Body mass index does not affect the survival of pancreatic cancer patients

Table 1 Demographics, comorbidity and stage of patients grouped according to body mass index

Characteristic	All patients	BMI category, kg/m2				P value
		< 18.5	18.5-22.9	23-27.4	≥ 27.5
Patients	1783	98 (5.5)	588 (33.0)	791 (44.4)	306 (17.2)
Sex						0.97
Male	1009 (56.6)	54 (3.0)	334 (18.7)	445 (25.0)	176 (9.9)
Female	774 (43.4)	44 (2.5)	254 (14.2)	346 (19.4)	130 (7.3)
Male/female ratio	1.30	1.23	1.31	1.29	1.35
BMI as kg/m2, mean ± SD	24.19 ± 3.53	17.60 ± 0.84	21.16 ± 1.23	25.07 ± 1.29	29.68 ± 2.11
Age at diagnosis in yr
Median	59.6	62.3	59.0	59.6	59.7
Range	22.5-84.6	28.7-81.7	22.5-80.2	30.7-84.6	26.0-84.6
Weight loss as % of usual adult weight
None	725 (40.7)	61 (3.4)	333 (18.7)	299 (16.8)	32 (1.8)
> 0, ≤ 10%	652 (36.6)	23 (1.3)	190 (10.7)	321 (18.0)	118 (6.6)
> 10%	406 (22.8)	14 (0.79)	65 (3.6)	171 (9.6)	156 (8.7)	< 0.0001
Any weight loss	1058 (59.3)	37 (2.1)	255 (14.3)	492 (27.6)	274 (15.4)	< 0.0001
Smoking						0.0003
Never	1243 (69.7)	72 (4.1)	408 (22.9)	568 (31.9)	195 (10.9)
Ever	527 (29.6)	22 (1.2)	176 (9.9)	220 (12.3)	109 (6.1)
Alcohol						0.42
Never	1377 (77.2)	76 (4.3)	465 (26.1)	614 (34.4)	222 (12.5)
Ever	398 (22.3)	21 (1.2)	121 (6.8)	174 (9.8)	82 (4.6)
Comorbidity
Diabetes	398 (22.3)	13 (0.7)	125 (7.0)	196 (11.0)	64 (3.6)	0.044
Coronary artery disease	247 (13.9)	8 (0.4)	46 (2.6)	166 (9.3)	27 (1.5)	< 0.0001
Hypertension	267 (15.0)	9 (0.5)	88 (4.9)	111 (6.2)	59 (3.3)	0.055
Previous history of cancer	14 (0.8)	1 (0.06)	6 (0.34)	6 (0.34)	1 (0.06)	0.72
Previous abdominal surgery	87 (4.9)	7 (0.39)	34 (1.9)	34 (1.9)	12 (0.67)	0.35
Stage group						0.89
Resectable	217 (12.2)	15 (0.84)	73 (4.1)	93 (5.2)	36 (2.0)
Unresectable locally advanced	316 (17.7)	17 (0.95)	108 (6.1)	143 (8.0)	48 (2.7)
Metastatic	1250 (70.1)	66 (3.7)	407 (22.8)	555 (31.1)	222 (12.5)

Data are n (%), unless otherwise indicated. BMI: Body mass index.

Table 2 Pancreatic cancer survival by usual adult body mass index category

Stage group	BMI category	n	Median overall survival, mo (95%CI)	HR	95%CI	P value	Ptrend value
Overall	< 18.5	98	8.0 (5.8-11.3)	1.12	0.83-1.52	0.45
	18.5-22.9	588	9.7 (8.7-11.1)	1.00	Ref.	Ref.
	23-27.4	791	9.5 (8.6-10.5)	0.99	0.87-1.14	0.92
	≥ 27.5	306	9.8 (7.6-11.2)	1.05	0.88-1.25	0.61	0.90
Resectable	< 18.5	15	11.1 (3.3-19.3)	1.92	0.74-5.01	0.18
	18.5-22.9	73	15.6 (10.1-21.3)	1.00	Ref.	Ref.
	23-27.4	93	16.7 (11.9-27.4)	0.92	0.59-1.44	0.71
	≥ 27.5	36	16.2 (4.5-23.7)	1.13	0.61-2.08	0.70	0.99
Unresectable locally advanced	< 18.5	17	7.0 (3.4-26.1)	0.83	0.38-1.84	0.65
	18.5-22.9	108	8.7 (7.3-11.7)	1.00	Ref.	Ref.
	23-27.4	143	8.6 (6.8-11.5)	1.03	0.73-1.45	0.86
	≥ 27.5	48	8.6 (4.9-15.6)	0.95	0.59-1.54	0.84	0.90
Metastatic	< 18.5	66	4.9 (2.8-8.0)	1.07	0.76-1.51	0.70
	18.5-22.9	407	5.5 (4.0-6.4)	1.00	Ref.	Ref.
	23-27.4	555	5.7 (3.7-6.8)	0.99	0.84-1.16	0.89
	≥ 27.5	222	5.6 (3.3-7.7)	1.02	0.84-1.27	0.76	0.88

BMI: Body mass index.