Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line

Table 1 Immunohistochemically analysis of primary tumor

Immunohistochemistry
Cytokeratin 20	Positive
Pan cytokeratin MNF116	Positive
Synaptophysin	Positive
Chromogranin	Negative
CEA	Negative

Table 2 Measured IC₅₀ values and selected human plasma reference levels of analyzed chemotherapeutic agents

Drug	IC50	Plasma reference
5-FU	10.53 μg/mL	50 μg/mL[44]
SAHA	0.249 μg/mL
Oxaliplatin	701 ηg/mL	2 μg/mL[45]
Folfox	5.48 μg/mL + 137.1 ηg/mL
Irinotecan	0.745 μg/mL	1 μg/mL[46]
Folfiri	1 μg/mL + 0.674 μg/mL
Rapamycin	4.8 μg/mL	5-100 mg/L[47]

References for human plasma levels are set in brackets. SAHA: Suberoylanilide hydroxamic acid.