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©The Author(s) 2016.
World J Gastroenterol. Dec 21, 2016; 22(47): 10406-10414
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10406
Published online Dec 21, 2016. doi: 10.3748/wjg.v22.i47.10406
Table 1 Patient, tumor, and treatment characteristics patients treated (n = 34)
n (%) | ||
FDG avidity | Yes | 19 (56) |
No | 15 (44) | |
ECOG-PS1 | 0 | 17 (50) |
1 | 14 (41) | |
≥ 2 | 3 (9) | |
Gender | Female | 9 (27) |
Male | 25 (74) | |
Grade | G1 | 18 (53) |
G2 | 6 (18) | |
G3 | 1 (3) | |
Unknown | 9 (27) | |
Presence of cirrhosis | 20 (59) | |
Causes of cirrhosis (n = 20) | Viral hepatitis | 12 (60) |
Hepatitis B | 2 (10) | |
Hepatitis C | 10 (50) | |
Alcohol | 4 (20) | |
NASH2 | 4 (20) | |
Prior treatment | 15 (44) | |
Child pugh class | A | 31 (91) |
B | 3 (9) | |
BCLC stage3 | A | 4 (12) |
B | 10 (29) | |
C | 19 (56) | |
D | 1 (3) | |
Tumor burden4 | ≤ 50% | 29 (85) |
> 50% | 5 (15) | |
Portal vein thrombosis | 5 (15) | |
Extrahepatic disease | 3 (9) | |
Median (Range) | ||
Age | 68 (46-84) | |
PET SUVmax | 4 (2-20) | |
Initial AFP | 14 (1-186000) | |
Volume treated (mL) | 1146 (191-2340) | |
Dose delivered (Gy) | 126.6 (110.5-478.6) | |
Follow up (mo) | 12 (1-63) |
Table 2 Predictive factors associated with FDG avidity
Non-avid patients | PET-avid patients | UVA | ||
n (%) | n (%) | P value | ||
ECOG-PS1 | 0 | 9 (60) | 8 (40) | 0.58 |
1 | 5 (33) | 9 (47) | ||
≥ 2 | 1 (7) | 2 (11) | ||
Gender | Female | 1 (7) | 8 (42) | 0.0474 |
Male | 14 (93) | 11 (58) | ||
Pathology-differentiation | Well | 10 (67) | 8 (42) | 0.311 |
Moderate | 1 (7) | 5 (26) | ||
Poor | 0 (0) | 1 (5) | ||
Unknown | 4 (27) | 5 (26) | ||
BCLC stage2 | A | 3 (20) | 1 (5) | 0.123 |
B | 6 (40) | 4 (21) | ||
C+ | 6 (40) | 14 (74) | ||
Tumor burden | ≤ 50% | 14 (93) | 15 (79) | 0.3554 |
> 50% | 1 (7) | 4 (21) | ||
Portal vein thrombosis | No | 14 (93) | 15 (79) | 0.24 |
Yes | 5 (33) | 10 (53) | ||
Extrahepatic disease | No | 14 (93) | 17 (90) | 1.004 |
Yes | 1 (7) | 2 (11) | ||
Prior treatment | No | 9 (60) | 10 (53) | 0.67 |
Yes | 6 (40) | 9 (47) | ||
Child-Pugh-class | A | 14 (93) | 17 (90) | 1.004 |
B | 1 (7) | 2 (11) | ||
Viral hepatitis | No | 8 (53) | 14 (74) | 0.22 |
Yes | 7 (47) | 5 (26) | ||
Cirrhosis | No | 14 (93) | 16 (84) | 0.41 |
Yes | 10 (67) | 10 (53) | ||
Median (Range) | Median (Range) | |||
Age | 59 (46-84) | 71 (57-84) | 0.10 | |
PET SUV3 | 2(2-2) | 6(3-20) | - | |
Initial AFP | 12 (1-478) | 16 (2-186000) | 0.23 | |
Volume treated (mL) | 1260 (400-2044) | 1091 (191-2340) | 0.39 | |
Dose delivered (Gy) | 125.9 (111.1-478.6) | 128.5 (110.5-467.5) | 0.66 |
Table 3 Univariate and multivariate analysis
Variables1 | LLC (n = 38) | DLC (n = 34) | DM (n = 31) | PFS (n = 34) | OS (n = 34) | ||||||||||
UVA (P) | MVA (P) | HR (95%CI) | UVA (P) | MVA (P) | HR (95%CI) | UVA (P) | MVA (P) | HR (95%CI) | UVA (P) | MVA (P) | HR (95%CI) | UVA (P) | MVA (P) | HR (95%CI) | |
FDG Avidity (avid vs non-avid) | 0.003 | 0.002 | 6.3 (2.0-20.4) | 0.003 | 0.015 | 57.7 (2.2-1496.9) | < 0.001 | NS | 0.015 | 0.008 | 4.04 (1.4-11.3) | 0.893 | - | ||
ECOG (0 vs 1 vs≥ 2) | 0.120 | - | 0.038 | NS | 0.990 | - | 0.049 | NS | 0.002 | NS | |||||
Gender (female vs male) | 0.100 | NS | 0.398 | - | 0.596 | - | 0.100 | NS | 0.122 | - | |||||
Pathology (grade 1 vs 2 vs 3 vs unknown) | 0.059 | NS | 0.034 | NS | 0.048 | NS | 0.016 | NS | 0.688 | - | |||||
Extrahepatic disease | < 0.001 | < 0.001 | 38.9 (6.6-229.2) | < 0.001 | NS | - | - | < 0.001 | < 0.001 | 47 (7.7-286) | < 0.001 | NS | |||
Tumor Burden ( ≤ 50% vs > 50%) | < 0.001 | NS | 0.009 | NS | 0.990 | - | 0.012 | NS | 0.004 | NS | |||||
Cirrhosis | 0.477 | - | 0.588 | - | 0.732 | - | 0.593 | - | 0.065 | NS | |||||
Age (yr) | 0.405 | - | 0.405 | - | 0.238 | - | 0.232 | - | 0.100 | NS |
- Citation: Abuodeh Y, Naghavi AO, Ahmed KA, Venkat PS, Kim Y, Kis B, Choi J, Biebel B, Sweeney J, Anaya DA, Kim R, Malafa M, Frakes JM, Hoffe SE, El-Haddad G. Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization. World J Gastroenterol 2016; 22(47): 10406-10414
- URL: https://www.wjgnet.com/1007-9327/full/v22/i47/10406.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i47.10406