Disease impact on the quality of life of children with inflammatory bowel disease

Table 1 Demographic data, disease characteristics and medications at the time of the evaluation n (%)

	Overall (n = 99)	CD (n = 62)	UC (n = 37)	P value
Gender, females	59 (59.6)	32 (51.6)	27 (73.0)	0.063
Age (yr)	12.8 ± 2.6	13.4 ± 2.4	11.6 ± 2.5	0.0011
Age at diagnosis (yr)	9.9 ± 3.1	10.7 ± 2.9	8.6 ± 3.0	< 0.0011
Number of hospitalizations4	2 (1-4)	2 (1-4)	3 (1-6)	0.092
Disease duration at IMPACT completion (yr)	2.8 ± 2.6	2.7 ± 2.5	3.0 ± 2.7	0.481
Disease activity	NA	7.2 ± 10.3	14.0 ± 20.5	NA
Disease status, in remission	70 (70.7)	45 (72.6)	25 (67.6)	0.653
Physician global assessment				0.93
Clinical remission	80 (80.8)	50 (80.6)	30 (81.1)
Mild	14 (14.1)	9 (14.5)	5 (13.5)
Moderate	5 (5.1)	3 (4.8)	2 (5.4)
Medications at IMPACT completion
Antibiotics	2 (2.0)	2 (3.2)	0 (0.0)	0.523
Steroids	39 (39.4)	24 (38.7)	15 (40.5)	0.993
Immunomodulators	68 (68.7)	47 (75.8)	21 (56.8)	0.113
Biologic agents	31 (31.3)	25 (40.3)	6 (16.2)	0.033
Enteral nutrition	0 (0.0)	0 (0.0)	0 (0.0)	NA
Aminosalicylates	52 (52.5)	15 (24.2)	37 (100.0)	< 0.0013

¹t-test;

²Mann-Whitney test;

³Fisher’s exact test;

⁴Three months prior to completing IMPACT, median (interquartile range). NA: Not applicable; CD: Crohn’s disease; UC: Ulcerative colitis.

Table 2 IMPACT scores (total and domain scores) in the study population

	Overall (n = 99)	CD (n = 62)	UC (n = 37)	P value1
Total score	76.2 ± 12.1	77.5 ± 11.2	73.9 ± 13.3	0.16
Individual domains
Bowel symptoms	76.6 ± 14.8	78.0 ± 14.0	74.2 ± 15.5	0.22
Systemic symptoms	80.8 ± 17.4	82.0 ± 16.7	78.8 ± 18.5	0.36
Emotional functioning	72.4 ± 19.0	75.2 ± 18.3	67.9 ± 19.6	0.06
Social functioning	79.9 ± 12.4	80.6 ± 12.0	78.6 ± 13.0	0.42
Body image	71.5 ± 17.9	72.6 ± 19.3	69.8 ± 15.4	0.46
Treatment/interventions	69.0 ± 19.9	70.0 ± 18.4	67.3 ± 22.4	0.51

¹t-test. CD: Crohn’s disease; UC: Ulcerative colitis.

Table 3 IMPACT scores per domain according to physician’s global assessment classification (total population)

Domain	PGA		P value1
	Clinical remission	Mild/moderate
Bowel symptoms	80.0 ± 13.3	62.4 ± 11.8	< 0.001
Systemic symptoms	84.2 ± 16.0	66.6 ± 15.9	< 0.001
Emotional functioning	75.8 ± 18.6	58.3 ± 13.5	< 0.001
Social functioning	82.5 ± 11.0	69.0 ± 11.9	< 0.001
Body image	73.2 ± 17.9	64.5 ± 16.4	0.032
Treatment/interventions	70.9 ± 20.1	61.0 ± 17.1	0.007

¹Mann-Whitney test. PGA: Physician’s global assessment.

Table 4 IMPACT scores per domain according to physician’s global assessment classification (Crohn’s disease patients)

Domain	PGA		P value1
	Clinical remission	Mild/moderate
Bowel symptoms	77.4 ± 15.1	60.7 ± 9.2	0.007
Systemic symptoms	82.8 ± 17.6	61.9 ± 11.6	0.002
Emotional functioning	70.0 ± 21.1	58.7 ± 4.5	0.050
Social functioning	80.8 ± 12.7	69.0 ± 10.0	0.032
Body image	70.3 ± 16.6	67.9 ± 8.9	0.600
Treatment/interventions	68.9 ± 24.2	60.7 ± 11.5	0.300

¹Mann-Whitney test. PGA: Physician’s global assessment.

Table 5 IMPACT scores per domain according to physician’s global assessment classification (ulcerative colitis patients)

Domain	PGA		P value1
	Clinical remission	Mild/moderate
Bowel symptoms	81.6 ± 12.1	63.4 ± 13.4	< 0.001
Systemic symptoms	85.0 ± 15.1	69.4 ± 17.9	0.005
Emotional functioning	79.3 ± 16.2	58.0 ± 16.9	< 0.001
Social functioning	83.4 ± 9.9	68.9 ± 13.2	0.001
Body image	75.0 ± 18.6	62.5 ± 19.6	0.036
Treatment/interventions	72.2 ± 17.5	61.1 ± 20.2	0.070

¹Mann-Whitney test. PGA: Physician’s global assessment.