New magnifying endoscopic classification for superficial esophageal squamous cell carcinoma

Table 1 Baseline characteristics of patients with superficial esophageal squamous cell carcinoma n (%)

Characteristics
Male/female	62/7
Mean age, yr (range)	66 (47-81)
Location
Upper esophagus	3 (4.3)
Mid-esophagus	52 (74.3)
Lower esophagus	15 (21.4)
Macroscopic shape
Elevated	24 (34.3)
Flat	27 (38.6)
Depressed	19 (27.1)
Mean tumor size, mm (range)	25 (4-70)
Differentiation
Well differentiated	34 (48.6)
Moderately differentiated	31 (44.3)
Poorly differentiated	5 (7.1)
Depth of invasion
Mucosa	43 (61.4)
m1	8
m2	20
m3	15
Submucosa	27 (38.6)
sm1	3
sm2	24
Resection method
Endoscopic resection	32 (45.7)
Surgical resection	38 (54.3)

Table 2 Comparison of pretreatment diagnosis by magnifying endoscopy with narrow-band imaging and histopathology of superficial esophageal squamous cell carcinoma

ME-NBI	No. of cases	Histopathology, n
		m1-m2	m3-sm1	sm2
B1	20	20	0	0
B2	31	8	17	6
B3	19	0	1	18

ME-NBI: Magnifying endoscopy with narrow-band imaging.

Table 3 Accuracy, sensitivity, specificity, and positive and negative predictive values of magnifying endoscopy with narrow-band imaging for predicting depth of invasion of superficial esophageal squamous cell carcinoma (%)

ME-NBI	Accuracy (95%CI)	Sensitivity (95%CI)	Specificity (95%CI)	PPV (95%CI)	NPV (95%CI)
B1	88.6 (78.2-94.6)	71.4 (51.1-86.0)	100 (89.6-100)	100 (80.0-100)	84.0 (70.3-92.4)
B2	78.6 (66.8-87.1)	94.4 (70.6-99.7)	73.1 (58.7-84.0)	54.8 (36.3-72.2)	97.4 (84.9-99.9)
B3	90.0 (79.9-95.5)	75.0 (52.9-89.4)	97.8 (87.0-99.9)	94.7 (71.9-99.7)	88.2 (75.4-95.1)

ME-NBI: Magnifying endoscopy with narrow-band imaging; PPV: Positive predictive value; NPV: Negative predictive value.