Artificial liver support in pigs with acetaminophen-induced acute liver failure

Table 1 Vital signs of pigs at each time point (mean ± SD)

Time (h)	Heart rate (per min)	Respiratory rate (per min)	SPO2 (%)	Arterial pressure (mmHg)
0	84 ± 4	25 ± 13	96 ± 2	103 ± 4
1	79 ± 4	21 ± 3	91 ± 7	100 ± 5
2	74 ± 4	23 ± 5	94 ± 5	101 ± 9
3	80 ± 5	21 ± 3	96 ± 2	99 ± 6
4	89 ± 8	24 ± 6	93 ± 7	96 ± 11
5	91 ± 7	21 ± 4	92 ± 3	91 ± 7
6	79 ± 4	19 ± 3	94 ± 5	98 ± 5
7	76 ± 7	20 ± 3	95 ± 2	100 ± 2
8	83 ± 5	23 ± 6	92 ± 5	97 ± 6

Table 2 Effect of acetaminophen administration on serum biochemical parameters

Indicator	Before administration		20 h after administration		28 h after administration
	Treatment	Control	Treatment	Control	Treatment	Control
AST (U/L)	37.8 ± 5.5	44.8 ± 6.5	460.6 ± 22.9a	410.2 ± 13.5a	108.8 ± 13.2c	522.1 ± 29.5
NH3 (g/dL)	26.9 ± 4.1	37.4 ± 5.6	134.1 ± 11.1a	149.1 ± 8.3a	96.7 ± 16.9c	170.3 ± 23.9
Tbil (μmol/L)	22.4 ± 1.9	24.5 ± 1.1	97.8 ± 15.3a	105.5 ± 6.1a	66.7 ± 12.4c	170.2 ± 37.8
Cr (μmol/L)	56.1 ± 4.4	55.9 ± 7.6	175.7 ± 19.5a	166 ± 10.3a	119.4 ± 10.4c	263.1 ± 9.1
ALB (g/L)	35.9 ± 2.1	31.7 ± 0.9	22.2 ± 3.2a	20.4 ± 2.8a	21.4 ± 1.3	19 ± 1
PT (s)	11.6 ± 3.2	13 ± 3.0	60.8 ± 9.3a	70.2 ± 4.9a	73.0 ± 7.7	85.8 ± 9.2

^aP < 0.05, 20 h after administration vs before administration;

^cP < 0.05, treatment vs control, 28 h after administration.