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©The Author(s) 2017.
World J Gastroenterol. Aug 28, 2017; 23(32): 5936-5944
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5936
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5936
Table 1 Univariate analysis of clinicopathological and histological parameters for lymph node metastasis
LNM | P value | ||
No (n = 221) | Yes (n = 31) | ||
Age (yr) | 61.81 ± 11.40 | 61.35 ± 10.63 | 0.8334 |
63.0 (31.0, 86.0) | 66.0 (38.0, 78.0) | ||
Sex | |||
Male | 115 (88.46) | 15 (11.54) | 0.7205 |
Female | 106 (86.89) | 16 (13.11) | |
Tumor location | |||
Ascending colon | 34 (89.48) | 4 (10.52) | 0.6018 |
Transverse colon | 12 (85.71) | 2 (14.29) | |
Descending colon | 6 (100.00) | 0 (0.00) | |
Sigmoid colon | 73 (91.25) | 7 (8.75) | |
Rectosigmoid colon | 14 (93.33) | 1 (6.67) | |
Rectum | 78 (82.98) | 16 (17.02) | |
Cecum | 3 (75.00) | 1 (25.00) | |
Vermiform appendix | 1 (100.00) | 0 (0.00) | |
Tumor size (cm) | 2.05 ± 1.67 | 2.07 ± 1.27 | 0.6902 |
1.8 (0.2, 6.5) | 2.0 (0.4, 6.5) | ||
Tumor type | |||
Pedunculated type | 84 (93.33) | 6 (6.67) | 0.0424 |
Sessile type | 137 (84.57) | 25 (15.43) | |
Depth of submucosal invasion | |||
by JSCCR (μm) | 2473.94 ± 2003.78 | 3777.42 ± 2167.10 | 0.0002 |
2200.0 (0.0, 13500.0) | 3500.0 (1050.0, 12000.0) | ||
< 1000 | 46 (100.00) | 0 (0.00) | 0.0021 |
≥ 1000 | 175 (84.95) | 31 (15.05) | |
by Kitajima (μm) | 1944.3 ± 1885.18 | 3380.65 ± 2390.28 | 0.0002 |
1900.0 (0.0, 13500.0) | 3000.0 (500.0, 12000.0) | ||
< 1000 | 76 (95.00) | 4 (5.00) | 0.0218 |
≥ 1000 | 145 (94.30) | 27 (15.70) | |
by Ueno (μm) | 2671 ± 1898.39 | 3908.06 ± 2147.17 | 0.0002 |
2300.0 (50.0, 13500.0) | 3500.0 (1050.0, 12000.0) | ||
< 1000 | 34 (100.00) | 0 (0.00) | 0.0113 |
≥ 1000 | 187 (85.78) | 31 (14.22) | |
Width of submucosal invasion (μm) | 5831.45 ± 4724.02 | 9261.29 ± 4692.03 | < 0.0001 |
5000.0 (50.0, 31000.0) | 8000.0 (1900.0, 21000.0) | ||
< 4000 μm | 87 (96.67) | 3 (3.33) | 0.0010 |
≥ 4000 μm | 134 (82.72) | 28 (17.28) | |
Depth multiplied by width | |||
by JSCCR (mm2) | 20.22 ± 35.07 | 38.91 ± 36.50 | < 0.0001 |
11.6 (0.0, 303.8) | 26.6 (2.0, 163.8) | ||
< 6.5 | 84 (98.82) | 1 (1.18) | < 0.0001 |
≥ 6.5 | 137 (82.04) | 30 (17.96) | |
by Kitajima (mm2) | 16.79 ± 34.52 | 36.42 ± 37.97 | < 0.0001 |
8.8 (0.0, 303.8) | 23.1 (2.0, 163.8) | ||
< 6.5 | 100 (95.24) | 5 (4.76) | 0.0017 |
≥ 6.5 | 121 (82.31) | 26 (17.69) | |
by Ueno (mm2) | 20.91 ± 34.82 | 40.12 ± 36.52 | < 0.0001 |
12.8 (0.0, 303.8) | 26.6 (2.0, 163.8) | ||
< 6.5 | 76 (98.70) | 1 (1.30) | 0.0001 |
≥ 6.5 | 145 (82.86) | 30 (17.14) | |
Tumor differentiation | |||
Well and moderately | 211 (87.92) | 29 (12.08) | 0.6470 |
Poorly | 10 (83.33) | 2 (16.67) | |
Lymphatic invasion | |||
No | 190 (95.96) | 8 (4.04) | < 0.0001 |
Yes | 31 (57.41) | 23 (42.59) | |
Venous invasion | |||
No | 215 (87.76) | 30 (12.24) | 1.0000 |
Yes | 6 (85.71) | 1 (14.29) | |
Perineural invasion | |||
No | 219 (87.60) | 31 (12.40) | 1.0000 |
Yes | 2 (100) | 0 (0.00) | |
Inflammation | |||
No | 100 (87.72) | 14 (12.28) | 1.0000 |
Yes | 121 (87.68) | 17 (12.32) | |
Desmoplasia | |||
No | 106 (92.17) | 9 (7.83) | 0.0550 |
Yes | 115 (83.94) | 22 (16.06) | |
Tumor budding | |||
Ueno | |||
Grade 0, 1 | 158 (95.18) | 8 (4.82) | < 0.0001 |
Grade 2, 3 | 63 (73.26) | 23 (26.74) | |
Present or absent | |||
No | 119 (100) | 0 (0.00) | < 0.0001 |
Yes | 102 (76.69) | 31 (23.31) | |
PDCs | |||
No | 110 (100.00) | 0 (0.00) | < 0.0001 |
Yes | 111 (78.17) | 31 (21.83) |
Table 2 Predictive powers of histopathological factors for lymph node metastasis
Sensitivity | Specificity | Accuracy | Positive P value | Negative P value | |
Depth of submucosal invasion | |||||
by JSCCR | 100.00% | 20.81% | 30.56% | 15.05% | 100.00% |
by Kitajima | 87.10% | 34.39% | 40.87% | 15.70% | 95.00% |
by Ueno | 100.00% | 15.38% | 25.79% | 14.22% | 100.00% |
Width of submucosal invasion | 90.32% | 39.37% | 45.63% | 17.28% | 96.67% |
Depth multiplied by width | |||||
by JSCCR | 96.77% | 38.01% | 45.24% | 17.96% | 98.82% |
by Kitajima | 83.87% | 45.25% | 50.00% | 17.69% | 95.24% |
by Ueno | 96.77% | 34.39% | 42.06% | 17.14% | 98.70% |
Lymphatic invasion | 74.19% | 85.97% | 84.52% | 42.59% | 95.96% |
Tumor budding | |||||
by Ueno | 74.19% | 71.49% | 71.83% | 26.74% | 95.18% |
Present or absent | 100.00% | 53.84% | 59.52% | 23.31% | 100.00% |
PDCs | 100.00% | 49.77% | 55.95% | 21.83% | 100.00% |
Table 3 Comparison of histopathological factors for predicting of lymph node metastasis by multivariate analysis
Model | AUC | SE | 95%CI | Difference AUC | 95%CI | P value |
Crude (unadjusted) | 0.640 | 0.046 | (0.549, 0.730) | |||
JSCCR (depth) | 0.666 | 0.041 | (0.585, 0.747) | 0.026 | (0.009, 0.043) | 0.0022 |
Kitajima (depth) | 0.650 | 0.044 | (0.565, 0.736) | 0.011 | (-0.022, 0.043) | 0.5103 |
Ueno (depth) | 0.664 | 0.042 | (0.582, 0.746) | 0.024 | (0.009, 0.040) | 0.0024 |
Width | 0.692 | 0.040 | (0.613, 0.771) | 0.053 | (-0.007, 0.112) | 0.0829 |
JSCCR (depth × width) | 0.703 | 0.038 | (0.629, 0.776) | 0.063 | (0.024, 0.103) | 0.0017 |
Kitajima (depth × width) | 0.681 | 0.042 | (0.599, 0.763) | 0.042 | (-0.002, 0.085) | 0.0612 |
Ueno (depth × width) | 0.699 | 0.038 | (0.624, 0.775) | 0.060 | (0.020, 0.099) | 0.0030 |
Budding (ueno) | 0.768 | 0.044 | (0.682, 0.853) | 0.128 | (0.043, 0.214) | 0.0033 |
Lymphatic invasion | 0.843 | 0.041 | (0.763, 0.924) | 0.204 | (0.114, 0.294) | < 0.0001 |
Budding present itself | 0.830 | 0.0277 | (0.776, 0.884) | 0.190 | (0.106, 0.274) | < 0.0001 |
PDCs | 0.811 | 0.0296 | (0.753, 0.870) | 0.172 | (0.087, 0.256) | < 0.0001 |
- Citation: Yim K, Won DD, Lee IK, Oh ST, Jung ES, Lee SH. Novel predictors for lymph node metastasis in submucosal invasive colorectal carcinoma. World J Gastroenterol 2017; 23(32): 5936-5944
- URL: https://www.wjgnet.com/1007-9327/full/v23/i32/5936.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i32.5936