Copyright
©The Author(s) 2017.
World J Gastroenterol. Jan 7, 2017; 23(1): 48-59
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.48
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.48
Table 1 cagA genotype and clinical outcome of subjects
H. pylori infection status and cagA genotype | Gastritis | Peptic ulcer | GERD | Total |
H. pylori-infected | 95 | 12 | 3 | 110 |
Western cagA | 34 | 4 | 0 | 38 |
East Asian cagA | 61 | 8 | 3 | 72 |
H. pylori-uninfected | 98 | 3 | 6 | 107 |
Total | 193 | 15 | 9 | 217 |
Table 2 Subject Helicobacter pylori-infection status
H. pylori status and cagA genotype | H. pylori infection status | cagA genotype | ||
Infected | Uninfected | Western | East Asian | |
ROC analysis group | ||||
n | 110 | 107 | 38 | 72 |
Male | 63 (57%)1 | 46 (43%)1 | 17 (45%) | 46 (64%) |
Age (yr) | ||||
mean ± SD | 40.1 ± 12.9 | 38.5 ± 12.8 | 38.6 ± 10.8 | 41.0 ± 13.8 |
Range | 18-76 | 19-78 | 18-69 | 21-76 |
Gastritis subjects group | ||||
n | 34 | 61 | ||
Male | 19 (56%) | 38 (62%) | ||
Age (yr) | ||||
mean ± SD | 37.5 ± 8.5 | 39.3 ± 13.0 | ||
Range | 22-60 | 20-70 |
Table 3 Association between cagA genotype and the accuracy of CagA antibody ELISA
Group name | n | Western-type CagA ELISA | East Asian-type CagA ELISA | ||||||
cagA genotype | (cut off value: 6.25 U/mL) | (cut off value: 45.0 U/mL) | |||||||
Sens. | Sp. | AUC | 95%CI | Sens. | Sp. | AUC | 95%CI | ||
Western and East Asian | 110 | 62.7 | 97.2 | 0.87 | 0.82-0.92 | 70.9 | 93.5 | 0.91 | 0.86-0.95 |
Western | 38 | 84.2 | 97.2 | 0.92 | 0.83-0.99 | 65.8 | 93.5 | 0.91 | 0.86-0.96 |
East Asian | 72 | 51.41 | 97.2 | 0.85 | 0.79-0.91 | 73.61 | 93.5 | 0.90 | 0.85-0.95 |
- Citation: Matsuo Y, Kido Y, Akada J, Shiota S, Binh TT, Trang TTH, Dung HDQ, Tung PH, Tri TD, Thuan NPM, Tam LQ, Nam BC, Khien VV, Yamaoka Y. Novel CagA ELISA exhibits enhanced sensitivity of Helicobacter pylori CagA antibody. World J Gastroenterol 2017; 23(1): 48-59
- URL: https://www.wjgnet.com/1007-9327/full/v23/i1/48.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i1.48