Jia ZF, Wang LZ, Cao XY, Wang C, Cao DH, Wu X, You LL, Jin MS, Wang YP, Zhou BS, Jiang J. CD24 genetic variants contribute to overall survival in patients with gastric cancer. World J Gastroenterol 2016; 22(7): 2373-2382 [PMID: 26900300 DOI: 10.3748/wjg.v22.i7.2373]
Corresponding Author of This Article
Jing Jiang, MD, PhD, Division of Clinical Epidemiology, First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province, China. jiangjing19702000@jlu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Table 4 Distributions of genotypes according to clinical parameters in gastric cancer cases
P-534
P value
P170
P value
P1527
P value
C/C
C/A
A/A
C/C
C/T
T/T
TG/TG
TG/del
n
181
358
140
295
308
76
559
120
Age
60 (53-70)
61 (54-71)
61 (55-70)
0.715
61 (53-71)
61 (54-70)
63 (56-70)
0.658
61 (54-70)
60 (51-71)
0.307
Sex
Male
27.3
50.3
22.4
0.092
43.9
44.2
11.9
0.485
83.6
16.4
0.172
Female
25.0
58.9
16.1
42.2
48.4
9.4
79.2
20.8
H. pylori
Positive
26.3
53.4
20.3
0.905
42.6
46.1
11.3
0.769
82.3
17.7
0.996
Negative
27.0
51.6
21.4
45.6
43.7
10.7
82.3
17.7
Differentiation
Poor
24.7
55.8
19.5
0.070
43.5
47.4
9.2
0.055
81.5
18.5
0.500
Moderate to well
30.2
46.0
23.8
45.0
40.1
14.8
83.7
16.3
TNM stage
I-II
26.2
52.8
21.0
0.999
45.1
44.7
10.2
0.695
82.4
17.6
0.986
III-IV
26.3
52.6
21.1
42.7
45.2
12.1
82.4
17.6
Pathologic type
Tubular adenocarcinoma
26.4
52.3
21.3
0.754
45.0
43.9
11.2
0.173
82.8
17.2
0.751
Signet ring cell
26.0
60.0
14.0
34.0
60.0
6.0
80.0
20.0
Other
27.9
50.0
22.1
38.2
47.1
14.7
85.3
14.7
Distant metastasis
Positive
32.3
48.5
19.2
0.323
40.4
44.4
15.1
0.374
79.8
20.2
0.454
Negative
25.1
53.9
20.9
44.3
45.2
10.5
82.9
17.1
CD24 staining
60 (0-120)
60 (0-120)
100 (20-140)
0.215
60 (0-120)
60 (20-120)
40 (0-100)
0.482
60 (0-120)
60 (40-100)
0.922
Table 5 Results of multivariate Cox regression analysis
P value
HR
95%CI
P-534
C/C + C/A
-
1.00
-
A/A
0.0416
1.38
1.01-1.88
Age
0.1875
1.01
1.00-1.02
Sex
Male
-
1.00
-
Female
0.2315
0.83
0.61-1.13
Differentiation
Moderate to well
-
1.00
-
Poor
0.0089
1.50
1.11-2.04
Pathologic type
Tubular adenocarcinoma
-
1.00
-
Signet ring cell
0.4750
0.83
0.50-1.39
Other
0.9469
1.01
0.67-1.53
TNM stage
I
-
1.00
-
II
0.0003
5.50
2.18-13.86
III
< 0.0001
22.29
9.05-54.89
IV
< 0.0001
32.12
12.63-81.70
Chemotherapy
No
-
1.00
-
FOLFOX-4
0.0195
0.64
0.45-0.93
XELOX
0.0021
0.43
0.25-0.74
Other
0.0004
0.45
0.29-0.70
Citation: Jia ZF, Wang LZ, Cao XY, Wang C, Cao DH, Wu X, You LL, Jin MS, Wang YP, Zhou BS, Jiang J. CD24 genetic variants contribute to overall survival in patients with gastric cancer. World J Gastroenterol 2016; 22(7): 2373-2382