Copyright ©The Author(s) 2017.
World J Gastroenterol. Jun 28, 2017; 23(24): 4330-4340
Published online Jun 28, 2017. doi: 10.3748/wjg.v23.i24.4330
Table 1 Expression of Hedgehog pathway protein markers in hepatocarcinoma tissues
Ref.SMOSHHPTCHGli1Clinical correlation
Sicklick et al[52], 200642.90% (3-fold higher than normal tissues)50% (3- to 4-fold higher than normal tissues)Tumour size
21.4% (8- to 9-fold higher than normal tissues)
Huang et al[53], 200659% positive tumours56% positive tumours72% positive tumoursTumour size
Che et al[59], 201232.61% positive tumours60.87% positive tumours50% positive tumours54.35% positive tumoursGli1 with disease-free survival (DFS) and overall survival (OS)
Dugum et al[54], 2016100% tumoural and surrounding tissue100% tumoural and surrounding tissue, with higher expression in tumour tissue100% tumoural and surrounding tissueTendency to correlation with HCC recurrence after liver transplantation