Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy

Table 1 Univariate and multivariate analyses of potential risk factors for alveolar echinococcosis recurrence (Cox regressions)

	Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Leukocytes > 9 g/L	1.572	0.171-14.454	0.690
MCV > 90 fl	0.298	0.034-2.647	0.278
RDW > 14 %	0.444	0.080-2.461	0.353
Thrombocytes > 300 g/L	0.044	0.001-68’792	0.692
CRP > 20 mg/mL	1.061	0.171-6.567	0.949
Hemoglobin > 130 g/L	0.789	0.132-4.738	0.796
Bilirubin > 10 μmol/L	0.242	0.040-1.472	0.124
Albumin > 37.5 g/L	0.078	0.015-0.415	0.003	0.099	0.018-0.530	0.007
R0 resection	0.137	0.027-0.711	0.018	0.182	0.034-0.962	0.045
Lesion size > 5 cm	3.342	0.385-28.998	0.274
PV invasion1	3.564	0.769-16.511	0.104

¹Defined as presence of microscopic invasion of the PV by alveolar echinococcosis on histopathological reports. CRP: C-reactive protein; MCV: Mean corpuscular volume; PV: Portal vein; RDW: Red blood cell distribution width.

Table 2 Disease-free survival of patients according to various peri-operative criteria

	Median DFS, mo (IQR)	P value
Leukocytes > 9 g/L	65 (6-81)	0.545
Leukocytes ≤ 9 g/L	58 (23-107)
MCV > 90 fl	69 (29-121)	0.116
MCV ≤ 90 fl	58 (15-92)
RDW > 14%	68 (28-117)	0.154
RDW ≤ 14%	56 (8-81)
Thrombocytes > 300 g/L	68 (30-128)	0.510
Thrombocytes ≤ 300 g/L	58 (18-102)
CRP > 20 mg/mL	68 (13-105)	0.325
CRP ≤ 20 mg/mL	50 (9-74)
Hemoglobin > 130 g/L	65 (25-111)	0.440
Hemoglobin ≤ 130 g/L	41 (13-107)
Bilirubin > 10 μmol/L	60 (12-129)	0.488
Bilirubin ≤ 10 μmol/L	44 (25-81)
Albumin > 37.5 g/L	56 (26-79)	0.048
Albumin ≤ 37.5 g/L	25 (13-57)
R0 resection	69 (27-129)	0.024
R1 resection	41 (12-92)
Lesion size > 5 cm	65 (8-102)	0.733
Lesion size ≤ 5 cm	50 (25-114)
PV invasion1	56 (7-130)	0.933
No PV invasion	60 (25-105)

¹Defined as presence of microscopic invasion of the PV by alveolar echinococcosis on histopathological reports. CRP: C-reactive protein; DFS: Disease-free survival; IQR: Interquartile range; MCV: Mean corpuscular volume; PV: Portal vein; RDW: Red blood cell distribution width.