Safety and efficacy of metallic stent for unresectable distal malignant biliary obstruction in elderly patients

Table 1 Patient background

	< 80 yr old (Group A)	≥ 80 yr old (Group B)	P value
Number of patients	184	88
Male	105	52	NS
Female	79	36	NS
Pancreatic cancer	136	72	NS
Bile duct cancer	21	9	NS
Metastatic biliary obstruction	13	3	NS
Papilla vater cancer	6	3	NS
Gallbladder cancer	6	1	NS
Intraductal papillary mucinous carcinoma	1	0	NS
Hepatocellular carcinoma	1	0	NS
Hepatic metastasis	40	16	NS
Ascites	45	23	NS
Duodenal stent indwelling	30	10	NS
Pathological diagnosis	161	89	NS
Performance status
0	72	8	0.0000
1	7	3	NS
2	44	12	0.018
3	29	37	0.0004
4	32	28	0.0064
Chemotherapy	106	15	0.0000
Hypertension	55	52	0.0002
Hyperlipidemia	20	6	NS
Diabetes mellitus	50	31	NS
Chronic respiratory disease	25	18	NS
Cardiac disease	18	20	0.0065
Chronic liver disease	18	6	NS
Chronic renal disease	10	3	NS
Cerebrovascular disease	5	20	0.0000
Dementia	5	20	0.0000
Anticoagulant/antiplatelet	9	23	0.0270

NS: Not significant.

Table 2 Treatment effect judgment

Drainage effect	< 80 yr old (Group A; n = 184)	≥ 80 yr old (Group B; n = 88)	P value
Bile duct diameter prior to drainage (mm)	11.350 ± 3.6310 (4-23)	12.819 ± 3.3148 (5-22)	NS
Stenosis length prior to drainage (mm)	27.216 ± 12.688 (5-59)	27.292 ± 12.702(6-52)	NS
ALT prior to drainage (IU/L)	162.767 ± 104.768 (29-851)	127.567 ± 104.760(30-838)	NS
ALT post drainage (IU/L)	78.875 ± 159.482 (10-278)	66.039 ± 143.106 (13-270)	NS
ALP prior to drainage (IU/L)	1529.375 ± 1465.465 (409-2620)	1489.447 ± 1102.192 (432-2512)	NS
ALP post drainage (IU/L)	871.000 ± 803.131 (326-1855)	665.622 ± 557.643 (331-1811)	NS
T-Bil prior to drainage (mg/dl)	5.438 ± 6.512 (0.4-27.8)	5.276 ± 5.858 (0.6-27)	NS
T-Bil post drainage (mg/dl)	2.387 ± 3.879 (0.4-12.2)	1.580 ± 3.943 (0.6-12)	NS
Chemotherapeutic effect
CR	0	0	NS
PR	12	4	NS
SD	78	7	0.0000
PD	16	4	NS
Total	106	15	0.0000
Best supportive care	78	73	0.0000

NS: Not significant.

Table 3 Cause of metallic stent obstruction

Related complications	< 80 yr old(Group A; n = 184)	≥ 80 yr old(Group B; n = 88)	P value
Overgrowth	10	7	NS
Ingrowth	6	0	NS
Sludge	16	10	NS
Stent migration	15	8	NS
Food impaction	3	4	NS
Others	3	0	NS
Total	53	29	NS

NS: Not significant.

Table 4 Comparison of early procedural accidents after conducting endoscopic retrograde cholangiopancreatography

Related complications	< 80 yr old(Group A; n = 184)	≥ 80 yr old(Group B; n = 88)	P value
Bleeding	0	0
Perforation	0	0	NS
Pancreatitis	7 (mild)	1 (mild)	0.003
Cholangitis	1 (mild)	2 (mild)	NS
Cholecystitis	8 (6 mild, 2 moderate)	2 (mild)	NS
Stent migration	1	0	NS
Pneumoniae	0	2	NS

NS: Not significant.