Copyright
©The Author(s) 2017.
World J Gastroenterol. Jan 21, 2017; 23(3): 447-454
Published online Jan 21, 2017. doi: 10.3748/wjg.v23.i3.447
Published online Jan 21, 2017. doi: 10.3748/wjg.v23.i3.447
Table 1 Genotypes of the investigated IL23R single nucleotide polymorphisms in Hungarian population n (%)
SNP | Genotype | UC | Allele | UC |
rs11209026 | GG | 109 (95.6) | G | 223 (97.8) |
AG | 5 (4.4) | A | 5 (2.2) | |
AA | 0 (0.0) | |||
total | 114 | |||
RAF | 0.0219 | |||
rs10889677 | CC | 51 (45.5) | C | 155 (69.2) |
AC | 53 (47.3) | A | 69 (30.8) | |
AA | 8 (7.1) | |||
total | 112 | |||
RAF | 0.308 | |||
rs1004819 | GG | 52 (40.3) | G | 172 (66.7) |
AG | 68 (52.7) | A | 86 (33.3) | |
AA | 9 (7.0) | |||
total | 129 | |||
RAF | 0.333 | |||
rs2201841 | TT | 58 (45.0) | T | 176 (68.2) |
CT | 60 (46.5) | C | 82 (31.8) | |
CC | 11 (8.5) | |||
Total | 129 | |||
RAF | 0.317 | |||
rs7517847 | TT | 40 (35.7) | T | 136 (60.7) |
GT | 56 (50.0) | G | 88 (39.3) | |
GG | 16 (14.3) | |||
Total | 112 | |||
RAF | 0.392 | |||
rs10489629 | GG | 44 (34.6) | G | 155 (61.0) |
AG | 67 (52.8) | A | 99 (39.0) | |
AA | 16 (12.6) | |||
Total | 127 | |||
RAF | 0.389 | |||
rs7530511 | CC | 94 (73.4) | C | 220 (85.9) |
TC | 32 (25.0) | T | 36 (14.1) | |
TT | 2 (1.6) | |||
Total | 128 | |||
RAF | 0.140 |
Table 2 IL23R single nucleotide polymorphisms with statistically significant influence on the clinical picture of ulcerative colitis
SNP | Wt vs Hz | Wt vs Ho | Wt vs Hz + Ho | Wt + Hz vs Ho | Total distribution |
rs2201841 | |||||
Montreal-classification | 0.0429a | 0.2270 | 0.1921 | 0.0217a | 0.0084a |
Iron deficiency | 0.1892 | 0.1108 | 0.7476 | 0.0388a | 0.0299a |
Need for operation | 0.0348a | 1.0000 | 0.0766 | 0.6017 | 0.0564 |
rs7517847 | |||||
Bowel movements | 0.0050a | 0.8183 | 0.0634 | 0.2979 | 0.0078a |
rs10489629 | |||||
Montreal classification | 0.1017 | 0.3906 | 0.4445 | 0.1170 | 0.0405a |
Weight loss | 0.0652 | 0.0457a | 0.0169a | 0.1191 | 0.0350a |
rs10889677 | |||||
Azathioprine | 0.0116a | 0.3407 | 0.0136a | 0.6113 | 0.0285a |
Need for operation | 0.0347a | 0.8491 | 0.0746 | 0.6153 | 0.0595 |
- Citation: Fischer S, Kövesdi E, Magyari L, Csöngei V, Hadzsiev K, Melegh B, Hegyi P, Sarlós P. IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis. World J Gastroenterol 2017; 23(3): 447-454
- URL: https://www.wjgnet.com/1007-9327/full/v23/i3/447.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i3.447