Copyright
©The Author(s) 2017.
World J Gastroenterol. May 7, 2017; 23(17): 3174-3183
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3174
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3174
Patients characteristics | Group 1 (n = 24) | Group 2 (n = 30) | P value |
Age (yr) | 64.7 (56.0-67.9) | 64.2 (60.0-67.6) | 0.889 |
Gender, % men | 75 | 77 | 0.887 |
Body mass index (kg/m2) | 27.6 (25.0-30.3) | 26.2 (25.0-29.1) | 0.623 |
Smoking, % current smokers | 20.8 | 10.7 | 0.313 |
Barrett’s esophagus length (cm) | |||
C (circular extension) | 2 (1-6) | 1 (0-3) | 0.099 |
M (maximal extension) | 5 (4-8) | 5 (3-7) | 0.278 |
Variable | Group 1, baseline(n = 23) | Group 1, no reflux(n = 23) | P value | Group 2, reflux(n = 14) | Group 2, no reflux(n = 16) | P value |
Squamous epithelium | ||||||
Dilated intercellular space (%) | 87.0 | 73.9 | < 0.05 | 78.6 | 68.8 | 0.50 |
Basal cell thickness (% score 0/1/2) | 4.3/82.7/13.0 | 21.7/69.6/8.7 | 0.22 | 50.0/50.0/0 | 12.5/87.5/0 | < 0.05 |
Papillary length (% score 0/1/2) | 0/34.8/65.2 | 8.7/52.2/39.1 | < 0.05 | 7.1/42.9/50.0 | 18.8/43.7/37.5 | 0.53 |
Epithelial neutrophils and eosinophils (% score 0/1/2) | 39.2/30.4/30.4 | 47.8/26.1/26.1 | 0.86 | 35.7/50.0/14.3 | 62.5/25/12.5 | 0.27 |
Epithelial mononuclear cells (% score 0/1/2) | 60.9/39.1/0 | 87.0/13.0/0 | 0.09 | 57.1/42.9/0 | 56.3/43.7/0 | 0.47 |
Proximal BE | ||||||
Epithelial neutrophils and eosinophils (% score 0/1/2) | 43.5/30.4/26.1 | 47.8/30.4/21.7 | 0.06 | 42.9/21.4/35.7 | 81.3/6.2/12.5 | < 0.05 |
Epithelial mononuclear cells (% score 0/1/2) | 91.3/8.7/0 | 95.7/4.3/0 | 0.26 | 92.9/7.1/0 | 93.7/6.3/0 | 0.24 |
Distal BE | ||||||
Epithelial neutrophils and eosinophils (% score 0/1/2) | 78.3/8.7/13.0 | 82.6/13/4.4 | 0.74 | 85.7/0/14.3 | 43.8/50/6.2 | < 0.05 |
Epithelial mononuclear cells (% score 0/1/2) | 73.9/13.0/13.0 | 56.5/39.1/4.4 | 0.10 | 92.9/7.1/0 | 100/0/0 | 0.09 |
- Citation: Baldaque-Silva F, Vieth M, Debel M, Håkanson B, Thorell A, Lunet N, Song H, Mascarenhas-Saraiva M, Pereira G, Lundell L, Marschall HU. Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett’s esophagus. World J Gastroenterol 2017; 23(17): 3174-3183
- URL: https://www.wjgnet.com/1007-9327/full/v23/i17/3174.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i17.3174