Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn's disease

Table 1 Demographic and clinical characteristics of patients undergoing surgery for stricturing Crohn’s disease with and without incidental finding of colorectal cancer n (%)

	Stricturing CD	Stricturing CD and incidental cancer	P value
Patients	478	6
Age (yr)	35.2 (11-82)	43 (27-66)	NS
Sex			NS
Female	214 (44.8)	2 (33.3)
Male	264 (55.2)	4 (66.6)
Body Mass Index (kg/m2)	21.4 ± 3.9	22.4 ± 4.4	NS
Age at CD diagnosis (yr)	26 (6-82)	26.5 (11-44)	NS
Smoking (yes)	227 (47.5)	1 (16.6)	NS
Medical therapy			NS
AZA/6-MP	105 (22)	1 (16.6)
Corticosteroids	128 (26.8)	0
Anti-TNF antibody	5 (1)	0
CD related surgery	1 (1-25)	2 (1-3)	NS

CD: Crohn’s disease; AZA/6-MP: Azathioprin/6-mercaptopurin; TNF: Tumor necrosis factor.

Table 2 Characteristics of patients with incidental adenocarcinoma after surgery for stricturing Crohn’s disease

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6
Age	66	27	48	36	38	60
Sex	Female	Female	Male	Male	Male	Male
BMI	17.6	19.5	20.0	21.7	28.0	27.7
Age at CD diagnosis	30	11	18	23	31	44
Smoking	Yes	No	No	No	No	No
Azathioprine/6-Mercaptopurine	No	Yes	No	No	No	No
Corticosteroids	No	No	No	No	No	No
Anti TNF-Antibodies	No	No	No	No	No	No
Previous CD Surgery	3	1	3	2	1	2
Indication	Elective	Acute	Elective	Elective	Acute	Elective
Resection typ	Simple	Simple	Complex	Simple	Complex	Complex
Operative Time (min)	130	100	90	199	70	135
Location of Stricture	Rectum	Descending Colon	Rectum	Rectum	Ileum	Rectum
UICC Staging	IIIC	IIIB	IIA	I	IV	I

BMI: Body mass index; CD: Crohn’s disease; TNF: Tumor necrosis factor; UICC: Union for International Cancer Control.

Table 3 Studies focusing on incidental finding of adenocarcinoma in patients undergoing surgery for Crohn’s disease

	Patients (n) incidental adenocarcinoma (%)	Risk factors
Maykel et al[7] (2006)	222 (2.3)	Age, duration and extent of disease
Yamazaki et al[9] (1991)	132 (6.8)	Age, duration of disease
Fumery et al[10] (2015)	248 (0.8)	No active disease at surgery
Kristo et al (present study)	484 (1.2)	-