Clinicopathological and prognostic significance of aberrant Arpin expression in gastric cancer

Table 1 Association analysis of immunohistochemistry staining for Arpin vs clinicopathological factors of gastric cancer, n (%)

Clinicopathological features	Number of patients (n = 176)	Arpin expression		χ2	P value
		High (n = 54)	Low (n = 122)
Age (yr)
> 50	97 (55.11)	29 (29.90)	68 (70.10)	0.063	0.802
≤ 50	79 (44.89)	25 (31.65)	54 (68.35)
Gender
Male	110 (62.50)	31 (28.18)	79 (71.82)	0.865	0.353
Female	66 (37.50)	23 (34.85)	43 (65.15)
Tumer size (cm)
> 5	120 (68.18)	37 (30.83)	83 (69.17)	0.004	0.949
≤ 5	56 (31.82)	17 (30.36)	39 (69.64)
Depth of invasion
T1 + T2	44 (25.00)	24 (54.55)	20 (45.45)	15.79	0.000
T3 + T4	132 (75.00)	30 (22.73)	102 (77.27)
Lymph node metastasis
Yes	131 (74.43)	25 (19.08)	106 (80.92)	32.404	0.000
No	45 (25.57)	29 (64.44)	16 (35.56)
TNM stage
I	70 (39.77)	30 (42.86)	40 (57.14)	9.379	0.009
II	50 (28.41)	14 (28.00)	36 (72.00)
III	56 (31.82)	10 (17.86)	16 (82.14)
Histology
Well + moderate	80 (45.45)	21 (26.25)	59 (73.75)	1.354	0.245
Poor	96 (54.55)	33 (34.38)	63 (65.62)
Tumor site
Upper	66 (37.50)	24 (36.36)	42 (63.64)	1.648	0.439
Middle	16 (9.09)	4 (25.00)	12 (75.00)
Low	94 (53.41)	26 (27.66)	68 (72.34)

Table 2 Immunohistochemistry staining for Arpin in gastric cancer and normal gastric tissues, n (%)

Group	No. of patients	Arpin expression		χ2	P value
	(n = 219)	High (n = 80)	Low (n = 139)
Normal	43	26 (60.47)	17 (39.53)	13.221	< 0.001
Cancer	176	54 (30.68)	122 (69.32)

Table 3 Association analysis of expression of Arpin protein vs TNM stage of gastric cancer, n (%)

TNM stage	No. of patients	Arpin expression		P value
		High (n = 54)	Low (n = 122)
I	70 (39.77)	30 (42.86)	40 (57.14)	0.0961
II	50 (28.41)	14 (28.00)	36 (72.00)	0.2132
III	56 (31.82)	10 (17.86)	46 (82.14)	0.0033

¹Stage I vs II;

²Stage II vs III;

³Stage I vs III.

Table 4 Correlation of Arpin and Arp2/3 complex expressions in gastric cancer patients

Arp2/3 complex	Arpin		χ2	P value
	High (n = 54)	Low (n = 122)
Positive (n = 114)	27	87	30.535	0.000
Negative (n = 62)	27	35

McNemar χ² = 30.535, P = 0.000.

Table 5 Univariate and multivariate survival analysis of 3-year DFS in 176 patients with gastric cancer

Variable	Univariate analysis		Multivariate analysis
	HR	P value	HR	P value
Age	1.14	0.488
Gender	1.373	0.098
tumor size	1.411	0.08
Depth of invasion	1.818	0.017	1.117	0.732
Lymph node metastasis	2.498	0.035	1.413	0.225
tumor site	1.336	0.612
TNM stage	4.985	< 0.001	5.344	0.001
Arpin expression	0.494	0.005	0.551	0.029