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©The Author(s) 2017.
World J Gastroenterol. Sep 21, 2017; 23(35): 6429-6436
Published online Sep 21, 2017. doi: 10.3748/wjg.v23.i35.6429
Published online Sep 21, 2017. doi: 10.3748/wjg.v23.i35.6429
Table 1 Patient characteristics
Patient characteristics | |
Number of patients | 360 |
Age [mean ± SD (range), yr] | 71 ± 11.8 (17-95) |
Sex, male/female | 241/119 |
Disease (number of patients) | |
Bile duct cancer | 132 |
Pancreatic cancer | 86 |
Gallbladder cancer | 18 |
Metastasis | 14 |
Benign stricture | 110 |
Table 2 Overall diagnostic ability in all cases (n = 360)
Sample collection rate | |
Total number of biopsies | 820 |
Mean number of biopsies, ± SD (range) | 2.28 ± 0.91 (1-6) |
Overall results | |
Sensitivity | 69.6% |
Specificity | 100% |
PPV | 100% |
NPV | 59.1% |
Accuracy | 78.8% |
Table 3 Overall sensitivity for malignancy
Diagnosis | n | Sensitivity |
Bile duct cancer | 100/132 | 75.6% |
Pancreatic cancer | 55/86 | 64.0% |
Gallbladder cancer | 11/18 | 61.1% |
Metastasis | 8/14 | 57.1% |
Table 4 Sensitivity of biopsy forceps in bile duct cancer
n | Sensitivity | |
Total | 100/132 | 75.60% |
Site of stricture | ||
Perihilar bile duct | 46/67 | 68.7% |
Distal bile duct | 54/65 | 83.1% |
Middle | 21/22 | 95% |
Lower | 33/43 | 76.7% |
(Open space + | 22/26 | 84.6% |
(Open space − | 11/17 | 64.7% |
Table 5 Sensitivity of biopsy forceps in extrinsic neoplasms
n | Sensitivity | |
Pancreatic cancer | 55/86 | 64.0% |
Site of stricture | ||
Middle bile duct | 5/11 | 45.5% |
Lower bile duct | 50/75 | 66.7% |
Localization of tumor | ||
Head | 52/76 | 68.4% |
Body | 3/10 | 30.0% |
Gallbladder cancer | 11/18 | 61.1% |
Site of stricture | ||
Perihilar bile duct | 6/11 | 54.5% |
Distal bile duct | 5/7 | 71.4% |
Metastasis | 8/14 | 57.1% |
Site of stricture | ||
Perihilar bile duct | 4/6 | 66.7% |
Distal bile duct | 4/8 | 50.0% |
Table 6 Mean stricture lengths in extrinsic neoplasms
Positive (mm) | Negative (mm) | P value | |
Pancreatic cancer | 16.9 | 13.5 | < 0.05 |
Gallbladder cancer | 22 | 13.4 | < 0.05 |
Metastasis | 17.1 | 13.2 | NS |
Table 7 Characteristics of studies evaluating bile duct biopsies
- Citation: Yamamoto K, Tsuchiya T, Itoi T, Tsuji S, Tanaka R, Tonozuka R, Honjo M, Mukai S, Kamada K, Fujita M, Asai Y, Matsunami Y, Nagakawa Y, Yamaguchi H, Sofuni A. Evaluation of novel slim biopsy forceps for diagnosis of biliary strictures: Single-institutional study of consecutive 360 cases (with video). World J Gastroenterol 2017; 23(35): 6429-6436
- URL: https://www.wjgnet.com/1007-9327/full/v23/i35/6429.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i35.6429