Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes

Table 1 Comparison of features of portal hypertension between the groups requiring single liver transplant and those requiring combined liver/kidney transplant (note some patients had > 1 manifestation)

	Single organ liver (n = 15 with portal HBP)	Combined liver/kidney (n = 4 with portal HBP)	P value
Ascites	8	3	0.582
Varices1	1	0	0.745
Splenomegaly2	7	2	0.585
Thrombocytopenia3	3	2	0.379

¹Confirmed endoscopically or radiologically on CT;

²Confirmed on imaging without evidence of splenic cysts;

³Platelet count < 150 × 10⁹. HBP: Hypertension.

Table 2 Comparison of patient demographics between patients with and without portal hypertension

Listing parameter	Portal hypertension (n = 19)	Non-portal hypertension (n = 28)	P value
Age (yr)	50.6 (6.4)	47.1 (7.4)	0.101
Female gender	17 (89.5)	25 (89.3)	0.683
Bilirubin (μmol/L)	8 (6-11)	8 (6-12)	0.965
INR	1.1 (1.0-1.2)	1.1 (1.0-1.1)	0.173
Creatinine (mmol/L)	106 (104-436)	119 (92-201)	0.508
Platelet count (× 109)	177 (147-242)	234 (198-242)	0.012
Sodium (mmol/l)	139 (137-143)	140 (138-142)	0.483
MELD score	12 (9-21)	11 (8-16)	0.422
UKELD score	48 (44-50)	46 (45-48)	0.344
Chronic kidney disease1	16 (84.2)	19 (67.9)	0.179
Dialysis dependant	3 (15.8)	2 (7.1)	0.317

¹Chronic kidney disease defined as stage III-V[17]. INR: International normalized ratio; MELD: Model For End-stage Liver Disease; UKELD: United Kingdom Model for End-Stage Liver Disease.

Table 3 Intensive care unit requirements and hospital stay between the portal hypertensive and non-portal hypertensive groups in patients receiving a single organ liver transplant

	Portal hypertensive group (n = 8)	Non-portal hypertensive group (n = 14)	P value
Intra-operative
RCC(units)	3 (1-4)	4 (2-7)	0.238
FFP(units)	10 (1-18)	8 (7-14)	0.973
Plts (units)	0	3 (0-10)	0.145
ICU stay (d)	3 (3-4)	2 (2-4)	0.188
Hospital stay (d)	9 (7-13)	10 (7-12)	0.973
RRT in ICU immediately post-op	2/8 (25%)	0/14 (0)	0.121

FFP: Fresh frozen plasma; ICU: Intensive care unit; Plts: Platelets; RCC: Red cell concentrate; RRT: Renal replacement therapy.

Table 4 Intensive care unit requirements and hospital stay between the portal hypertensive and non-portal hypertensive groups in patients receiving a combined liver/kidney transplant

	Portal hypertensive group (n = 4)	Non-portal hypertensive group (n = 8)	P value
Intra-operative
RCC (units)	13 (4-19)	9 (3-19)	0.933
FFP (units)	15 (7-23)	14 (5-18)	0.683
Plts (units)	10 (3-10)	10 (0-20)	0.683
ICU stay (d)	5 (3-7)	7 (3-41)	0.368
Hospital stay (d)	16 (12-18)	15 (12-49)	0.808
RRT in ICU immediately post-op	3/4 (75%)	3/8 (37.5%)	0.273

FFP: Fresh frozen plasma; ICU: Intensive care unit; Plts: Platelets; RCC: Red cell concentrate; RRT: Renal replacement therapy.