Effect of treatment failure on the CagA EPIYA motif in Helicobacter pylori strains from Colombian subjects

doi:10.3748/wjg.v23.i11.1980

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2017; 23(11): 1980-1989
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.1980

Table 1 Comparison of the cagA (EPIYA motifs) and vacA s and m genotypes found before and after anti-Helicobacter pylori treatment in isolates from patients with treatment failure

Patient (n = 10)	Anatomic location	*Anti-H. pylori* treatment**
		Genotype		EPIYA motifs (bp)
		Before	After	Before	After
SV314	Antrum lesser curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	495	200
SV314	Antrum greater curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	495/200	200
SV318	Antrum lesser curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	495	595/495
	Antrum greater curvature	cagA+/vacA s1m1¹	No change	200	595/495
	Body greater curvature	cagA+/vacA s1m1¹	CagA+/vacA s1m1	495/200	NA
SV377	Antrum lesser curvature	cagA+/vacA s2m2²	cagA+/vacA s1m1	695/595/495/200	200
	Antrum greater curvature	cagA+/vacA s2m2²	cagA+/vacA s1m1	NA	200
	Body greater curvature	cagA+/vacA s2m2²	Undefined	200	495
SV415	Antrum lesser curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	495	495/200
SV415	Body greater curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	495/200	495
SV444	Body greater curvature	cagA+/vacA s1m1	No change	595	595
SV471	Antrum greater curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	495	595
SV471	Body greater curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	495/200	595
SV480	Antrum lesser curvature	cagA+/vacA s2m2²	cagA+/vacA s1m1¹	595/495	595/200
SV480	Body greater curvature	cagA+/vacA s2m2²	cagA+/vacA s1/m1	200	595
SV509	Antrum lesser curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	200	NA
SV509	Antrum greater curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	200	495
SV512	Antrum greater curvature	cagA+/vacA s1m1¹	cagA+/ vacAs1m1	495	NA
SV512	Body greater curvature	cagA+/vacA s1m1¹	No change	495/200	595
SV526	Antrum lesser curvature	cagA+/vacA s1m1	cagA+/vacA s1m1¹	595	NA
	Antrum greater curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	595/200	595
	Body greater curvature	cagA+/vacA s1m1¹	cagA+/vacA s1m1	595/200	595

¹Concurrent infection with cagA-/vacA s1m1 isolate;

²Concurrent infection with cagA-/vacA s2m2 isolate. NA: Did not amplify.

Table 2 Effect of the antibiotic pressure on the virulence-associated genotypes of Helicobacter pylori isolates obtained from 10 Colombian patients with treatment failure

Genotype	Before treatment (n = 22)	After treatment (n = 22)	P vaule
cagA
Positive	2 (9.1)	17 (77.3)	0.000
Mixed	20 (90.9)	5 (22.7)
vacA
s1m1	17 (22.7)	21 (95.5)	0.125
s2m2	5 (77.3)	1 (4.5)

Citation: Bustamante-Rengifo JA, Matta AJ, Pazos AJ, Bravo LE. Effect of treatment failure on the CagA EPIYA motif in Helicobacter pylori strains from Colombian subjects. World J Gastroenterol 2017; 23(11): 1980-1989
URL: https://www.wjgnet.com/1007-9327/full/v23/i11/1980.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i11.1980