Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats

Table 1 Cytokines associated with the development of ulcerative colitis (up-regulated)

Cytokine (up)	FC (M/N)	P value	Cytokine (up)	FC (M/N)	P value
FGF-BP	1.362082	0.02	FADD	2.012878	0.15
IL-5	1.383255	0.12	B7-1	2.121888	< 0.00
MIG-6	1.502947	0.01	Fas	2.133077	0.03
IL-10	1.538953	0.04	E-Selectin	2.193775	0.35
Fractalkine	1.562316	0.01	SPP1	2.286921	0.02
PDGF-AA	1.621171	0.05	IL-2	2.298734	0.01
β-Catenin	1.63583	< 0.000	Activin A	2.328823	0.01
FSL1	1.645565	0.004	IL-3	2.356267	0.08
AMPKα1	1.747397	0.001	ADFP	2.429592	< 0.00
RAGE	1.778351	0.02	Fas Ligand	2.476364	0.02
BDNF	1.800268	< 0.00	Neuropilin-2	2.742889	0.02
IC-1	1.812053	0.39	NGFR	3.519845	< 0.00
Insulin	1.917783	0.03	IL-1Rrp2/IL-1R6	3.668512	< 0.00
ACTH	1.919645	0.15	Orexin A	4.768017	0.01
PK1	1.956145	0.08	IL-1β	5.017418	< 0.000

FC: Fold change; M/N: Average of normalized result in the model group/average of normalized result in the normal group.

Table 2 Cytokines associated with the development of ulcerative colitis (down-regulated)

Cytokine (down)	FC (M/N)	P value	Cytokine (down)	FC (M/N)	P value
MuSK	0.025485	0.26	GM-CSF	0.558641	0.01
MMP-13	0.191098	0.50	TRAIL	0.561294	0.73
ICK	0.206558	0.99	GH	0.583295	0.11
IFN-γ	0.210272	0.60	TLR4	0.605775	0.09
TNF-α	0.232403	0.54	CCR4	0.614899	0.15
IL-1α	0.283395	0.64	VEGF	0.630412	0.62
MIP-3α	0.297499	0.82	TIMP-2	0.636711	0.48
EGFR	0.362763	0.82	TGF-β1	0.644985	0.19
MMP-2	0.366125	0.94	CD106	0.6635	0.04
MIF	0.441963	0.52	ICAM-1	0.701176	0.3
MIP-1α	0.446228	0.69	Thrombospondin	0.708378	0.09
Ubiquitin	0.485159	0.59	IDE	0.711151	0.27
TIMP-3	0.489656	0.65	β-NGF	0.727731	0.13
MIP-2	0.513305	0.68	IC-3	0.748519	0.66
TIE-2	0.528072	0.81	MDC	0.749424	0.13
TGF-β3	0.550782	0.08	VEGF-C	0.768934	0.42
Growth hormone R	0.553239	0.50	CNTF	0.769193	0.02

FC: Fold change; M/N: Average of normalized result in the model group/average of normalized result in the normal group.

Table 3 Cytokines associated with the action of herb-partitioned moxibustion (down-regulated)

Cytokine (down)	FC (H/M)	P value	Cytokine (down)	FC (H/M)	P value
basic-FGF	0.0978	0.70	MCP-1	0.322376	0.71
β-Catenin	0.099918	0.03	PDGF-AA	0.329641	0.13
IL-1Rrp2/IL-1R6	0.157933	0.03	TGF-β3	0.335626	0.50
Resistin	0.165169	0.45	FADD	0.338264	0.33
B7-1/CD80	0.165526	0.02	Prolactin R	0.352073	0.57
Activin A	0.169884	0.23	IL-10	0.353484	0.23
IL-1β	0.181118	0.01	IL-3	0.354765	0.15
NGFR	0.205767	0.02	FSL1	0.374421	0.06
β-NGF	0.206263	0.52	PK1	0.374728	0.22
ACTH	0.206715	0.50	CINC-2 α/β	0.375162	0.76
AMPKα1	0.218363	0.01	FGF-BP	0.378172	0.21
CSK	0.220766	0.54	ICAM-1	0.379167	0.45
GFRα-2	0.222922	0.65	TAL1A	0.379464	0.52
CCR4	0.229987	0.26	CNTF Rα	0.380412	0.57
MIG-6	0.234297	0.22	IL-13	0.381048	0.52
Neuropilin-2	0.23433	0.04	IL-12	0.395678	0.55
Fractalkine	0.238117	0.39	CXCR4	0.397749	0.92
CD106	0.238859	0.32	IL-4	0.400025	0.30
GFRα-1	0.248202	0.66	CINC-3	0.404805	0.89
Orexin A	0.256555	0.01	MDC	0.417278	0.50
GM-CSF	0.259198	0.16	IL-5	0.41803	0.33
TGF-β2	0.261203	0.58	E-Selectin	0.424327	0.43
LIX	0.270135	0.91	Hepassocin	0.428314	0.61
BDNF	0.270917	0.06	GH	0.441903	0.02
RAGE	0.27422	0.24	Integrin αMβ2	0.458492	0.03
Leptin (OB)	0.276614	0.79	IL-6	0.47843	0.60
SPP1	0.278682	0.07	TGF-β1	0.511556	0.12
TIMP-1	0.280948	0.88	MMP-8	0.525606	0.65
L-Selectin	0.283725	0.91	GH R	0.581019	0.17
Fas	0.289612	0.06	TIMP-2	0.581976	0.31
RELMβ	0.290633	0.47	VEGF-C	0.610166	0.54
ADFP	0.290674	0.01	IC-1	0.639561	0.12
Acrp30	0.291541	0.81	IDE	0.678174	0.01
IP-10	0.295663	0.88	TIMP-3	0.69365	0.16
IL-2	0.298121	0.03	MIP-2	0.713848	0.13
Insulin	0.305481	0.09	MIF	0.725496	0.18
CNTF	0.310717	0.10	Ubiquitin	0.73656	0.09
Fas Ligand	0.319733	< 0.05	MIP-1α	0.761068	0.09
Thrombospondin	0.322261	0.55	VEGF	0.765926	0.13

FC: Fold change; H/M: Average of normalized result in the herb-partitioned moxibustion group/average of normalized result in the model group.

Table 4 Cytokines associated with the action of herb-partitioned moxibustion (up-regulated)

Cytokine (up)	FC (H/M)	P value	Cytokine (up)	FC (H/M)	P value
EGFR	1.335106	0.13	TNF-α	1.937065	0.04
TROY	1.34044	0.31	IFN-γ	2.000647	0.01
TLR4	1.511846	0.04	MMP-13	2.19335	0.04
IC-3	1.664604	0.74	MuSK	12.24563	0.02
IL-1α	1.845212	0.01

FC: Fold change; H/M: Average of normalized result in the herb-partitioned moxibustion group/average of normalized result in the model group.