Changes in human hepatic metabolism in steatosis and cirrhosis

Table 1 Patient demographics for samples used for ¹H-NMR analysis of whole liver tissue

Group	Age	Sex	Height (cm)	Weight (kg)	BMI	ALT (IU/L)	AST (IU/L)	Bilirubin (μmol/L)
ARLD	40	F	162	86.7	33	21	-	3
ARLD	49	M	188	104	29.4	33	66	37
ARLD	54	M	179	101	31.5	14	-	135
ARLD	65	F	162	71	27.1	19	-	75
ARLD	49	M	183	66	19.7	43	59	30
mean	52 ± 9.12		172.75 ± 12.1	90.68 ± 17.3	30.25 ± 5.21	21.75 ± 11.7	66 ± 4.94	62.5 ± 51.1
NASH	60	M	173	110	36.8	29	66	40
NASH	61	M	175	106	34.6	45	126	17
NASH	51	M	178	112	35.3	25	32	30
NASH	51	F	158	57	22.8	12	46	191
NASH	50	F	157	64	26	32	74	145
NASH	49	F	162	86	32.8	54	72	97
NASH	60	M	175	95	31	33	87	90
NASH	52	M	170	113	39.1	37	47	66
NASH	47	M	169	109	38.2	34	51	19
NASH	70	F	164	82	30.5	28	32	13
NASH	44	M	165	101	37.1	36	62	109
NASH	52	M	173	103	34.4	24	37	44
NASH	60	M	179	123	32.1	22	41	27
NASH	61	M	178	97	30.6	18	34	50
mean	55 ± 7.1		169.7 ± 7.4	97 ± 18.9	32.95 ± 4.6	30.6 ± 10.8	58 ± 26.2	67 ± 53.2
Donor	-	-	-	-	-	-	-	-
Donor	-	-	-	-	-	119	-	14
Donor	-	-	-	-	-	11	-	14
Donor	-	-	-	-	-	-	-	-
Donor	77	M	176	80	25.8	55	-	18
Donor	74	F	-	-	-	-	-	-
Donor	-	-	-	-	-	-	-	-
Donor	-	-	-	-	-	9	-	11
Donor	39	M	176	68.7	22.2	63	126	15
Donor	-	-	-	-	-	-	-	-
Donor	46	M	171	51.3	17.54	30	N/A	23
Donor	-	-	-	-	-	-	-	-
Donor	-	-	-	-	-	-	-	-
Donor	-	-	-	-	-	-	-	-
Donor	-	-	-	-	-	-	-	-
Donor	55	F	163	56.1	21.1	48	97	7

Demographics of our patients at time of transplantation surgery - indicates data unavailable. In particular for most organ donors, constraints of our ethical approval process meant we were unable to access anonymized clinical demographic information from deceased donors. Thus we only have data for selected steatotic donor liver samples. BMI: Body mass index; ALT: Alanine aminotransferase; AST: Aspartate transaminase; NASH: Nonalcoholic steatohepatitis; ARLD: Alcohol-related liver damage.