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©The Author(s) 2017.
World J Gastroenterol. Jul 21, 2017; 23(27): 4978-4985
Published online Jul 21, 2017. doi: 10.3748/wjg.v23.i27.4978
Published online Jul 21, 2017. doi: 10.3748/wjg.v23.i27.4978
Table 1 Patient characteristics
Characteristic | n = 223 |
Age in yr | 62.3 ± 9.9 |
Sex, n | |
Male | 159 |
Female | 64 |
BMI in kg/m2 | 23.0 ± 3.4 |
Comorbidities, n | |
Diabetes mellitus | 15 |
Hypertension | 72 |
Preoperative serum albumin in g/L | 38.3 ± 3.2 |
Preoperative hemoglobin in g/L | 123.4 ± 24.9 |
Preoperative CRP in g/L | 6.6 ± 10.3 |
CA 19-9 in ng/mL | |
≥ 37 | 43 |
< 37 | 180 |
CEA in ng/mL | |
≥ 5 | 26 |
< 5 | 197 |
Lymphocyte count as × 109/L | |
≥ 3 | 9 |
< 3 | 214 |
CRP on POD 3 in mg/L | 99.7 ± 60.9 |
ALB on POD 1 in g/L | 32.7 ± 3.6 |
ASA ≥ 3, n | 122 |
Clinical stage I/II/III/IV, n | 67/44/103/9 |
Mode of surgical approach, n | |
Laparoscopic | 18 |
Open | 205 |
Type of resection, n | |
Distal gastrectomy | 82 |
Proximal gastrectomy | 24 |
Total gastrectomy | 117 |
Degree of lymph node dissection ≥ 2, n | 180 |
Operation time in min | 239.1 ± 66.9 |
Blood loss in mL | 228.6 ± 146.2 |
Postoperative complications as Clavien-Dindo grade, n | |
I and II | 40 |
≥ III | 22 |
Postoperative stay in d | 15.8 ± 8.6 |
Table 2 Univariate analysis of risk factors associated with postoperative complications
Characteristic | OR | 95%CI | P value |
Age ≥ 75 yr | 1.330 | 0.476-3.715 | 0.586 |
Sex | 0.642 | 0.342-1.202 | 0.166 |
BMI of < 18.5 kg/m2 | 0.277 | 0.034-2.232 | 0.228 |
Comorbidities | |||
Diabetes mellitus | 3.259 | 1.128-9.414 | 0.029 |
Hypertension | 0.728 | 0.382-1.389 | 0.336 |
Preoperative serum albumin of < 35 g/L | 1.048 | 1.018-1.109 | 0.015 |
Preoperative hemoglobin of < 120 g/L | 1.487 | 0.817-2.705 | 0.194 |
Preoperative CRP of ≥ 10 g/L | 1.336 | 0.512-3.486 | 0.553 |
CA 19-9 of ≥ 37 ng/mL | 1.328 | 0.647-2.723 | 0.439 |
CEA of ≥ 5 ng/mL | 1.177 | 0.483-2.865 | 0.720 |
Lymphocyte count of ≥ 3 × 109/L | 0.314 | 0.038-2.560 | 0.279 |
CRP on POD 3 in mg/L | 4.653 | 2.435-8.889 | < 0.001 |
△ALB of ≥ 14.0% | 16.837 | 6.403-44.275 | < 0.001 |
ASA of ≥ 3 | 1.007 | 0.559-1.815 | 0.981 |
Clinical stage of ≥ II | 1.798 | 1.255-2.686 | 0.009 |
Mode of surgical approach | 1.206 | 0.588-2.475 | 0.610 |
Type of resection | 1.291 | 1.006-1.896 | 0.013 |
Degree of lymph node dissection ≥ 2 | 2.263 | 0.948-5.399 | 0.066 |
Operation time of ≥ 250 min | 1.621 | 0.896-2.931 | 0.110 |
Blood loss of ≥ 200 mL | 1.417 | 0.758-2.651 | 0.275 |
Table 3 Multivariate analysis of risk factors associated with postoperative complications
Characteristic | OR | 95%CI | P value |
Age ≥ 75 yr | 1.053 | 0.248-4.470 | 0.945 |
Sex | 0.572 | 0.237-1.380 | 0.214 |
BMI of < 18.5 kg/m2 | 0.147 | 0.013-1.666 | 0.122 |
Comorbidities | |||
Diabetes mellitus | 1.234 | 0.322-4.726 | 0.759 |
Hypertension | 0.989 | 0.397-2.463 | 0.981 |
Preoperative serum albumin of < 35 g/L | 0.914 | 0.897-1.067 | 0.093 |
Preoperative hemoglobin of < 120 g/L | 1.804 | 0.748-4.353 | 0.189 |
Preoperative CRP of ≥ 10 g/L | 1.008 | 0.210-4.840 | 0.993 |
CA 19-9 of ≥ 37 ng/mL | 1.197 | 0.431-3.327 | 0.730 |
CEA of ≥ 5 ng/mL | 0.794 | 0.233-2.706 | 0.713 |
Lymphocyte count of ≥ 3 × 109/L | 0.192 | 0.018-2.048 | 0.172 |
CRP on POD 3 in mg/L | 4.296 | 1.887-9.780 | 0.001 |
△ALB of ≥ 14.0% | 17.957 | 6.073-53.095 | < 0.001 |
ASA of ≥ 3 | 0.929 | 0.406-2.127 | 0.861 |
Clinical stage of ≥ II | 1.198 | 0.355-2.286 | 0.109 |
Mode of surgical approach | 1.737 | 0.576-5.235 | 0.327 |
Type of resection | 0.791 | 0.506-1.896 | 0.063 |
Degree of lymph node dissection ≥ 2 | 3.485 | 1.163-10.446 | 0.026 |
Operation time of ≥ 250 min | 1.448 | 0.624-3.355 | 0.389 |
Blood loss of ≥ 200 mL | 1.418 | 0.636-3.160 | 0.393 |
Table 4 Univariate analysis of postoperative complications associated with median value of ∆ALB
Characteristic | All, n = 223 | ∆ALB < 14.0%, n = 101 | ∆ALB ≥ 14.0%, n = 122 | P value |
Overall13 | 62 (27.8) | 5 (5.0) | 57 (46.7) | < 0.001 |
Mild complications13 | 40 (17.9) | 3 (3.0) | 37 (30.3) | < 0.001 |
Major complications13 | 22 (9.9) | 2 (2.0) | 20 (16.4) | < 0.001 |
Postoperative stay in d2 | 15.8 ± 8.6 | 14.1 ± 4.2 | 17.2 ± 10.8 | 0.007 |
CCI all patients4 | 0 (0-20.9) | 0 (0-0) | 8.7 (0-26.2) | < 0.001 |
- Citation: Liu ZJ, Ge XL, Ai SC, Wang HK, Sun F, Chen L, Guan WX. Postoperative decrease of serum albumin predicts short-term complications in patients undergoing gastric cancer resection. World J Gastroenterol 2017; 23(27): 4978-4985
- URL: https://www.wjgnet.com/1007-9327/full/v23/i27/4978.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i27.4978