Apoptosis and non-alcoholic fatty liver diseases

Table 1 Inhibitors of apoptosis for nonalcoholic steatohepatitis

Drug and reagents	Targets	Mechanism of action	Ref.
Triacsin C	Intracellular long-chain acyl-CoA synthetases (ACSL)	Triacylglycerol (TAG) accumulation into lipid droplets	[112]
Ezetimibe	AMPK phosphorylation	TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition	[113]
Baicalin	Inhibition of NF-κB	NF-κB anti-inflammation signaling pathways	[114]
Granulocyte colony stimulating factor (G-CSF)	PI3K/Akt	Activation of PI3K and Akt pathway	[115]
Elafibranor (GFT505)	PPARα/δ	Agonist of PPARα/δ receptors	[116]
Isoquercitrin	Dipeptidyl peptidase-IV(DPP-IV)	Activation of glucagonlike peptide-1 (GLP-1)	[117]
Activated carbon N-acetylcysteine (ACNAC) microcapsules	Telomerase	Improved telomerase activity	[118]
3-Acetyl-oleanolic acid (3Ac-OA)	Glucose transporter type 2 (GLUT-2), low-density lipoprotein receptor (LDLR)	AMPK-related pathways	[119]
Meretrix oligopeptides (MMO)	NF-κB	NF-κB anti-inflammation signaling pathways	[120]
Seladelpar (MBX-8025)	Proliferator-activated receptor- delta (PPAR-δ)	Selective PPAR-δ agonist	[121]
Resveratrol	Sirt1	Antioxidant	[122]
TBE-31	NF-E2 p45-related factor 2 (Nrf2)	Regulation of intracellular redox homeostasis	[124]