Value of gamma-glutamyltranspeptidase-to-platelet ratio in diagnosis of hepatic fibrosis in patients with chronic hepatitis B

Table 1 Correlation of the GPR, APRI, and FIB-4 (mean ± SD) with the baseline characteristics of patients

Parameter		GPR	APRI	FIB-4
	Mean ± SD	r	r	r	P
TBIL (μmol/L)	22.70 ± 28.53	0.275	0.205	0.258	< 0.01
AST (IU/L)	81.71 ± 146.11	0.183	0.644	0.834	< 0.01
ALT (IU/L)	125.71 ± 246.43	0.113	0.547	0.764	< 0.01
GGT (IU/L)	225.21 ± 1008.88	0.779	0.222	0.235	< 0.01
PLT count (109/L)	160.82 ± 66.61	-0.285	-0.285	-0.26	< 0.01
GPR	0.73 ± 1.79	1.000	0.385	0.255	< 0.01
APRI	65.44 ± 140.77	0.385	1.000	0.847	< 0.01
FIB-4	417.93 ± 1367.85	0.255	0.847	1.000	< 0.01

TBIL: Total bilirubin; AST: Aspartate transaminase; ALT: Alanine transaminase; GGT: Gamma-glutamyltranspeptidase; PLT: Platelet; GPR: the gamma-glutamyltranspeptidase-to-platelet ratio; APRI: (AST)-to-platelet ratio index; FIB-4: Fibrosis-4.

Table 2 Correlation of the GPR, APRI, and FIB-4 (mean ± SD) with the liver function severity classification

Parameter	n	GPR	APRI	FIB-4
Liver function grade mild
Mild	244	0.50 ± 0.92	30.71 ± 76.73	68.39 ± 126.12
r		0.213	0.091	0.219
P		< 0.01	< 0.01	< 0.01
Moderate	57	1.57 ± 3.59	101.20 ± 202.09	511.23 ± 1234.61
r		0.11	0.16	0.191
P		< 0.01	< 0.01	< 0.01
Severe	80	0.84 ± 1.74	145.90 ± 192.51	1417.54 ± 2544.58
r		0.016	0.563	0.720
P		< 0.01	< 0.01	< 0.01

Table 3 Correlation of the GPR, APRI, and FIB-4 (mean ± SD) with the fibrosis grade

Parameter	n	GPR	APRI	FIB-4
Fibrosis grade
F1	122	0.54 ± 1.23	53.18 ± 134.37	331.04 ± 1152.78
r		0.077	0.089	0.077
P		< 0.01	< 0.01	< 0.01
F2	52	0.66 ± 2.02	47.55 ± 120.04	278.98 ± 1053.17
r		0.223	0.069	0.037
P		< 0.01	< 0.01	< 0.01
F3	61	0.60 ± 0.95	61.15 ± 152.26	406.94 ± 1580.52
r		0.278	0.226	0.183
P		< 0.01	< 0.01	< 0.01
F4	41	0.52 ± 0.85	49.43 ± 125.04	287.50 ± 1092.13
r		0.186	0.121	0.064
P		< 0.01	< 0.01	< 0.01

Table 4 GPR, APRI, and FIB-4 results relative to hepatic fibrosis stage (F1, F2, F3, and F4) in CHB patients

	Parameter	GPR	APRI	FIB-4	GPR + APRI (in parallel)	GPR + APRI (in series)	GPR + FIB-4 (in parallel)	GPR + FIB-4 (in series)
	AUC	0.723	0.581	0.612	-	-	-	-
	Cut-off	0.448	0.166	0.201	-	-	-	-
F1	Sensitivity	90.6%	88.8%	62.1%	88.8%	86.8%	80.2%	83.6%
	Specificity	54.2%	87.5%	66.3%	87.5%	90.2%	89%	87.9%
	AUC	0.741	0.706	0.711	-	-	-	-
	Cut-off	0.402	0.361	0.4	-	-	-	-
F2	Sensitivity	57.1%	75.8%	47.4%	72.7%	78.4%	65%	76.8%
	Specificity	89.5%	92.5%	89.3%	89.7%	96%	89%	96.6%
	AUC	0.826	0.73	0.751	-	-	-	-
	Cut-off	0.548	0.496	0.44	-	-	-	-
F3	Sensitivity	74.1%	70.6%	64.7%	81.3%	78.6%	70.3%	72.7%
	Specificity	91.8%	90.5%	88%	98.6%	97.4%	98.5%	98%
	AUC	0.833	0.799	0.778	-	-	-	-
	Cut-off	0.591	0.538	0.503	-	-	-	-
F4	Sensitivity	83.2%	74%	75.4%	80%	73.2%	78.8%	74.4%
	Specificity	96.5%	95.4%	94.5%	97.4%	97.9%	96.8%	97.7%

In parallel: Both parameters are met simultaneously; In series: One of two parameters is met.