Evaluation of the relationship between hepatocellular carcinoma location and transarterial chemoembolization efficacy

Table 1 Baseline characteristics (n = 115 patients, 127 nodules) n (%)

Characteristics	Values
Age
Median (range)	73 (49-92)
Sex
Male/Female	88 (76.5)/27 (23.5)
Etiology
Hepatitis B/C/B + C	13 (11.3)/85 (73.9)/2 (1.7)
Alcohol	10 (8.7)
NASH	2 (1.7)
PBC	3 (2.6)
Child-Pugh class
A/B	99 (86.1)/16 (13.9)
Location of target nodules
Anterior segment	39 (30.7)
Posterior segment	37 (29.1)
Medial segment	27 (21.3)
Lateral segment	24 (18.9)
Size of target nodules (mm)1	14.00 ± 10.30 (5.0-56.7)
Chemotherapeutic drug
Cisplatin/Epirubicin	87 (68.5)/40 (31.5)

¹Values are continuous data and are presented as the means ± SD. Numbers in parentheses are the ranges. NASH: Non-alcoholic stea-tohepatitis; PBC: Primary biliary cirrhosis.

Table 2 Evaluation of efficacy 6 mo after transcatheter arterial chemoembolization according to the modified response evaluation criteria in solid tumors criteria

	CR	PR	SD	PD	Total
All nodules	81	26	13	7	127
	(63.8)	(20.5)	(10.2)	(5.5)
Anterior segment	26	7	5	1	39
Posterior segment	22	8	3	4	37
Medial segment	14	8	4	1	27
Lateral segment	19	3	1	1	24
Patient with Child-Pugh grade A	56	17	10	3	86
	(65.1)	(19.8)	(11.6)	(3.5)
Anterior segment	19	5	5	1	30
Posterior segment	14	5	1	1	21
Medial segment	9	6	3	0	18
Lateral segment	14	1	1	1	17
Patients with Child-Pugh grade B	25	9	3	4	41
	(61.0)	(22.0)	(7.3)	(9.7)
Anterior segment	7	2	0	0	9
Posterior segment	8	3	2	3	16
Medial segment	5	2	1	1	9
Lateral segment	5	2	0	0	7

TACE: Transarterial chemoembolization; CR: Complete response; PR ± Partial response; SD: Stable disease; PD: Progressive disease.

Table 3 Hepatocellular carcinoma location coefficient in the complete response and non-complete response groups

	Non-CR group	CR group	P value
All lobes	0.63	0.8	< 0.001
Right lobe	0.68	0.81	< 0.05
Medial segment	0.49	0.8	< 0.01
Lateral segment	0.73	0.74	> 0.05
Patients with Child-Pugh grade A
All lobes	0.62	0.82	< 0.001
Right lobe	0.59	0.71	< 0.01
Medial segment	0.49	0.81	< 0.05
Lateral segment	0.65	0.67	> 0.05
Patients with Child-Pugh grade B
All lobes	0.73	0.75	> 0.05
Right lobe	0.84	0.79	> 0.05
Medial segment	0.43	0.69	> 0.05
Lateral segment	0.72	0.69	> 0.05

Values are expressed as the medians. HCC: Hepatocellular carcinoma; CR: Complete response.