Wall shear stress in portal vein of cirrhotic patients with portal hypertension

Table 1 Geometric and hemodynamic parameters of the idealized portal vein system model

Vein	Length (cm)	Diameter (cm)		Inlet velocity (cm/s)
		Control	PH	Control	PH
PV	5.1	1.03	1.31	-	-
SV	9.6	0.63	0.95	17	16
SMV	8.2	0.92	0.94	21	17
LPV	2.1	0.73	0.75	-	-
RPV	2.1	0.83	0.78	-	-

PV: Portal vein; SV: Splenic vein; SMV: Superior mesenteric vein; LPV: Left PV; RPV: Right PV.

Table 2 Clinical characteristics of patients with cirrhosis and portal hypertension and healthy controls

Parameters	Cirrhotic(n = 10)	Non-cirrhotic(n = 5)	P value
Sex, M/F	7/3	3/2	0.73
Age, yr	41 (31-58)	40 (29-53)	0.85
AST, in UI/L	52 (44-61)	30 (25-35)	0.01
ALT, UI/L	44 (41-56)	30 (28-31)	0.01
Platelet count, × 109/L	48 (42-57)	235 (206-265)	< 0.01
Diameter, in mm
PV	12.9 (11.0-14.3)	10.3 (9.9-10.7)	0.02
SV	10.0 (8.4-10.2)	6.3 (6.1-6.5)	< 0.01
SMV	8.6 (7.7-10.7)	9.3 (8.9-9.6)	0.77

Data are shown as median (interquartile range), except for age shown as median (range). ALT: Alanine transaminase; AST: Aspartate transaminase.

Table 3 Wall shear stress in left and right walls of the portal vein in control and portal hypertension groups

	Control group		PH group
	Right wall	Left wall	Right wall	Left wall
WSS, dyn/cm2	16.3	8.6	9.8	4.4

Data are shown as median. PH: Portal hypertension. WSS: Wall shear stress.

Table 4 Wall shear stress in right and left walls for different superior mesenteric vein-splenic vein angles

	Right wall			Left wall
	85°	105°	125°	85°	105°	125°
WSS, dyn/cm2	16.3	12.1	9	8.6	8.7	9.4

Data are shown as median. WSS: Wall shear stress.

Table 5 Wall shear stress in left and right walls for different portal vein-splenic vein angles

	Right wall			Left wall
	90°	110°	130°	90°	110°	130°
WSS, dyn/cm2	13.7	16.3	13.3	6.9	8.6	9.7

Data are shown as median. WSS: Wall shear stress.