Surgery for gastric cancer patients of age 85 and older: Multicenter survey

Table 1 Patient characteristics and perisurgical outcomes n (%)

	Total patients (n = 134)
Age (yr)	87.4 (85-97)
Sex (male/female)	77/57
Post-operative hospital stay (d)	29 (9-305)
Comorbidity	89 (66.0)
Hypertension	52 (39.0)
Cardiovascular disease	36 (27)
Respiratory disease	13 (9.7)
Cerebrovascular disease	9 (6.7)
Diabetes mellitus	13 (9.7)
Renal dysfunction	4 (3.0)
Other	4 (3.0)
Number of comorbidities
0	45
1/2	63/18
3/4	6/2
Operation
Distal	84
Proximal	5
Total	34
Partial	4
Bypass	4
Unresectable	3
Procedure
Open	122
Laparoscopy	12
Lymphadenectomy
D0/D1	17/52
D1+/D2	40/25
Lymphadenectomy
Radical/limited	59/75
Number of resected LN	23 (0-67)
Operative time (min)	206 (62-426)
Bleeding (g)	263 (10-1855)
Residual tumor
R0/1/2	103/10/21

LN: Lymph node.

Table 2 Pathological features and complications n (%)

	Total patients, n =134
Location	L/M/U	59/51/24
Macroscopic type	0/1/2/3/4/5/unknown	35/8/35/25/10/3/18
cT	1-2/3-4	64/70
cN	-/+	70/64
cStage	I/II/III/IV	54/36/32/12
pT	1-2/3-4	62/72
pN	-/+/unknown	59/68/7
pStage	I/II/III/IV	49/29/39/17
Differentiation	Well/moderate/poor/unknown	46/17/55/16
Lymphatic invasion	- +/unknown	38/79/17
Venous invasion	-/+/unknown	55/62/17
Complications	-/+	94/40
	Surgical site infection	11 (8.2)
	Anastomotic leakage	12 (9.0)
	Anastomotic stenosis	4 (3.0)
	Pneumonia	7 (5.2)
	Pancreatic fistula	3 (2.2)
	Intestinal hypoperistalsis	2 (1.5)
	Cardiac complication	1 (0.7)
	Brain complication	1 (0.7)
	Other	2 (1.5)

L/M/U: Lower third/middle third/upper third.

Table 3 Univariate and multivariate analyses for survival

	n = 113	5-yr survival	Univariate	Multivariate
			P value	HR	95%CI	P value
Sex
Male	65	33	0.17	-
Female	48	48
Comorbidities
< 2	93	35	0.35	-
≥ 2	20	63
Operation
Total	29	36	0.13	-
Others	84	41
Procedure
Open	101	37	0.10	-
Laparoscopy	12	62
Lymphadenectomy
Radical	59	43	0.01	1.00	1.00-4.97	0.05
Limited	54	35		2.19
Operative time (min)
< 240	76	32	0.34	-
≥ 240	33	58
Unknown	4
Bleeding (g)
< 400	91	40	0.12	-
≥ 400	18	27
Unknown	4
cT
1-2	63	49	< 0.01	1.16	0.41-3.23	0.78
3-4	50	27		1.00
cN
Absent	67	45	0.43	-
Present	46	35
cStage
I-II	87	40	0.59	-
III- IV	26	37
pT
1-2	62	58	< 0.01	1.00	1.29-20.7	0.02
3-4	51	16		4.68
pN
Absent	58	56	< 0.01	1.00	0.68-5.62	0.24
Present	55	23		1.84
pStage
I-II	78	55	< 0.01	-
III- IV	35	9
Residual tumor
R0	103	41	0.06	1.14	0.39-3.87	0.81
R1	10	31		1.00
Lymphatic invasion
Absent	37	55	0.09	1.49	0.43-5.10	0.53
Present	67	29		1.00
Unknown	9
Venous invasion
Absent	53	58	< 0.01	1.00	0.75-5.80	0.17
Present	51	15		2.00
Unknown	9
Complications
Absent	81	34	0.31	-
Present	32	51

Table 4 Relationships between lymphadenectomy and clinicopathlogical features

	n = 113	Lymphadenectomy		P value
		Radical	Limited
Comorbidity
Present	75	45	30	0.02
Absent	38	14	24
Hypertension
Present	43	28	15	0.03
Absent	70	31	39
Cardiovascular disease
Present	31	14	17	0.36
Absent	82	45	37
Respiratory disease
Present	11	7	4	0.42
Absent	102	52	50
Cerebrovascular disease
Present	6	1	5	0.07
Absent	107	58	49
Diabetes mellitus
Present	12	7	5	0.65
Absent	101	52	49
Renal dysfunction
Present	3	3	0	0.09
Absent	110	56	54
Number of comorbidities
< 2	93	47	46	0.44
≥ 2	20	12	8
cStage
I-II	87	45	42	0.85
III- IV	26	14	12
Operation
Total	29	14	15	0.62
Other	84	45	39