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©The Author(s) 2017.
World J Gastroenterol. Apr 21, 2017; 23(15): 2802-2810
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2802
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2802
Table 1 Baseline demographic and clinical characteristics of all subjects with normal alanine aminotransferase level
All (n = 155) | HBeAg-positive (n = 86) | HBeAg-negative (n = 69) | |
Age (yr) | 39.7 ± 9.9 | 42.9 ± 8.9 | 37.2 ± 9.9 |
Male, n (%) | 84 (54.2) | 52 (60.9) | 34 (48.8) |
HBV DNA (logIU/mL) | 5.8 ± 2.1 | 4.3 ± 1.4 | 6.9 ± 1.9 |
WBC (109/mL) | 5.9 ± 3.1 | 5.9 ± 4.4 | 5.8 ± 1.5 |
PLT (109/mL) | 190.08 ± 62.9 | 182.29 ± 57.7 | 196.3 ± 66.5 |
ALT (U/L) | 26.0 ± 8.7 | 25.0 ± 9.2 | 26.8 ± 8.1 |
AST (U/L) | 24.6 ± 6.6 | 24.1 ± 6.1 | 25.1 ± 7.0 |
ALP (U/L) | 68.1 ± 20.1 | 67.1 ± 17.2 | 68.9 ± 22.2 |
GGT (U/L) | 21.8 ± 14.6 | 21.1 ± 11.9 | 22.3 ± 16.5 |
TB (g/L) | 13.6 ± 6.7 | 13.6 ± 7.5 | 13.6 ± 6.1 |
PT (s) | 11.4 ± 1.1 | 11.4 ± 1.0 | 11.4 ± 1.4 |
TT (s) | 19.1 ± 1.7 | 18.8 ± 1.8 | 19.3 ± 1.5 |
A/G ratio | 1.7 ± 0.4 | 1.8 ± 0.4 | 1.7 ± 0.4 |
Cr (μmol/L) | 70.2 ± 14.6 | 70.0 ± 15.2 | 70.4 ± 14.2 |
TBA (μmol/L) | 8.7 ± 14.1 | 6.3 ± 6.0 | 10.7 ± 17.9 |
GLB (g/L) | 27.2 ± 4.3 | 26.9 ± 4.1 | 27.5 ± 4.4 |
ALB (g/L) | 45.6 ± 4.0 | 46.7 ± 4.0 | 44.5 ± 3.9 |
Table 2 Demographic and clinical characteristics of carriers with and without significant liver changes
Significant necroinflammation (n = 42) | No significant necroinflammation (n = 113) | P value | Significant fibrosis (n = 24) | No significant fibrosis (n = 131) | P value | |
Age (yr) | 40.0 ± 9.3 | 39.7 ± 10.1 | 0.854 | 41.3 ± 10.3 | 39.5 ± 9.8 | 0.416 |
Male, n (%) | 13 | 79 | 0.417 | 20 | 23 | 0.505 |
HBV DNA (logIU/mL) | 6.0 ± 2.0 | 5.7 ± 2.2 | 0.368 | 5.6 ± 2.0 | 5.8 ± 2.1 | 0.733 |
WBC (109/mL) | 6.2 ± 5.7 | 5.7 ± 1.4 | 0.560 | 4.9 ± 1.2 | 6.0 ± 3.3 | 0.117 |
PLT (109/mL) | 170.2 ± 58.4 | 197.5 ± 63.2 | 0.016 | 150.3 ± 51.1 | 197.4 ± 62.3 | 0.001 |
ALT (U/L) | 29.6 ± 8.8 | 24.6 ± 8.3 | 0.001 | 29.7 ± 8.0 | 25.3 ± 8.6 | 0.116 |
AST (U/L) | 27.5 ± 6.0 | 23.6 ± 6.0 | 0.004 | 27.8 ± 6.4 | 24.1 ± 6.6 | 0.012 |
ALP (U/L) | 70.4 ± 25.0 | 67.2 ± 17.9 | 0.463 | 78.7 ± 29.4 | 66.1 ± 17.3 | 0.004 |
GGT (U/L) | 25.8 ± 19.4 | 20.3 ± 12.1 | 0.423 | 33.9 ± 25.4 | 19.6 ± 10.3 | 0.000 |
TB (g/L) | 14.1 ± 6.9 | 13.4 ± 6.7 | 0.538 | 16.0 ± 7.2 | 13.2 ± 6.6 | 0.057 |
PT (s) | 11.6 ± 1.0 | 11.3 ± 1.2 | 0.100 | 11.7 ± 1.0 | 11.3 ± 1.2 | 0.152 |
TT (s) | 19.4 ± 1.7 | 19.0 ± 1.6 | 0.235 | 19.2 ± 1.8 | 19.1 ± 1.6 | 0.776 |
A/G ratio | 1.8 ± 0.4 | 1.7 ± 0.4 | 0.173 | 1.7 ± 0.3 | 1.8 ± 0.4 | 0.700 |
Cr (μmol/L) | 66.7 ± 14.6 | 71.5 ± 14.4 | 0.070 | 71.8 ± 14.2 | 69.9 ± 14.7 | 0.557 |
TBA (μmol/L) | 9.0 ± 8.1 | 8.7 ± 15.7 | 0.900 | 16.8 ± 30.5 | 7.3 ± 7.4 | 0.002 |
GLB (g/L) | 26.5 ± 4.3 | 27.5 ± 4.2 | 0.183 | 27.3 ± 3.9 | 27.2 ± 4.3 | 0.915 |
ALB (g/L) | 45.1 ± 3.4 | 45.8 ± 4.2 | 0.335 | 44.2 ± 3.5 | 45.9 ± 4.1 | 0.058 |
Table 3 Univariate and multivariate logistic regression analysis of risk factors of significant necroinflammation and fibrosis
Significant necroinflammation | Significant fibrosis | |||||||
Univariate | Multivariate | Univariate | Multivariate | |||||
OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | OR (95%CI) | P value | |
Age (yr) | 0.994 (0.949, 1.042) | 0.812 | 1.003 (0.968, 1.040) | 0.120 | ||||
Male | 1.351 (0.530, 3.440) | 0.529 | 1.346 (0.656, 2.760) | 0.418 | ||||
HBV-DNA (logIU/mL) | 1.249 (0.978, 1.595) | 0.075 | 1.078 (0.910, 1.276) | 0.385 | ||||
WBC (109/mL) | 0.907 (0.648, 1.269) | 0.569 | 0.611 (0.359, 1.039) | 0.069 | ||||
PLT (109/mL) | 0.990 (0.980, 0.999) | 0.03 | 0.692 (0.646, 0.709) | 0.003 | 0.688 (0.641, 0.723) | 0.008 | ||
ALT (U/L) | 1.081 (1.020, 1.147) | 0.009 | 1.059 (0.985,1.139) | 0.121 | ||||
AST (U/L) | 1.590 (1.502, 1.651) | 0.0002 | 1.682 (1.613, 1.704) | 0.007 | 1.091 (1.006, 1.185) | 0.036 | ||
ALP (U/L) | 1.018 (0.994, 1.042) | 0.139 | 1.051 (1.015, 1.089) | 0.006 | ||||
GGT (U/L) | 1.021 (0.993, 1.050) | 0.151 | 1.524 (1.491, 1.587) | 0.007 | 1.453 (1.406, 1.511) | 0.036 | ||
TB (g/L) | 0.988 (0.921, 1.059) | 0.723 | 1.025 (0.945, 1.112) | 0.547 | ||||
PT (s) | 1.683 (0.941, 3.009) | 0.079 | 2.022 (1.012, 4.042) | 0.083 | ||||
TT (s) | 1.235 (0.945, 1.615) | 0.122 | 1.294 (0.948, 1.768) | 0.105 | ||||
A/G ratio | 2.053 (0.570, 7.393) | 0.271 | 0.580 (0.099, 3.394) | 0.546 | ||||
Cr (μmol/L) | 0.974 (0.941, 1.009) | 0.143 | 1.000 (0.957, 1.046) | 0.997 | ||||
TBA (μmol/L) | 1.063 (0.998, 1.131) | 0.057 | 1.065 (1.001, 1.133) | 0.048 | ||||
GLB (g/L) | 0.953 (0.862, 1.053) | 0.345 | 1.001 (0.877, 1.143) | 0.986 | ||||
ALB (g/L) | 0.931 (0.836, 1.036) | 0.191 | 0.923 (0.805, 1.058) | 0.250 |
- Citation: Cheng JL, Wang XL, Yang SG, Zhao H, Wu JJ, Li LJ. Non-ALT biomarkers for markedly abnormal liver histology among Chinese persistently normal alanine aminotransferase-chronic hepatitis B patients. World J Gastroenterol 2017; 23(15): 2802-2810
- URL: https://www.wjgnet.com/1007-9327/full/v23/i15/2802.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i15.2802