Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis

doi:10.3748/wjg.v23.i22.4039

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2017; 23(22): 4039-4046
Published online Jun 14, 2017. doi: 10.3748/wjg.v23.i22.4039

Table 1 Characteristics of study population (inflammatory bowel disease)

	Controls	Active IBD	Inactive IBD	P value
n	122	133	38
Age (yr)	38.5 ± 14.2	37.5 ± 13.4	37.6 ± 10.5	0.825
Gender (F/M)	55/67	63/70	16/22	0.833

Data on age is presented as mean ± SD and analyzed using one-way ANOVA; data on gender distribution (F-females, M-males) was analyzed using χ² test. IBD: Inflammatory bowel disease.

Table 2 Characteristics of study population (Crohn’s disease and ulcerative colitis)

	CD active	CD inactive	UC active	UC inactive	P value
N	81	16	52	22
Age (yr)	35.3 ± 12.7	35.7 ± 10.5	40.9 ± 13.8	39 ± 10.5	0.081
Gender (F/M)	42/39	5/11	21/31	11/11	0.346
Hb (g/dL)	12 ± 1.9	13.8 ± 2.1	12.2 ± 2.4	12.8 ± 1.5	0.028
PLT (× 10³/mm³)	397 (297-483)	283 (215-344)	314 (283-434)	264 (226-327)	< 0.001
WBC (× 10³/mm³)	7.89 (5.9-10.8)	6.24 (5.5-7.3)	7.91 (6.1-9)	6.2 (5.1-7.6)	0.046
Protein (g/dL)	6.97 ± 0.99	7.26 ± 0.74	6.77 ± 0.88	7.23 ± 0.54	0.152

Data on age, hemoglobin (Hb), and total protein concentration presented as mean ± SD and analyzed using one-way ANOVA; data on platelet (PLT) and leukocyte (WBC) counts presented as medians with interquartile range and analyzed using Kruskal-Wallis H test; data on gender distribution (F-females, M-males) was analyzed using χ² test. CD: Crohn’s disease; UC: Ulcerative colitis.

Table 3 Interleukin-9 association with proinflammatory, angiogenic and Th1 and Th2 subset-specific cytokines

	CD active	CD inactive	UC active	UC inactive	Controls
IL1β	NS	0.58, P = 0.020	0.42, P = 0.002	0.76, P < 0.0001	0.51, P < 0.0001¹
IL6	NS	0.58, P = 0.018	0.38, P = 0.005	0.77, P < 0.0001¹	0.33, P < 0.001
IL13	0.48, P < 0.0001¹	0.62, P = 0.010¹	NS	NS	0.46, P < 0.0001¹
IFNγ	0.29, P = 0.008	NS	0.51, P = 0.0001¹	0.74, P = 0.0001	NS
TNFα	NS	NS	NS	0.65, P = 0.001	0.19, P = 0.045
VEGFA	0.37, P < 0.001¹	0.77, P < 0.001¹	0.38, P = 0.006	0.46, P = 0.033	0.36, P = 0.0001

¹Independently associated with IL9 in multivariate analysis (stepwise method). CD: Crohn’s disease; UC: Ulcerative colitis.

Citation: Matusiewicz M, Neubauer K, Bednarz-Misa I, Gorska S, Krzystek-Korpacka M. Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis. World J Gastroenterol 2017; 23(22): 4039-4046
URL: https://www.wjgnet.com/1007-9327/full/v23/i22/4039.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i22.4039