Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor

Table 1 Comparison of the number of Ki-67 positive cells and p-H2AX-positive cells in tumor sections from xenografted mice treated with the vehicle control, BEZ235, ⁹⁰Y-ITGA6B4, or ⁹⁰Y-ITGA6B4 + BEZ235

Group	Ki-67-positive cells		p-H2AX-positive cells
	Day 1	Day 3	Day 1	Day 3
Vehicle (control)	95.7 ± 11.4	87.0 ± 36.5	2.2 ± 0.8	2.3 ± 1.2
BEZ235	27.3 ± 19.4b	24.8 ± 8.4b	5.2 ± 3.8	4.0 ± 2.2
90Y-ITGA6B4	21.2 ± 11.8b	31.2 ± 18.8b	10.8 ± 2.8 be	12.7 ± 4.7 bd
90Y-ITGA6B4 + BEZ	13.0 ± 8.8b	7.3 ± 3.6abd	12.3 ± 5.5bc	19.3 ± 7.0 bd

Values are expressed as mean ± SD, n = 6.

^bP < 0.01 vs Vehicle,

^dP < 0.01 vs BEZ235;

^aP < 0.05 vs

⁹⁰Y-ITGA6B4,

^cP < 0.05 vs BEZ235,

^eP < 0.05 vs BEZ235.