Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population

doi:10.3748/wjg.v23.i28.5179

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 23, Issue 28

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7386)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-4) series.

Item

Count

PDF

388

WORD

265

HTML

3348

Tables (1-4)

208

Sum=4209

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

987

Download

2190

Sum=3177

Jul 28, 2017 (publication date) through Dec 28, 2024

Times Cited of This Article

Times Cited (18)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Gastroenterol. Jul 28, 2017; 23(28): 5179-5186
Published online Jul 28, 2017. doi: 10.3748/wjg.v23.i28.5179

Table 1 Characteristics of the study population

Variable	Cases			P value
Variable	Colonic polyps, n = 144	Colon cancer, n = 96	Ulcerative colitis, n = 44	P value
Sex, n (%)				0.9631¹
Males	70 (48.6)	48 (50.0)	21(47.7)
Female	74 (51.4)	48 (50.0)	23 (52.3)
Age in years, mean ± SD	56.1 ± 10.7	58.8 ± 14.1	55.0 ± 12.4	0.1401²

¹P value was calculated by the χ² test;

²P value was calculated by the ANOVA test.

Table 2 Association between the selected single nucleotide polymorphisms and risks of colon cancer, polyp and ulcerative colitis

Variable (MJ/MI)	Cases/controls	Genetic model	P for Fisher's test
rs4809957 A/G	Cancer/1KGeno	AG + GG vs AA	2.20E-16
		G vs A	2.20E-16
		GG vs AG + AA	2.20E-16
	Polyp/1KGeno	AG + GG vs AA	2.20E-16
		G vs A	2.20E-16
		GG vs AG + AA	2.20E-16
	UC/1KGeno	AG + GG vs AA	2.20E-16
		G vs A	2.20E-16
		GG vs AG + AA	9.37E-09
	Cancer/Polyp	AG + GG vs AA	0.7998
		G vs A	0.8036
		GG vs AG + AA	1.0000
	Cancer/UC	AG + GG vs AA	0.4362
		G vs A	0.4424
		GG vs AG + AA	1.0000
	Polyp/UC	AG + GG vs AA	0.3011
		G vs A	0.3096
		GG vs AG + AA	1.0000
rs6068816 C/T	Cancer/1KGeno	CT + TT vs CC	2.20E-16
		T vs C	2.20E-16
		TT vs CT + CC	2.20E-16
	Polyp/1KGeno	CT + TT vs CC	2.20E-16
		T vs C	2.20E-16
		TT vs CT + CC	2.20E-16
	UC/1KGeno	CT + TT vs CC	2.29E-09
		T vs C	2.20E-16
		TT vs CT + CC	2.20E-16
	Cancer/Polyp	CT + TT vs CC	1.0000
		T vs C	0.4635
		TT vs CT + CC	0.4546
	Cancer/UC	CT + TT vs CC	1.0000
		T vs C	0.2786
		TT vs CT + CC	0.2658
	Polyp/UC	CT + TT vs CC	1.0000
		T vs C	0.06703
		TT vs CT + CC	0.06164
rs6091822 G/T	Cancer/1KGeno	GT + TT vs GG	2.20E-16
		T vs G	1.06E-08
		TT vs GT + GG	0.000472
	Polyp/1KGeno	GT + TT vs GG	2.20E-16
		T vs G	4.06E-12
		TT vs GT + GG	0.001364
	UC/1KGeno	GT + TT vs GG	1.32E-13
		T vs G	2.40E-05
		TT vs GT + GG	0.2411
	Cancer/Polyp	GT + TT vs GG	1.0000
		T vs G	0.9258
		TT vs GT + GG	0.5180
	Cancer/UC	GT + TT vs GG	1.0000
		T vs G	0.8971
		TT vs GT + GG	0.3094
	Polyp/UC	GT + TT vs GG	1.0000
		T vs G	1.0000
		TT vs GT + GG	0.5456
rs8124792 G/A	Cancer/1KGeno	GA + AA vs GG	2.20E-16
		A vs G	2.20E-16
		AA vs GA + GG	0.000758
	Polyp/1KGeno	GA + AA vs GG	2.20E-16
		A vs G	2.20E-16
		AA vs GA + GG	4.75E-05
	UC/1KGeno	GA + AA vs GG	4.90E-09
		A vs G	2.91E-09
		AA vs GA + GG	0.06359
	Cancer/Polyp	GA + AA vs GG	1.0000
		A vs G	1.0000
		AA vs GA + GG	1.0000
	Cancer/UC	GA + AA vs GG	1.0000
		A vs G	1.0000
		AA vs GA + GG	1.0000
	Polyp/UC	GA + AA vs GG	1.0000
		A vs G	1.0000
		AA vs GA + GG	1.0000

1KGeno: Control from 1000 Genomes Project; Cancer: Colon cancer cohort; MI: Minor allele (i.e., less common in controls); MJ: Major allele (i.e., more common in controls); Polyp: Colonic polyp cohort; UC: Ulcerative colitis cohort.

Table 3 Associations between the selected single nucleotide polymorphisms and colon cancer, colonic polyp and ulcerative colitis, and odds ratio for the association of each polymorphism with these diseases

Variable (MJ/Mi^a)	MAF^a	HWE P^a	Cases/controls	Genetic model	P for χ² test	Odds ratio for MI/MJ	95%CI
rs4809957 A/G	0.393	0.476	Cancer/1KGeno	G vs A	2.50E-48	0.021	0.009	0.048
			Polyp/1KGeno	G vs A	1.64E-64	0.026	0.014	0.048
			UC/1KGeno	G vs A	1.57E-26	0.008	0.001	0.055
rs6068816 C/T	0.388	0.434	Cancer/1KGeno	T vs C	8.00E-47	32.086	16.238	63.403
			Polyp/1KGeno	T vs C	8.72E-68	48.918	24.888	96.150
			UC/1KGeno	T vs C	3.83E-22	18.260	8.350	39.932
rs6091822 G/T	0.284	0.208	Cancer/1KGeno	T vs G	3.72E-09	2.524	1.844	3.457
			Polyp/1KGeno	T vs G	1.37E-12	2.596	1.984	3.395
			UC/1KGeno	T vs G	0.00001	2.645	1.696	4.125
rs8124792 G/A	0.281	0.616	Cancer/1KGeno	G vs A	1.26E-13	0.083	0.036	0.188
			Polyp/1KGeno	G vs A	2.93E-18	0.086	0.044	0.170
			UC/1KGeno	G vs A	2.58E-07	0.062	0.015	0.256

^aMAF and HWE were calculated among controls only. 1KGeno: Control from 1000 Genomes Project; Cancer: Colon cancer cohort; MI: Minor allele (i.e., less common in controls); MJ: Major allele (i.e., more common in controls); Polyp: Colonic polyp cohort; UC: Ulcerative colitis cohort.

Table 4 Frequencies and distributions of rs6091822 G/T and odds ratio for the association

Variable (MJ/Mi)		Cases			Controls			P for χ² test	Odds ratio, GT + TT vs GG	95%CI
		GG	GT	TT	GG	GT	TT
rs6091822 G/T	Cancer/1KGeno	0	142	2	262	198	44	1.30E-20	0.010	0.001	0.069
	Polyp/1KGeno	0	96	0				9.75E-29	0.006	0.001	0.046
	UC/1KGeno	0	42	1				1.53E-10	0.021	0.003	0.154

MJ: Major allele (i.e., more common in controls); MI: Minor allele (i.e., less common in controls).

Citation: Chen XQ, Mao JY, Li WB, Li J, Yang H, Qian JM, Li JN. Association between CYP24A1 polymorphisms and the risk of colonic polyps and colon cancer in a Chinese population. World J Gastroenterol 2017; 23(28): 5179-5186
URL: https://www.wjgnet.com/1007-9327/full/v23/i28/5179.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i28.5179