Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation

Table 1 Expression of cyclooxygenase-2 was more likely to be associated with the expression of activating transcription factor 6 than with inositol-requiring enzyme-1 and protein kinase RNA-like endoplasmic reticulum kinase in hepatocellular carcinoma patients

COX-2	AFP-6				IRE-1				PERK
	-	+	r	P value	-	+	r	P value	-	+	r	P value
Negative	16	39	0.198	0.011	30	25	0.135	0.086	29	26	0.017	0.134
Positive	14	95			44	65			44	65

ATF-6: Activating transcription factor 6; COX-2: Cyclooxygenase-2; IRE: Inositol-requiring enzyme; PERK: Protein kinase RNA-like endoplasmic reticulum kinase.