Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis

doi:10.3748/wjg.v23.i32.5904

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World Journal of Gastroenterology

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World J Gastroenterol. Aug 28, 2017; 23(32): 5904-5912
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5904

Table 1 Impact of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten on liver function in rat liver fibrosis induced by CCl₄ in prevention groups at different time points

Group	ALT (U/L)	AST (U/L)	ALB (g/L)	TBIL (μmol/L)	DBIL (μmol/L)
Pre 1 wk
Control	58.09 ± 6.54	147.23 ± 10.25	28.95 ± 2.14	2.15 ± 0.54	1.12 ± 0.32
CCl₄	414.45 ± 29.37	339.12 ± 45.37	27.20 ± 2.35	2.12 ± 0.38	1.70 ± 0.21
Ad-GFP	426.24 ± 30.76	289.37 ± 20.76	27.92 ± 3.12	2.13 ± 0.31	1.56 ± 0.12
Ad-PTEN	404.23 ± 26.78	283.76 ± 23.45^a	29.12 ± 4.25	1.98 ± 0.34	1.42 ± 0.31
Ad-G129E	409.98 ± 43.24	289.76 ± 35.43^a	28.82 ± 3.23	2.00 ± 0.34	1.50 ± 0.21
PTEN shRNA	2970.11 ± 267.34^b	1690.25 ± 200.34^b	27.10 ± 3.23	4.03 ± 0.78^b	2.67 ± 0.56^b
Pre 3 wk
Control	60.71 ± 5.34	150.54 ± 12.34	27.65 ± 3.28	2.34 ± 0.23	1.28 ± 0.77
CCl₄	532.21 ± 34.02	804.12 ± 67.34	25.31 ± 4.32	17.31 ± 1.21	7.78 ± 2.01
Ad-GFP	589.34 ± 26.45	787.45 ± 43.21	26.70 ± 3.15	15.04 ± 2.12	7.34 ± 1.29
Ad-PTEN	422.37 ± 34.23^a	478.43 ± 50.34^a	27.31 ± 2.43	5.78 ± 1.01^a	3.24 ± 0.78^a
Ad-G129E	506.45 ± 57.32	526.43 ± 32.98^a	26.59 ± 1.37	10.54 ± 2.76^a	6.21 ± 2.37
PTEN shRNA	3440.32 ± 342.32^b	3090.39 ± 228.23^b	24.41 ± 2.34^b	28.37 ± 4.78^b	14.56 ± 2.42^b
Pre 5 wk
Control	59.22 ± 7.34	145.38 ± 11.32	28.37 ± 2.56	2.34 ± 0.78	1.43 ± 0.22
CCl₄	672.34 ± 17.37	817.56 ± 46.32	26.70 ± 3.02	15.23 ± 2.78	7.65 ± 1.22
Ad-GFP	597.45 ± 33.21	753.24 ± 32.12	26.30 ± 1.76	16.30 ± 3.56	8.72 ± 2.11
Ad-PTEN	456.43 ± 32.12^a	566.76 ± 53.21^a	28.54 ± 2.12^a	9.31 ± 2.12^a	4.50 ± 0.89^a
Ad-G129E	492.37 ± 40.65^a	705.43 ± 63.21^a	27.21 ± 1.35	10.56 ± 1.23^a	5.61 ± 1.23^a
PTEN shRNA	2060.21 ± 325.34^b	2490.34 ± 532.12^b	24.23 ± 1.23^b	17.31 ± 2.67^b	9.45 ± 2.12^b
Pre 7 wk
Control	60.21 ± 3.19	152.12 ± 15.34	28.34 ± 1.15	2.38 ± 0.59	1.48 ± 0.26
CCl₄	605.23 ± 85.37	1110.32 ± 215.32	22.76 ± 3.21	15.26 ± 1.23	8.65 ± 0.32
Ad-GFP	623.45 ± 56.34	1134.23 ± 121.24	23.43 ± 1.21	14.87 ± 1.02	9.34 ± 0.98
Ad-PTEN	456.45 ± 32.12^a	183.23 ± 34.23^a	26.73 ± 2.23^a	4.32 ± 0.97	2.62 ± 0.42
Ad-G129E	545.87 ± 43.21^a	694.32 ± 25.34^a	25.63 ± 1.23^a	4.56 ± 0.32	2.54 ± 0.23
PTEN shRNA	1825.23 ± 28.23^b	1878.45 ± 56.87^b	21.90 ± 3.23^b	17.23 ± 3.56^b	9.08 ± 1.32^b

Data are presented as mean ± SD for n = 3.

^aP < 0.01 vs CCl₄, Ad-GFP;

^bP < 0.05 vs CCl₄, Ad-GFP, Ad-PTEN. ALB: Albumin; ALT: Alanine transaminase; AST: Aspartate transaminase; DBIL: Direct bilirubin; PTEN: Phosphatase and tension homologue deleted on chromosome ten; TBIL: Total bilirubin.

Table 2 Impact of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten on liver function in rat liver fibrosis induced by CCl₄ in treatment groups at different time points

Group	ALT (U/L)	AST (U/L)	ALB (g/L)	TBIL (μmol/L)	DBIL (μmol/L)
Tre 1 wk
Control	57.78 ± 8.23	146.78 ± 12.23	27.99 ± 1.18	2.49 ± 0.55	1.65 ± 0.36
CCl₄	684.32 ± 78.34	840.32 ± 32.25	25.26 ± 3.25	15.45 ± 3.23	6.56 ± 1.12
Ad-GFP	645.65 ± 34.26	832.12 ± 40.32	24.54 ± 1.21	14.31 ± 1.21	7.21 ± 2.12
Ad-PTEN	384.98 ± 36.23^b	398.43 ± 43.23^b	27.60 ± 2.34^b	11.21 ± 1.21^b	5.32 ± 1.46^b
Ad-G129E	495.34 ± 45.12^b	546.32 ± 32.12^b	26.12 ± 2.43	13.23 ± 2.12	7.86 ± 1.23^b
PTEN shRNA	2030.31 ± 112.34^a	1730.54 ± 87.34^a	24.12 ± 2.34^a	34.21 ± 5.34^a	17.23 ± 2.12^a
Tre 2 wk
Control	57.46 ± 3.58	142.34 ± 10.24	29.15 ± 3.21	2.68 ± 0.74	1.55 ± 0.46
CCl₄	712.34 ± 34.54	843.23 ± 54.32	26.32 ± 1.34	14.32 ± 5.32	8.32 ± 2.12
Ad-GFP	697.45 ± 45.76	876.34 ± 33.32	25.79 ± 2.32	13.34 ± 2.13	7.86 ± 1.23
Ad-PTEN	338.12 ± 12.34^b	407.34 ± 32.12^b	27.56 ± 3.23^b	6.56 ± 1.21^b	3.72 ± 0.78^b
Ad-G129E	364.32 ± 34.56^b	408.67 ± 23.78^b	27.21 ± 1.22^b	10.32 ± 1.21^b	5.34 ± 1.09^b
PTEN shRNA	2040.21 ± 126.32^a	1860.32 ± 210.32^a	25.60 ± 3.12^a	27.12 ± 4.21^a	14.78 ± 2.12^a
Tre 3 wk
Control	58.54 ± 6.58	148.45 ± 13.27	29.12 ± 3.15	2.12 ± 0.21	1.48 ± 0.24
CCl₄	1892.32 ± 113.12	2018.32 ± 123.45	22.14 ± 1.23	8.18 ± 1.10	5.21 ± 0.65
Ad-GFP	1746.32 ± 98.23	1879.23 ± 119.34	23.10 ± 2.13	9.12 ± 1.23	5.72 ± 0.54
Ad-PTEN	524.35 ± 34.12^b	690.35 ± 54.23^b	27.30 ± 3.21^b	6.45 ± 0.32^b	4.12 ± 0.54^b
Ad-G129E	576.23 ± 43.21^b	820.43 ± 67.32^b	25.20 ± 1.21^b	8.12 ± 0.87^b	4.89 ± 0.81^b
PTEN shRNA	1937.56 ± 32.21^a	2390.32 ± 112.23^a	21.34 ± 2.34^a	10.76 ± 1.23^a	6.10 ± 0.54^a
Tre 4 wk
Control	62.31 ± 8.12	155.37 ± 13.27	29.91 ± 3.12	2.49 ± 0.32	1.65 ± 0.21
CCl₄	594.39 ± 32.18	1110.32 ± 89.34	23.45 ± 2.12	17.32 ± 2.32	9.28 ± 1.23
Ad-GFP	576.45 ± 23.43	886.43 ± 45.67	22.79 ± 1.21	13.45 ± 2.45	7.12 ± 1.34
Ad-PTEN	490.32 ± 32.23^b	528.34 ± 32.12^b	25.31 ± 3.21^b	7.34 ± 1.21^b	4.65 ± 0.98^b
Ad-G129E	530.23 ± 22.56^b	628.43 ± 45.34^b	25.12 ± 1.23^b	10.54 ± 2.32^b	6.54 ± 1.21^b
PTEN shRNA	1148.32 ± 54.32^a	1270.34 ± 121.28^a	20.37 ± 3.12^a	26.32 ± 3.56^a	14.56 ± 2.13^a

Data are presented as mean ± SD for n = 3.

^aP < 0.05 vs CCl₄, Ad-GFP, Ad-PTEN;

^bP < 0.01 vs CCl₄, Ad-GFP. ALB: Albumin; ALT: Alanine transaminase; AST: Aspartate transaminase; DBIL: Direct bilirubin; PTEN: Phosphatase and tension homologue deleted on chromosome ten; TBIL: Total bilirubin.

Citation: Xie SR, An JY, Zheng LB, Huo XX, Guo J, Shih D, Zhang XL. Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis. World J Gastroenterol 2017; 23(32): 5904-5912
URL: https://www.wjgnet.com/1007-9327/full/v23/i32/5904.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i32.5904