Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture

Table 1 Clinical data of all patients with suspicion for IgG4-related disease (Pat1-Pat3) or eosinophilic cholangitis (Pat4-Pat6)

Patient ID	Age	Sex	Year	Eos (histology)	Eos (serum)	IgG4-staining	Biliary stenosis	Clinical course
Pat1	40	M	2008	+	-	+	Perihilar	Hemihepatectomy
Pat2	52	M	2011	+	-	+	Perihilar	Hemihepatectomy
Pat3	73	M	2005	-	NA	+	Perihilar	CBD-resection
Pat4	40	F	2015	+	-	-	Distal	Steroids
Pat5	63	M	2008	+	-	-	Distal	PPPD
Pat6	65	F	2006	+	-	-	Perihilar	CBD-resection

Eosinophilic infiltrate was assessed as positive, if ≥ 15 eosinophilic granulocytes/high power field were present. Cut off for peripheral eosinophilia was ≥ 4% of leukocytes. Plasma cells were assessed as positive, if > 30% stained positive for IgG4. CBD: Common bile duct; PPPD: Pylorus preserving pancreaticoduodenectomy; Year: The year the histological specimen was obtained; Eos: Eosinophilic granulocytes; na: Not available.