Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features

Table 1 Clinical characteristics of previously reported cases

Author (yr)	Number of patients	Sex (M:F)	Age (yr, average)	Race or nationality	Clinical symptoms	Therapeutic method	Survival time (mo, average)	Outcome
Tsukamoto et al[4] (2007)	1	F	82	Japanese	No symptom	EMR	ND	ND
Ueyama et al[5] (2010)	10	6:4	65.5 (42-79)	Japanese: 10	ND	EMR: 2	37.1 (10-70)	Alive, NED: 10
						ESD: 5
						Operation: 3
Fukatsu et al[6] (2011)	1	M	56	Japanese	No symptom	EAM	12	Alive, NED
Terada et al[7] (2011)	1	M	78	Japanese	Abdominal pain (colon cancer)	No therapy (only biopsy)	3	Died (colon cancer)
Park et al[8] (2012)	3	3:0	65.3 (47-76)	Korean: 3	ND	ESD: 1	24.3 (11-32)	Alive, NED: 3
						Operation: 1
						Operation after ESD: 1
Singhi et al[9] (2012)	10	4:6	64.2 (44-79)	Hispanic: 4	GERD: 10	polypectomy: 10	15.4 (6-39)	Alive, NED: 8
				Caucasian: 2				Alive, persistence: 1 ND: 1
				African American: 2
				Chinese: 1
				Unknown: 1
Chen et al[10] (2012)	1	M	79	Caucasian	GERD	EMR	2	Alive, NED
					Esophageal stricture
Abe et al[11] (2013)	1	F	71	Japanese	No symptom	EMR	12	Alive, NED
Ueyama et al[12] (2014)	10	6:4	66.5 (55-78)	Japanese: 10	ND	EMR: 2	13.2 (1-19)	Alive, NED: 10
						ESD: 8
Miyazawa et al[13] (2015)	5	3:2	72.2 (67-78)	Japanese: 5	No symptom: 5	ESD: 4	19.4 (10-28)	Alive, NED: 5
						Operation after ESD: 1
Parikh et al[14] (2015)	1	M	66	Caucasian	Heartburn (GERD)	EMR	ND	Alive, NED
Kato et al[15] (2015)	1	M	80s	Japanese	ND	CLEAN-NET	3	Alive, NED
Fujii et al[16] (2015)	1	F	64	Japanese	ND	ESD	ND	ND

CLEAN-NET: Combination of laparoscopic and endoscopic approaches to neoplasia with non-exposure technique; EAM: Endoscopic aspiration mucosectomy; EMR: Endoscopic mucosal resection; ESD: Endoscopic submucosal dissection; F: Female; M: Male; GERD: Gastroesophageal reflux disease; NED: No evidence of disease; ND: Not described.

Table 2 Endoscopic characteristics of previously reported cases

Author (yr)	Number of patients	Location (U:M:L)	Size (mm, average)	Macroscopic shape	Color tone	Vessel findings	NBI with magnification
							MSP	MVP
Tsukamoto et al[4] (2007)	1	U	16	Elevated	Normal	Vasodilation	ND	ND
Ueyama et al[5] (2010)	10	10:0:0	8.6 (4-20)	Elevated: 5	ND	ND	ND	ND
				Depressed: 5
Fukatsu et al[6] (2011)	1	U	5	Elevated	Yellowish	ND	ND	ND
Terada et al[7] (2011)	1	U	20	Elevated	Reddish	Vasodilation	ND	ND
Park et al[8] (2012)	3	1:1:1	2.6 (1.2-3.6)	Elevated and depressed: 3	ND	ND	ND	ND
Singhi et al[9] (2012)	10	10:0:0	4.3 (2-8)	Elevated: 10	ND	ND	ND	ND
Chen et al[10] (2012)	1	U	12	Elevated	Whitish	Vasodilation	ND	ND
Abe et al[11] (2013)	1	U	ND	Elevated	Yellowish	ND	ND	ND
Ueyama et al[12] (2014)	10	6:4:0	9.3 (3-31)	Elevated: 6	Whitish: 8	Vasodilation: 5	ND	ND
				Depressed: 3	Reddish: 2	Normal: 5
Miyazawa et al[13] (2015)	5	5:0:0	7.8 (5-13)	Elevated: 4	Whitish: 3	Vasodilation: 5	Regular: 3	Regular: 3
				Flat: 1	Normal: 2		Absent: 2	Irregular: 2
Parikh et al[14] (2015)	1	U	7	Elevated	Reddish	Vasodilation	ND	ND
Kato et al[15] (2015)	1	U	15	Elevated	Whitish	Vasodilation	Regular	Regular
Fujii et al[16] (2015)	1	U	< 10	Depressed	Whitish	Vasodilation	Absent	Irregular

U: Upper third; M: Middle third; L: Lower third; NBI: Narrow-band imaging; MSP: Microsurface pattern; MVP: Microvascular pattern; ND: Not described.

Table 3 Histopathological characteristics of previously reported cases

Author (year)	Number of patients	Background mucosa	Depth (M:SM) (µm, average)	Lymphatic invasion (+:-)	Venous invasion (+:-)	MUC2 (+:-)	MUC5AC (+:-)	MUC6 (+:-)	CD10 (+:-)	Overexpression of p53 (+:-)	Ki-67 LI (%, average)
Tsukamoto et al[4] (2007)	1	ND	M	(-)	(-)	ND	ND	(+)	ND	ND	7.9
Ueyama et al[5] (2010)	10	Normal: 7	1:9	0:10	0:10	0:10	1:9	10:0	0:10	0:10	3.6
		Metaplasia: 1	844 (150 to 4000)
		ND: 2
Fukatsu et al[6] (2011)	1	ND	SM, 100	(-)	(-)	ND	(-)	(+)	ND	ND	ND
Park et al[8] (2012)	3	Metaplasia: 2	1:2	0:3	0:3	0:3	3:0	3:0	0:3	ND	ND
		Gastritis: 1
Singhi et al[9] (2012)	10	Normal: 7	10:0	0:10	0:10	0:3	0:10	10:0	ND	0:9	2.6
		Gastritis: 3								ND: 1	(0.2-10)
Chen et al[10] (2012)	1	Normal	SM (Details unknown)	(-)	(-)	(-)	(-)	(-)	(-)	(-)	3.8
Abe et al[11] (2013)	1	Normal	SM (Details unknown)	(-)	(-)	(-)	(-)	(-)	(-)	(-)	1.9
Ueyama et al[12] (2014)	10	Normal: 9	5:5	1:9	0:10	0:10	4:6	10:0	2:8	0:10	8.6 (1-20)
		Gastritis: 1	360 (100 to 1200)
Miyazawa et al[13] (2015)	5	Normal: 4	0:5	1:4	0:5	0:5	0:5	5:0	ND	0:5	Very low: 5 (Details unknown)
		Gastritis: 1	620 (80 to 1230)
Parikh et al[14] (2015)	1	ND	SM (Details unknown)	(-)	(-)	ND	ND	ND	ND	ND	ND
Kato et al[15] (2015)	1	Normal	SM, 300	(-)	(-)	ND	ND	(+)	ND	ND	ND
Fujii et al[16] (2015)	1	Normal	SM, 300	(-)	(-)	ND	(-)	(+)	ND	ND	ND

LI: Labeling index; M: Mucosal; SM: Submucosal; ND: Not described.