Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis

Table 1 Patient demographics and clinical features

Feature	Data
Study patients	67
Age (yr)	40 (27-73)
Male sex	46 (70)
Disease duration (yr)	17 (8-51)
Age at diagnosis (yr)	25 (12-59)
Colitis activity index score2	0 (0-8)
Primary sclerosing cholangitis	3 (5), missing n = 2
Colorectal cancer in first degree relative	3 (5), missing n = 5
Previous dysplasia in colon	3 (5), missing n = 3
Treatment
Aminosalicylate1	58 (92), missing n = 3
Steroids1	12 (18), missing n = 4
Azathioprine1	4 (6)
Antitumour necrosis factor1	4 (6), missing n = 1

¹At time of surveillance colonoscopy and/or during past two years;

²Simple clinical colitis activity index. Data are presented as n (%) or median (interquartile range).

Table 2 Histologic diagnosis of the seven neoplastic lesions detected among the 67 total patients with long-standing and extensive ulcerative colitis

Sex	Age (yr)	LGD		HGD	Adenocarcinoma	Total
		Targeted biopsy	Nontargeted biopsy	Targeted biopsy	Targeted biopsy
Male	34	1	7	4	11	13
Male	67				12	1
Male	49	1	1			2
Male	33	1				1
Female	36	1				1
Male	44		1			1
Female	52		2			2
Total		4	11	4	2	21

¹Adenocarcinoma stage T3N1MO in patient with primary sclerosing cholangitis;

²Adenocarcinoma stage T2N0M0. No neoplasia was found in biopsies despite high suspicion of malignancy at endoscopy. Adenocarcinoma was subsequently verified in the resected surgical specimen. LGD: Low-grade dysplasia; HGD: High-grade dysplasia.

Table 3 Morphology and histology findings for the 16 bioptic sites of the 67 total patients with long-standing and extensive ulcerative colitis

Morphology	Histology	n
Targeted biopsy
Nonpolypoid
Flat lesion	No neoplasia	26
	LGD	2
	HGD	11
Superficial elevated	No neoplasia	10
	HGD	11
	Adenocarcinoma	1
Polypoid
Pedunculated	No neoplasia	1
	LGD	1
Nonpedunculated	LGD	1
Sessile with central ulceration	HGD	21
Sessile	Adenocarcinoma	11
	IND	1
Nontargeted biopsy
	No neoplasia	307
	LGD	11
Total		366

¹Concomitant primary sclerosing cholangitis. HGD: High-grade dysplasia; IND: Indefinite dysplasia; LGD: Low-grade dysplasia.

Table 4 Histologic grade of inflammation in the biopsies taken from all 67 patients

	Grade of inflammation
	Mayo 01	Mayo 1	Mayo 2	Mayo 3	No signs of previous inflammation	Total
No dysplasia/IND	133	83	33	3	93	345
LGD	3	12	0	0	0	15
HGD	0	2	2	0	0	4
CRC	0	1	1	0	0	2
Total	136	98	36	3	93	366

¹Inactive colitis. CRC: Colorectal cancer; HGD: High-grade dysplasia; IND: Indefinite dysplasia; LGD: Low-grade dysplasia.