Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease

Table 1 Histopathological scores of colitis

Group	n	0 d	7 d	14 d	21 d	28 d
Experiment	25	0.33 ± 0.21a	3.55 ± 1.05ac	3.32 ± 1.08ac	2.49 ± 0.68ac	1.12 ± 0.82ac
Model	25	0.21 ± 0.53a	3.67 ± 1.02a	4.56 ± 0.92a	4.98 ± 0.62a	5.67 ± 0.87a
Control	25	0.32 ± 0.15	0.28 ± 0.01	0.31 ± 0.05	0.28 ± 0.04	0.26 ± 0.07

^aP < 0.05 vs control group;

^cP < 0.05 vs model group. The results are shown as mean ± SD.

Table 2 Serum levels of interleukin-10, transforming growth factor-β1 and interleukin-17A

Group	n	IL-10 (pg/mL)	TGF-β1 (pg/mL)	IL-17a (pg/mL)
Experiment	5	98.79 ± 3.45ac	59.23 ± 2.01ac	67.82 ± 3.25ac
Model	5	34.56 ± 5.78	23.45 ± 3.68	14.35 ± 2.46
Control	5	143.35 ± 2.35	68.56 ± 3.59	76.28 ± 3.56

^aP < 0.05 vs model group;

^cP < 0.05 vs control group. The results are shown as mean ± SD. IL: Interleukin; TGF: Transforming growth factor.