Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases

doi:10.3748/wjg.v23.i26.4796

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Jul 14, 2017 (publication date) through May 3, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Jul 14, 2017; 23(26): 4796-4805
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4796

Table 1 Characteristics of the studied subjects n (%)

	Ulcerative colitis	Crohn’s disease	Control group
	n = 47	n = 38	n = 50
Men	22 (46.81)	20 (52.63)	35 (70)
Age, yr	37 (26-47)^b	29.5 (22-34)^a	36 (29-46)
BMI, kg/m²	22.1 (20.5-25)	20.43 (18.38-22.9)	23.9 (22.2-25.3)
Smoking	9 (19.15)	15 (39.47)	17 (34)
Disease duration, yr	5 (2.5-9)	3.5 (2-6)	NA
Surgery	0 (0)^b	11 (28.9)	NA
Complications	3 (6.4)^b	11 (28.9)	NA
Location
Rectum	7 (14.9)	NA	NA
Left-sided	25 (53.2)	NA	NA
Extensive colitis	15 (31.9)	NA	NA
Ileal	NA	12 (31.6)	NA
Colonic	NA	3 (7.9)	NA
Ileocolonic	NA	23 (60.5)	NA
Pregnancies, n	17	12	13
Miscarriages, n	0	1	1

^aP < 0.05 vs the control group,

^bP < 0.05 vs the Crohn’s disease group. BMI: Body mass index.

Table 2 Comparison of active and inactive ulcerative colitis groups and controls

	Ulcerative colitis inactive	Ulcerative colitis active	Control group
	n = 21	n = 26	n = 50
Disease activity index (points)	2.33 ± 1.68^b	7.96 ± 1.91	NA
White blood cells, × 10³/μL	6.89 (4.91-7.74)	8.22 (5.54-9.65)	6.75 (6.1-7.9)
Platelet coun, × 10³/μL	286.02 (216-303)^b	326 (252-379)^a	229.5 (199-268)
Haematocrit (%)	43.4 (39.95-44.55)^b	39.85 (36.8-42.2)	41.1 (39.5-43)
Haemoglobin, g/dL	13.5 ± 1.67	12.7 ± 1.5^a	14.3 ± 1.1
Fibrinogen, g/L	2.52 (2.19-3.92)^b	4.97 (3.83-6.99)^a	3.05 (2.48-4.16)
CRP, mg/L	1.24 (0.79-1.89)^b	10.7 (7.22-20.8)^a	1.68 (.98-2.24)

^aP < 0.05 vs the control group,

^bP < 0.05 vs active ulcerative colitis group. CRP: C-reactive protein.

Table 3 Comparison of active and inactive Crohn’s disease groups and controls

	Crohn’s disease inactive	Crohn’s disease active	Control group
	n = 16	n = 22	n = 50
CDAI (points)	83.38 ± 33.30^b	236.05 ± 63.46	NA
White blood cells, × 10³/μL	6.74 (5.47-7.08)	6.71 (4.91-9.02)	6.75 (6.1-7.9)
Platelet count, × 10³/μL	291.5 (209-336)^b	324.5 (289-386)^a	229.5 (199-268)
Haematocrit, %	42.7 (39.75-45.1)^b	37.9 (35.8-39.8)^a	41.1 (39.5-43)
Haemoglobin, g/dL	13.99 ± 1.36^b	12.15 ± 1.4^a	14.3 ± 1.1
Fibrinogen, g/L	3.81 (2.63-4.7)^b	6.52 (4.76-8.26)^a	3.05 (2.48-4.16)
CRP, mg/L	2.95 (1.19-5.72)^b	33.8 (16.4-72.3)^a	1.68 (0.98-2.24)

^aP < 0.05 vs the control group,

^bP < 0.05 vs active Crohn’s disease group. CDAI: Crohn’s disease activity index; CRP: C-reactive protein.

Table 4 Characteristics of markers in active and inactive ulcerative colitis groups and controls

	Ulcerative colitis inactive	Ulcerative colitis active	Control group
	n = 21	n = 26	n = 50
VWF:RCo, IU/dL	120.61 ± 36.33	134.2 ± 46.7	114.03 ± 24.67
VWF:Ag, IU/dL	139.6 (110.3-166.5)^a	144.95 (120.8-180.5)^a	106.65 (90.7-122.5)
VWF:CB, IU/dL	84.93 ± 13.88^a	78.87 ± 14.99^a	97.99 ± 10.3
ADAMTS13: Ag (IU/dL)	86.15 ± 10.17^a,^b	66.39 ± 11.45^a	103.86 ± 10.84
ADAMTS13act (IU/dL)	81.2 (79.4-92.9)^b	65.05 (55.7-75.1)^a	111.0 (97.8-122.8)
VWF:RCo/VWF:Ag	0.96 (0.92-0.97)	0.97 (0.87-1.01)	0.97 (0.91-1.15)
VWF:CB/VWF:Ag	0.68 (0.50-0.79)^a	0.5 (0.45-0.70)^a	0.91 (0.80-1.05)
VWF:Ag/ADAMTS13act	1.54 (1.34-2.07)^a	2.22 (1.65-2.84)^a	0.98 (0.79-1.20)
ADAMTS13act/ADAMTS13:Ag	1.01 (0.97-1.02)	1.0 (0.97-1.03)	1.02 (0.94-1.18)

^aP < 0.05 vs the control group,

^bP < 0.05 vs active ulcerative colitis group.

Table 5 Characteristics of markers in active and inactive Crohn’s disease groups and controls

	Crohn’s disease inactive	Crohn’s disease active	Control group
	n = 16	n = 22	n = 50
VWF:RCo, IU/dL	143.47 ± 46.12	157.04 ± 61.03^a	114.03 ± 24.67
VWF:Ag, IU/dL	135.4 (116.85-175.65)^a	182.98 (130.4-219.8)^a	106.65 (90.7-122.5)
VWF:CB, IU/dL	98.85 (86.15-102.25)	89.3 (80.6-99.7)	98.05 (91.9-101.8)
ADAMTS13:Ag, IU/dL	104.44 ± 9.96	99.29 ± 15.33	103.86 ± 10.84
ADAMTS13act, IU/dL	104.82 ± 8.61	94.48 ± 15.74^a	111.05 ± 17.69
VWFRCo/VWF:Ag	0.96 (0.95-1.00)	0.96 (0.79-1.01)	0.97 (0.91-1.15)
VWF:CB/VWF:Ag	0.65 (0.45-0.87)^a	0.54 (0.45-0.65)^a	0.91 (0.80-1.05)
VWF:Ag/ADAMTS13act	1.26 (1.12-1.62)^a	1.88 (1.48-2.56)^a	0.98 (0.79-1.20)
ADAMTS13act/ADAMTS13:Ag	0.99 (0.94-1.05)	0.96 (0.92-1.03)	1.02 (0.94-1.18)

^aP < 0.05 vs the control group.

Table 6 Results of multiple linear regression in ulcerative colitis patients

	ADAMTS13:Ag	ADAMTS13act
Platelets	β = -0.03 (95%CI: -0.07; -0.01)	-
	P = 0.044
C-reactive protein	β = -0.19 (95%CI: -0.33; -0.05)	β = -0.25 (95%CI: -0.38; -0.12)
	P = 0.103	P < 0.001
Disease activity	β = -2.27 (95%CI: -3.18; -1.35)	β = -0.2.27 (95%CI: -3.48; -1.86)
	P < 0.001	P < 0.001
adj.R²	65.3%	69.5%

Results show the estimated value of parameter, P-value for the t-test and adjusted determinant coefficient. Additional, 95%CI of parameter’s estimate when P < 0.05. adj.R²: Adjusted determinant coefficient.

Citation: Cibor D, Owczarek D, Butenas S, Salapa K, Mach T, Undas A. Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases. World J Gastroenterol 2017; 23(26): 4796-4805
URL: https://www.wjgnet.com/1007-9327/full/v23/i26/4796.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i26.4796