Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Table 1 Univariate analysis of correlation between lymph node metastasis and clinicopathological parameters of T1-stage colorectal cancer patients

Clinicopathological characteristic	n	Lymph node metastasis		χ2	P value
		Yes	No
Gender				1.955	0.162
Male	172	11	161
Female	149	16	133
Age (yr)				0.436	0.509
≥ 60	174	13	161
< 60	147	14	133
Smoking				0.766	0.382
No	279	22	257
Yes	42	5	37
Preoperative CEA (ng/mL)				5.994	0.014
< 5	284	20	264
≥ 5	37	7	30
Preoperative CA199 (ng/mL)				5.015	0.025
< 9	173	9	164
≥ 9	148	18	130
Preoperative CA724 (ng/mL)				12.275	0.000
< 2	163	5	158
≥ 2	158	22	136
Granulocyte absolute value				0.771	0.380
< 2.2	32	4	28
≥ 2.2	289	23	266
D-dimer				2.227	0.136
< 0.21	158	17	141
≥ 0.21	163	10	153
Preoperative hemoglobin				1.504	0.220
< 132	154	16	138
≥ 132	167	11	156
Vascular invasion				18.421	0.000
No	313	23	290
Yes	8	4	4
Tumor location				1.184	0.277
Rectum	170	17	153
Colon	151	10	141
Tumor size (cm)				1.526	0.217
< 3	190	19	171
≥ 3	131	8	123
Differentiation degree				7.723	0.005
High/moderate	307	23	284
Low	14	4	10
Tumor general type				0.219	0.640
Ulcer	238	19	219
Non-ulcer	83	8	75
Tumor tissue type				2.293	0.130
Non-adenocarcinoma	9	2	7
Adenocarcinoma	312	25	287

Table 2 Multivariate analysis of correlation between lymph node metastasis and clinicopathological parameters of T1-stage colorectal cancer patients

Clinicopathological characteristic	HR	P value	95%CI
			Lower bound	Upper bound
Gender, Male vs Female	1.636	0.201	0.698	5.518
Age (yr), < 60 vs ≥ 60	0.063	0.801	0.357	2.218
Smoking No vs Yes	0.880	0.348	0.529	6.077
Preoperative CEA (ng/mL) < 5 vs ≥ 5	1.188	0.276	0.603	5.904
Preoperative CA199 (ng/mL) < 9 vs ≥ 9	2.765	0.096	0.869	5.541
Preoperative CA724 (ng/mL) < 2 vs ≥ 2	5.461	0.019	1.232	10.783
Granulocyte absolute value, < 2.2 vs ≥ 2.2	0.004	0.951	0.285	3.797
D-dimer < 0.21 vs ≥ 0.21	1.398	0.237	0.651	5.652
Preoperative hemoglobin < 132 vs ≥ 132	0.437	0.508	0.249	1.992
Tumor size (cm), < 3 vs ≥ 3	2.090	0.148	0.185	1.290
Vascular invasion, No vs Yes	8.461	0.004	2.358	81.596
Tumor location, Rectum vs Colon	0.264	0.607	0.485	3.444
Differentiation degree, High/moderate vs Low	4.204	0.040	1.057	11.956
Tumor general type, Non-ulcer vs Ulcer	0.686	0.407	0.556	4.239
Tissue type, Non-adenocarcinoma vs Adenocarcinoma	0.897	0.344	0.043	2.989

Table 3 Univariate analysis of correlation between clinicopathological parameters and 5-year overall survival

Clinicopathological characteristic	n	OS rate	χ2	P value
Gender			1.225	0.268
Male	172	90.90%
Female	149	90.10%
Age (yr)			6.103	0.013
≥ 60	174	86.50%
< 60	147	95.50%
Smoking			0.429	0.513
No	279	91.00%
Yes	42	87.50%
Preoperative CEA (ng/mL)			13.594	0.000
< 5	284	92.70%
≥ 5	37	78.40%
Preoperative CA199 (ng/mL)			7.229	0.007
< 9	173	94.70%
≥ 9	148	85.70%
Preoperative CA724 (ng/mL)			0.012	0.912
< 2	163	87.40%
≥ 2	158	93.20%
Granulocyte absolute value			1.613	0.204
< 2.2	32	85.00%
≥ 2.2	289	91.00%
D-dimer			0.001	0.979
< 0.21	158	88.80%
≥ 0.21	163	91.90%
Preoperative hemoglobin			0.907	0.341
< 132	154	89.10%
≥ 132	167	91.70%
Vascular invasion			12.955	0.000
No	313	91.60%
Yes	8	40.00%
Tumor location			1.121	0.290
Rectum	170	89.80%
Colon	151	91.90%
Tumor size (cm)			0.210	0.647
< 3	190	90.00%
≥ 3	131	91.20%
Differentiation degree			6.825	0.009
High/moderate	307	91.30%
Low	14	78.60%
Tumor general type			3.149	0.207
Protruded	228	91.80%
Infiltration	10	100.00%
Ulcer	83	86.20%
Tumor tissue type			1.828	0.176
Non-adenocarcinoma	9	75.00%
Adenocarcinoma	312	91.30%
Lymph node metastasis			24.180	0.000
No	294	93.20%
Yes	27	65.20%

Table 4 COX regression analysis of correlation between clinicopathological parameters and 5-year overall survival

	RR	P value	95%CI
			Lower bound	Upper bound
Gender, Male vs Female	1.784	0.182	0.695	6.816
Age (yr), < 60 vs ≥ 60	3.805	0.051	0.995	9.034
Smoking, No vs Yes	0.590	0.442	0.413	7.565
Preoperative CEA, (ng/mL), < 5 vs ≥ 5	1.121	0.290	0.580	6.206
Preoperative CA199, (ng/mL), < 9 ≥ 9	6.452	0.011	1.411	14.481
Preoperative CA724, (ng/mL), < 2 ≥ 2	0.935	0.333	0.201	1.725
Granulocyte absolute value, < 2.2 vs ≥ 2.2	0.040	0.841	0.171	8.761
D-dimer, < 0.21 ≥ 0.21	2.373	0.123	0.777	8.217
Preoperative hemoglobin, < 132 vs ≥ 132	0.577	0.448	0.198	2.042
Tumor size (cm), < 3 vs ≥ 3	0.581	0.446	0.261	21.193
Vascular invasion, No vs Yes	0.343	0.558	0.468	4.076
Tumor location, Rectum vs Colon	0.210	0.647	0.310	2.068
Differentiation degree, High/moderate vs Low	1.031	0.310	0.435	13.792
Tumor general type, Ulcer vs Non-ulcer	2.338	0.126	0.811	5.471
Tumor tissue type, Non-adenocarcinoma vs Adenocarcinoma	0.783	0.376	0.068	2.755
Lymph node metastasis, No vs Yes	5.328	0.021	1.264	17.592