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©The Author(s) 2017.
World J Gastroenterol. May 14, 2017; 23(18): 3262-3268
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3262
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3262
Table 1 Vital signs of pigs at each time point (mean ± SD)
Time (h) | Heart rate (per min) | Respiratory rate (per min) | SPO2 (%) | Arterial pressure (mmHg) |
0 | 84 ± 4 | 25 ± 13 | 96 ± 2 | 103 ± 4 |
1 | 79 ± 4 | 21 ± 3 | 91 ± 7 | 100 ± 5 |
2 | 74 ± 4 | 23 ± 5 | 94 ± 5 | 101 ± 9 |
3 | 80 ± 5 | 21 ± 3 | 96 ± 2 | 99 ± 6 |
4 | 89 ± 8 | 24 ± 6 | 93 ± 7 | 96 ± 11 |
5 | 91 ± 7 | 21 ± 4 | 92 ± 3 | 91 ± 7 |
6 | 79 ± 4 | 19 ± 3 | 94 ± 5 | 98 ± 5 |
7 | 76 ± 7 | 20 ± 3 | 95 ± 2 | 100 ± 2 |
8 | 83 ± 5 | 23 ± 6 | 92 ± 5 | 97 ± 6 |
Table 2 Effect of acetaminophen administration on serum biochemical parameters
Indicator | Before administration | 20 h after administration | 28 h after administration | |||
Treatment | Control | Treatment | Control | Treatment | Control | |
AST (U/L) | 37.8 ± 5.5 | 44.8 ± 6.5 | 460.6 ± 22.9a | 410.2 ± 13.5a | 108.8 ± 13.2c | 522.1 ± 29.5 |
NH3 (g/dL) | 26.9 ± 4.1 | 37.4 ± 5.6 | 134.1 ± 11.1a | 149.1 ± 8.3a | 96.7 ± 16.9c | 170.3 ± 23.9 |
Tbil (μmol/L) | 22.4 ± 1.9 | 24.5 ± 1.1 | 97.8 ± 15.3a | 105.5 ± 6.1a | 66.7 ± 12.4c | 170.2 ± 37.8 |
Cr (μmol/L) | 56.1 ± 4.4 | 55.9 ± 7.6 | 175.7 ± 19.5a | 166 ± 10.3a | 119.4 ± 10.4c | 263.1 ± 9.1 |
ALB (g/L) | 35.9 ± 2.1 | 31.7 ± 0.9 | 22.2 ± 3.2a | 20.4 ± 2.8a | 21.4 ± 1.3 | 19 ± 1 |
PT (s) | 11.6 ± 3.2 | 13 ± 3.0 | 60.8 ± 9.3a | 70.2 ± 4.9a | 73.0 ± 7.7 | 85.8 ± 9.2 |
- Citation: He GL, Feng L, Cai L, Zhou CJ, Cheng Y, Jiang ZS, Pan MX, Gao Y. Artificial liver support in pigs with acetaminophen-induced acute liver failure. World J Gastroenterol 2017; 23(18): 3262-3268
- URL: https://www.wjgnet.com/1007-9327/full/v23/i18/3262.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i18.3262