Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury

doi:10.3748/wjg.v23.i46.8169

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2017; 23(46): 8169-8181
Published online Dec 14, 2017. doi: 10.3748/wjg.v23.i46.8169

Table 1 Pharmacokinetic parameters of the seven components of Shengjiang decoction

Component	Group	Tmax (h)	T_1/2 (h)	MRT (0-t) (h)	CL (L/h/kg)	Cmax (μg/L)	AUC (0-t)( μg/L/h)
Emodin	CG + SJD	0.56 ± 0.27	0.85 ± 1.09	4.13 ± 0.41	396 ± 147	16.23 ± 4.11	44.78 ± 18.87
Emodin	MG + SJD	0.50 ± 0.28	0.26 ± 0.12	3.08 ± 0.48^a	619 ± 193^a	16.47 ± 7.35	34.34 ± 14.78
ALEM	CG + SJD	3.89 ± 2.12	4.15 ± 2.08	4.77 ± 0.40	261 ± 97	17.88 ± 5.90	80.61 ± 23.75
ALEM	MG + SJD	0.83 ± 0.62^a	0.46 ± 0.49^a	3.18 ± 0.45^a	564 ± 209^a	13.77 ± 3.00	38.51 ± 16.63^a
Rhein	CG + SJD	0.44 ± 0.18	0.71 ± 0.65	2.32 ± 0.40	3.07 ± 0.39	4388 ± 957	6136.71 ± 816.0
Rhein	MG + SJD	0.39 ± 0.14	0.82 ± 0.57	2.19 ± 0.21	2.41 ± 0.35^a	5206 ± 1703	8025.27 ± 1074.26^a
CHRY	CG + SJD	0.50 ± 0.19	1.02 ± 1.63	2.93 ± 0.57	411 ± 118	22.46 ± 7.78	39.12 ± 5.9
CHRY	MG + SJD	0.56 ± 0.27	0.96 ± 0.66	4.04 ± 0.63^a	271 ± 76^a	17.44 ± 3.71	58.90 ± 23.74
Curcumin	CG + SJD	0.44 ± 0.18	0.71 ± 0.27	4.60 ± 1.26	15957 ± 8161	0.93 ± 1.42	1.01 ± 0.86
Curcumin	MG + SJD	0.52 ± 0.08	0.69 ± 0.43	5.38 ± 0.71	25172 ± 11861	0.18 ± 0.04	0.56 ± 0.23
DEME	CG + SJD	0.89 ± 0.27	0.60 ± 0.49	4.90 ± 0.58	1518 ± 944	2.08 ± 0.37	10.62 ± 3.41
DEME	MG + SJD	0.50 ± 0.19	0.36 ± 0.45	5.83 ± 0.91	1064 ± 717	1.99 ± 0.91	8.60 ± 1.90
BISD	CG + SJD	0.50 ± 0.28	3.18 ± 0.30	4.44 ± 0.46	4117 ± 677	1.03 ± 0.27	3.97 ± 0.52
BISD	MG + SJD	0.61 ± 0.55	2.99 ± 0.14	3.93 ± 1.34	5159 ± 1829	0.83 ± 0.09	3.28 ± 0.47

^aP < 0.05 vs CG + SJD. ALEM: Aloe-emodin; CHRY: Chrysophanol; DEME: Demethoxycurcumin; BISD: Bisdemethoxycurcumin; Cmax: Maximum concentration; Tmax: Time of maximum concentration; MRT: Mean residence time.

Table 2 Component concentrations of Shengjiang decoction in the pancreas (ng/mL) (n = 6)

Group	Emodin	ALEM	Rhein	CHRY	Curcumin	DEME	BISD
CG + SJD	0.79 ± 0.38	0.29 ± 0.15	96.52 ± 31.35	0.54 ± 0.37	4.64 ± 2.74	0.22 ± 0.12	0.14 ± 0.03
MG + SJD	1.08 ± 0.30	0.26 ± 0.10	31.41 ± 13.27^a	0.58 ± 0.22	6.08 ± 2.77	0.20 ± 0.05	0.59 ± 0.22^a

^aP < 0.05 vs CG + SJD. ALEM: Aloe-emodin; CHRY: Chrysophanol; DEME: Demethoxycurcumin; BISD: Bisdemethoxycurcumin.

Citation: Zhu L, Li JY, Zhang YM, Kang HX, Chen H, Su H, Li J, Tang WF. Pharmacokinetics and pharmacodynamics of Shengjiang decoction in rats with acute pancreatitis for protecting against multiple organ injury. World J Gastroenterol 2017; 23(46): 8169-8181
URL: https://www.wjgnet.com/1007-9327/full/v23/i46/8169.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i46.8169