, median (IQR)	7 (4-11)
Albumin, g/dL, median (IQR)	4.3 (4.0-4.6)
Hemoglobin, g/dL, median (IQR)	13.6 (12.1-14.3)
Platelets, × 1000/μL, median (IQR)	268 (190-320)
FC, μg/g, median (IQR)	289 (78-785)
Medication
Mesalazine, oral	112 (85.5)
Mesalazine, topical	12 (9.2)
Immunomodulators	47 (35.9)
Anti-TNF	21 (16.0)
Corticosteroids	17 (13.0)

CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; FC: Fecal calprotectin; IQR: Interquartile range; TNF: Tumor necrosis factor; WBC: White blood cell.

Table 2 Clinical characteristics of relapsed and non-relapsed patients n (%)

Parameter	Relapsed patients (n = 19)	Non-relapsed patients (n = 69)	P value
Age, yr, median (IQR)	35 (23-53)	40 (29-52)	0.26
Male/female	6/13	37/32	0.08
Actual disease extent
Proctitis	5 (26.3)	18 (26.1)	0.53
Left-sided colitis	1 (5.3)	12 (17.4)
Total colitis	13 (68.4)	38 (55.1)
Segmental colitis	0 (0)	1 (1.4)
Laboratory data
WBC, /μL, median (IQR)	6130 (5110-7745)	5585 (4640-7013)	0.48
CRP, mg/dL, median (IQR)	0.05 (0.01-0.10)	0.1 (0.04-0.14)	0.05
ESR, mm/h, median (IQR)	6 (4-8)	5 (3.0-10.0)	0.69
Albumin, g/dL, median (IQR)	4.4 (4.3-4.6)	4.4 (4.1-4.6)	0.75
Hemoglobin, g/dL, median (IQR)	13.3 (12.3-14.4)	13.9 (12.6-14.9)	0.25
Platelets, × 1000/μL, median (IQR)	238 (214-339)	256 (213-294)	0.92
FC, μg/g, median (IQR)	303 (94-846)	126 (55.5-485)	0.05
Medication
Mesalazine, oral	14 (73.7)	64 (92.8)	0.03
Mesalazine, topical	1 (5.3)	3 (4.3)	0.87
Immunomodulators	6 (31.6)	18 (26.1)	0.98
Anti-TNF	4 (21.1)	12 (17.4)	0.71
Corticosteroids	3 (15.8)	5 (7.2)	0.28

CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; FC: Fecal calprotectin; IQR: Interquartile range; TNF: Tumor necrosis factor; WBC: White blood cell.

Table 3 Test characteristics of fecal calprotectin levels to predict relapse and remission

Variable	Cut-off value (μg/g)	AUC	95%CI	Sensitivity (%)	Specificity(%)	PPV (%)	PLR	Accuracy (%)
Relapse	175	0.648	0.517-0.778	68	61	33	1.75	63
PMS 0	289	0.796	0.714-0.878	72	84	88	4.48	76
MES 0	490	0.823	0.707-0.939	100	62	42	2.6	70
REI 0	288	0.78	0.658-0.903	100	70	32	3.38	74
UCEIS 0	288	0.777	0.645-0.909	88	71	37	3.06	74
Riley’s score 0	125	0.881	0.780-0.981	80	86	62	5.76	85
Matts grade 1	123	0.918	0.831-1.000	88	87	58	6.65	87

AUC: Area under the curve; CI: Confidence interval; PPV: Positive-predictive value; PLR: Positive likelihood ratio; PMS: Partial Mayo score; MES: Mayo endoscopic subscore; REI: Rachmilewitz endoscopic index; UCEIS: Ulcerative colitis endoscopic index of severity.