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©The Author(s) 2017.
World J Gastroenterol. Dec 28, 2017; 23(48): 8562-8569
Published online Dec 28, 2017. doi: 10.3748/wjg.v23.i48.8562
Published online Dec 28, 2017. doi: 10.3748/wjg.v23.i48.8562
Table 1 Demographic data of the 469 patients with gastric cancer, n (%)
Characteristics | CEA-Low group(n = 421) | CEA-High group( n = 48) | P value |
Age (yr), mean ± SD | 58.74 ± 10.98, 60 (20-83) | 60.4 ± 11.55, 61 (31-78) | |
Gender | |||
Female | 118 (28) | 12 (25) | 0.657 |
Male | 303 (72) | 36 (75) | |
Male-to-female ratio | 2.81:1 | 3:01 | |
Family history | |||
Positive | 8 (1.9) | 1 (2.01) | 0.930 |
Negative | 413 (98.1) | 47 (97.99) | |
HP infection status | |||
Positive | 37 (8.8) | 5 (10.4) | 0.708 |
Negative | 384 (91.2) | 43 (89.6) | |
BMI (kg/m2) | |||
Less than 18.5 | 28 (6.65) | 4 (8.33) | 0.358 |
18.5-24.99 | 304 (72.21) | 38 (79.17) | |
More than 25 | 89 (21.14) | 6 (12.5) | |
Differentiation degree | |||
Well | 226 (53.7) | 22 (45.8) | 0.302 |
Poor | 195 (46.3) | 26 (54.2) | |
Location | |||
Upper | 113 (26.8) | 16 (33.33) | 0.779 |
Middle | 129 (30.64) | 10 (20.83) | |
Lower | 168 (39.9) | 21 (43.75) | |
Mixed | 11 (2.61) | 1 (2.08) | |
Lauren classification | |||
Intestinal type | 105 (24.94) | 10 (20.83) | 0.668 |
Diffuse type | 270 (64.13) | 31 (64.59) | |
Mixed type | 46 (10.93) | 7 (14.58) | |
T category | |||
T1a | 68 (16.2) | 4 (8.3) | 0.033a |
T1b | 78 (18.5) | 5 (10.4) | |
T2 | 89 (21.1) | 13 (27.1) | |
T3 | 65 (15.4) | 14 (29.2) | |
T4a | 116 (27.6) | 10 (20.8) | |
T4b | 5 (1.2) | 2 (4.2) | |
T1 | 146 (34.68) | 9 (18.75) | 0.026a |
T2-4b | 275 (65.32) | 39 (81.25) | |
Nerve invasion | |||
Positive | 70 (16.6) | 11 (22.92) | 0.275 |
Negative | 351 (83.4) | 37 (77.08) | |
Vessel carcinoma embolus | |||
Positive | 72 (17.1) | 15 (31.35) | 0.017a |
Negative | 349 (82.9) | 33 (68.75) |
Table 2 Multivariate analysis for stage pTxN0M0 gastric cancer patients with D2 resection
Univariate analysis | Multivariate analysis | |||||||
P value | Exp(B) | 95%CI used for Exp (B) | P value | Exp (B) | 95%CI used for Exp (B) | |||
Lower | Upper | Lower | Upper | |||||
Family history | 0.912 | 0.923 | 0.765 | 1.311 | 0.069 | 1.017 | 0.72 | 1.896 |
HP infection status | 0.209 | 0.832 | 0.781 | 1.226 | 0.754 | 1.088 | 0.643 | 1.840 |
Gender | 0.000a | 1.716 | 1.316 | 2.553 | 0.590 | 0.898 | 0.608 | 1.327 |
CEA | 0.000a | 1.919 | 1.319 | 2.352 | 0.000a | 1.924 | 1.353 | 2.232 |
Location | 0.245 | 0.841 | 0.792 | 1.234 | 0.749 | 1.012 | 0.861 | 1.531 |
Lauren classification | 0.241 | 0.851 | 0.814 | 1.091 | 0.711 | 1.109 | 0.891 | 1.154 |
T category | 0.000a | 1.906 | 1.659 | 2.271 | 0.009a | 1.714 | 1.050 | 2.403 |
Differentiation degree | 0.279 | 0.932 | 0.881 | 1.126 | 0.784 | 1.188 | 0.663 | 1.640 |
Nerve invasion | 0.971 | 0.801 | 0.731 | 1.145 | 0.097 | 0.951 | 0.7768 | 1.655 |
Vessel carcinoma embolus | 0.000a | 1.764 | 1.321 | 2.562 | 0.983 | 0.994 | 0.895 | 1.660 |
BMI | 0.732 | 0.812 | 0.729 | 1.234 | 0.356 | 1.228 | 0.912 | 2.229 |
Table 3 Multivariate analysis of overall survival in pTxN0M0 gastric cancer patients
CEA-Low group (n = 421) | CEA-High group (n = 48) | |||||||
P value | Exp(B) | 95%CI | P value | Exp(B) | 95%CI | |||
Lower | Upper | Lower | Upper | |||||
Family history | 0.077 | 2.978 | 0.888 | 3.986 | 0.512 | 1.191 | 0.501 | 2.019 |
HP infection status | 0.140 | 1.590 | 0.858 | 2.947 | 0.247 | 0.522 | 0.174 | 1.570 |
Gender | 0.478 | 0.834 | 0.504 | 1.378 | 0.919 | 1.036 | 0.527 | 2.037 |
Location | 0.482 | 0.831 | 0.764 | 1.124 | 0.897 | 1.012 | 0.752 | 2.102 |
Lauren classification | 0.831 | 0.911 | 0.891 | 1.103 | 0.843 | 1.245 | 0.984 | 1.435 |
T category | 0.647 | 0.941 | 0.725 | 1.222 | 0.001a | 1.962 | 1.139 | 2.629 |
Differentiation degree | 0.879 | 0.931 | 0.811 | 1.176 | 0.884 | 1.148 | 0.673 | 1.641 |
Nerves invaded | 0.811 | 1.090 | 0.539 | 2.205 | 0.987 | 0.993 | 0.438 | 2.251 |
Vessel carcinoma embolus | 0.064 | 0.315 | 0.093 | 1.068 | 0.883 | 0.889 | 0.685 | 2.281 |
BMI | 0.392 | 0.424 | 0.851 | 1.124 | 0.356 | 1.228 | 0.912 | 2.229 |
- Citation: Xiao J, Ye ZS, Wei SH, Zeng Y, Lin ZM, Wang Y, Teng WH, Chen LC. Prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample single-center retrospective study. World J Gastroenterol 2017; 23(48): 8562-8569
- URL: https://www.wjgnet.com/1007-9327/full/v23/i48/8562.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i48.8562