Recurrent colorectal cancer after endoscopic resection when additional surgery was recommended

Table 1 Characteristics of patients and primary tumors

	Age			BMI		Pathological data
Case	(yr)	Sex	ASA	(kg/m2)	Location	Invasion depth	Differentiation	ly	v	VM	Budding
1	39	F	1	19.7	Rectum	sm (≥ 1000 μm)	Well	+	+	-	Grade 2
2	43	M	1	19.4	Rectum	sm (≥ 1000 μm)	Well	+	+	+	Unknown
3	71	F	1	17.0	Rectum	sm (< 1000 μm)	Well	+	+	-	Unknown
4	75	M	1	25.3	Transverse	sm (= 1000 μm)	Well	-	-	-	Grade 0
5	76	M	2	21.7	Rectum	un clear	Moderate	-	-	+	Grade 0
6	42	M	1	18.8	Rectum	sm (≥ 1000 μm)	Well	+	+	-	Grade 0
7	74	M	2	25.4	Rectum	sm (≥ 1000 μm)	Moderate	-	+	-	Grade 3
8	49	M	2	22.4	Sigmoid	sm (≥ 1000 μm)	Moderate	+	-	-	Grade 1

Table 2 Follow up and recurrence after endoscopic resection

	Use of adjuvant therapy
Case	After ESD	Follow up interval	Recurrence pattern	Time to recurrence
1	-	3 mo	Distant metastasis (lung, PALN)	8 mo
2	-	Every year	Local + regional lymphnode	10 mo
3	-	No follow	Distant metastasis (lung, liver)	7 yr
4	-	8 mo	Local	4 yr
5	-	No follow	Local + regional lymphnode	18 mo
6	XELOX 6 mo	No follow	Local	2 yr
7	-	Every year	Local + regional lymphnode	4 yr
8	-	No follow	Peritoneal dissemination	4 yr

Local: Intra mural; PALN: Para aortic lymphnode.

Table 3 Surgical outcomes

Case	Surgical procedures	Operating time	Estimated blood loss	Harvested	Lymphadenectomy	Complication
		(min)	(mL)	lymph nodes
1	Staging laparoscopy	139	10	-	-	-
2	Laparoscopic LAR	205	10	15	D3	Enteritis
3	Laparoscopic Sigmoid colostomy	-	-	-	-	-
4	Laparoscopic TCR	339	135	12	D2	-
5	Laparoscopic LAR	440	285	10	D3	Enteritis
6	Laparoscopic APR	403	200	18	D3	-
7	Laparoscopic LAR	227	20	13	D3	-
8	Laparoscopic SCR+	230	350	-	-	-
	Excision of peritoneal dissemination

LAR: Low anterior resection; TCR: Transverse colon resection; APR: Abdominoperineal resection; SCR: Sigmoid colon resection.

Table 4 Postoperative outcomes

Case	Pathological data									Survival outcome		Last follow-up
	Invasion depth	ly	v	ew	ow	aw	Lymphnode metastasis, n	Surgical margins	Therapy after surgery	Recurrence	(alive/death)	(mo)
1								R2	Systemic chemotherapy		Death	25
2	a	2	0	-	-	-	2	R0	Follow-up	-	Alive	106
3								R2	Systemic chemotherapy		Death	12
4	sm (700 μm)	0	0	-	-	-	0	R0	Follow-up	-	Alive	24
5	a	1	1	+	-	-	1	R1	Adjuvant chemotherapy	-	Alive	3
6	a	1	1	-	-	-	0	R0	Follow-up	-	Alive	7
7	a	0	1	-	-	-	1	R0	Adjuvant chemotherapy	-	Alive	23
8	Adenocarcinoma (recurrence of sigmoid colon cancer)							R0	Follow-up	-	Alive	33